Nε boc l lysine methyl ester hydrochloride h lys boc ome hcl

Oxaliplatin (OP) was purchased from Jiangsu Hengrui Medicine Co., Ltd. (Jiangsu Province, China). Caprylocaproyl macrogol-8-glycerides (Labrasol) were obtained from Gattefossé (Saint Priest, France). Polyoxyethylene (160) polyoxypropylene (30) glycol (poloxamer 188, P188) was provided by BASF (Ludwigshafen, Germany). DC, ethyl chloroformate, N-methylmorpholine, N^ε-Boc-l-lysine methyl ester hydrochloride (H-Lys(Boc)-OMe·HCl), lithium aluminum hydride (LiAlH₄), trimethylsilyl diazomethane (2 M solution in hexane), ammonium acetate, and formic acid were purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). Solvents for high-performance liquid chromatography (HPLC) and inductively coupled plasma-mass spectroscopy (ICP-MS) analyses were obtained from Merck and Thermo Fisher Scientific (Waltham, MA, USA).

Recombinant human PTH (1-34) (teriparatide, rhPTH [1-34]) was prepared by GL Biochem (Shanghai, People’s Republic of China). N-Methylmorpholine, deoxycholic acid (DOCA), ethyl chloroformate, N^ε-Boc-l-lysine methyl ester hydrochloride (H-Lys(Boc)-OMe·HCl), and 2,2,2-trifluoroethanol (TFE) were from Sigma-Aldrich Co. (St Louis, MO, USA). Poly(methacylic acid-co-ethyl acrylate) (Eudragit L100-55) was obtained as a sample from Evonik Nutrition & Care GmbH (Essen, Germany). Tetrahydrofuran, chloroform, acetyl chloride, methanol, and n-hexane (analytical grade) were purchased from EMD Millipore/Merck (Billerica, MA, USA). High-performance liquid chromatography (HPLC)-grade solvents were obtained from Thermo Fisher Scientific (Waltham, MA, USA) and EMD Millipore.