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Inveon trimodality pet spect ct scanner

Manufactured by Siemens
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The Inveon trimodality PET/SPECT/CT scanner is a versatile imaging platform that combines positron emission tomography (PET), single-photon emission computed tomography (SPECT), and computed tomography (CT) capabilities in a single system. The scanner enables the acquisition of multimodal data, allowing for comprehensive evaluation of biological processes and anatomical structures in preclinical research applications.

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3 protocols using inveon trimodality pet spect ct scanner

1

High-Resolution Imaging of Lung Structures

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Embryos were fixed in 4% PFA in PBS overnight. Lungs were removed, pre-treated with 25% Lugol’s solution for 1 hour, and then soaked in PBS for 1 hour prior to imaging. CT images consisting of 360 degrees and 600 projections were acquired by using an Inveon trimodality PET/SPECT/CT scanner (Siemens Preclinical Solutions, Knoxville, TN). The exposure time was 2.9 seconds with detector settings at 80 kVp and 150 µA. Data was reconstructed onto a 1792×1792×2688 image matrix using the COBRA software package (Exxim Computing Corporation, Pleasanton, CA). The effective image voxel size was 33.6 µm isotropic. Reconstructed images were analyzed using Osirix software.
Merrell A.J., Ellis B.J., Fox Z.D., Lawson J.A., Weiss J.A, & Kardon G. (2015). Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias. Nature genetics, 47(5), 496-504.
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2

High-Resolution Imaging of Lung Structures

Check if the same lab product or an alternative is used in the 5 most similar protocols
Embryos were fixed in 4% PFA in PBS overnight. Lungs were removed, pre-treated with 25% Lugol’s solution for 1 hour, and then soaked in PBS for 1 hour prior to imaging. CT images consisting of 360 degrees and 600 projections were acquired by using an Inveon trimodality PET/SPECT/CT scanner (Siemens Preclinical Solutions, Knoxville, TN). The exposure time was 2.9 seconds with detector settings at 80 kVp and 150 µA. Data was reconstructed onto a 1792×1792×2688 image matrix using the COBRA software package (Exxim Computing Corporation, Pleasanton, CA). The effective image voxel size was 33.6 µm isotropic. Reconstructed images were analyzed using Osirix software.
Merrell A.J., Ellis B.J., Fox Z.D., Lawson J.A., Weiss J.A, & Kardon G. (2015). Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias. Nature genetics, 47(5), 496-504.
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3

Multimodal Imaging for Embryo Analysis

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Images were acquired using an Inveon trimodality PET/SPECT/CT scanner (Siemens Preclinical Solutions, Knoxville, TN). CT images consisting of 360 degrees and 720 projections were acquired first with the axial field of view of 60.28 mm and transaxial field of view of 30.89 mm. The large field of view allowed two specimens to be scanned at a time. The exposure time was 2,200 msec with a detector setting at 80 kVp and 150 µA. Data were reconstructed onto a 1312 × 1312 × 2560 image matrix using the Siemens Inveon FeldKamp software package. The effective image pixel size was 23.55 µm. Crown-rump length, skull length, cranial height and bi-parietal diameter were obtained.
Julander J.G., Siddharthan V., Park A.H., Preston E., Mathur P., Bertolio M., Wang H., Zukor K., Van Wettere A.J., Sinex D.G, & Morrey J.D. (2018). Consequences of in utero exposure to Zika virus in offspring of AG129 mice. Scientific Reports, 8, 9384.
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