Male sprague dawley rat
Manufactured by Charles River Laboratories
Sourced in United States, China, Germany, Japan, Canada, United Kingdom, France, Italy, Morocco, Sweden
Male Sprague-Dawley rats are a widely used laboratory animal model. They are characterized by their large size, docile temperament, and well-established physiological and behavioral characteristics. These rats are commonly used in a variety of research applications.
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1 198 protocols using male sprague dawley rat
1
Sprague-Dawley Rat Behavioral Tests
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— Male Sprague-Dawley rats (7 weeks; Charles River, Yokohama, Kanagawa, Japan) were used for behavioral tests except for a corticosterone (CORT) treatment model in which Male Sprague-Dawley rats (4 weeks old at the beginning of the experiments; Charles River, Yokohama, Japan) were used. The animals were maintained under controlled temperature (23°C ± 3°C) and humidity (50% ± 20%) conditions under a 12-hour-light/-dark cycle (lights on at 7:00 am ). Food and water were provided ad libitum. All the studies were performed according to the guidelines of the Taisho Pharmaceutical Co., Ltd. Animal Care Committee and met the Japanese Experimental Animal Research Association standards, as defined in the Guidelines for Animal Experiments. TP0473292, TP0178894, and 1-O-(tricyclo[3.3.1.13,7]decane-1-carbonyl)-β-D-glucopyranuronic acid (TP0478768) were synthesized at the Research Center of Taisho Pharmaceutical Co., Ltd. Adamantane-1-carboxylic acid (TP0037870) and LY379268 were purchased from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan) and Abcam plc. (Cambridge, UK), respectively. For in vivo studies, TP0473292 was suspended in 0.5% methyl cellulose 400, and LY379268 was dissolved with 0.3% Tween 80.
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2
Behavioral and Microdialysis Studies in Rats
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For the behavioral experiments, male Sprague-Dawley rats (Charles River) weighing 300–325 g at the beginning of the study were individually housed and maintained in temperature- and humidity-controlled facilities fully accredited by AAALAC. Animals were housed on a 12 h/12 h dark/light cycle (lights out from 8:00 am to 8:00 pm). Behavioral experiments were conducted in the dark phase. For the microdialysis experiments, male Sprague-Dawley rats (Charles River) weighing 200–275 g at the beginning of the study were housed two to a cage and maintained in temperature- and humidity-controlled facilities fully accredited by AAALAC. Animals were housed on a 12 h/12 h light/dark cycle (lights out from 8:00 pm to 8:00 am). Microdialysis experiments were conducted in the light phase. All experimental procedures were approved and conducted in accordance with guidelines of the Institutional Animal Care and Use Committee of the Intramural Research Program National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services and the University of Maryland, Baltimore. All treatment groups were randomly assigned for each study. Only animals meeting the specified criteria per experiment were analyzed.
3
Rodent Housing and Enrichment Protocols
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The experimental procedures performed in this study were approved by the Laurentian University Animal Care Committee. Male Sprague-Dawley rats (n = 106, 434±60 gms) were obtained from Charles River Laboratories (Senneville, QC) and were housed and fed a 22/5 rodent diet (Envigo, WI, USA) according to Standard Operating Procedures and Policies for the Housing and Environmental Enrichment of Rodents at the Laurentian University Animal Care Facility. Experiments began following a one-week acclimation period.
All of the experiments and procedures in this study were approved by the Laurentian University Animal Care Committee. Male Sprague-Dawley rats (n = 106, 434±60 gms) were obtained from Charles River Laboratories (Senneville, QC) and were housed and fed a 22/5 rodent diet (Envigo, WI, USA) according to Standard Operating Procedures and Policies for the Housing and Environmental Enrichment of Rodents at the Laurentian University Animal Care Facility.
All of the experiments and procedures in this study were approved by the Laurentian University Animal Care Committee. Male Sprague-Dawley rats (n = 106, 434±60 gms) were obtained from Charles River Laboratories (Senneville, QC) and were housed and fed a 22/5 rodent diet (Envigo, WI, USA) according to Standard Operating Procedures and Policies for the Housing and Environmental Enrichment of Rodents at the Laurentian University Animal Care Facility.
4
In Vivo and Ex Vivo Studies of Rodents and Primates
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For mouse in vivo RO studies, male C57Bl/6 mice (25-30 g; Charles River, Raleigh, NC) were used. All procedures were approved by the Institutional Animal Care and Use Committee in accordance with The Guide for the Care and Use of Laboratory Animals.
For mouse ex vivo occupancy and ex vivo K i studies, male CD1 mice (approximately 30 g; Charles River, Margate, Kent) were used. All experiments were performed in accordance with UK Home Office regulations and in line with the Animals Scientific Procedures Act For rat ex vivo RO studies, male Sprague-Dawley rats (250-300 g; Charles River) were used. For rat PET imaging, male Sprague-Dawley rats (350-450 g; Charles River) were used. Both experiments were performed in accordance with UK Home Office regulation and in line with the Animals Scientific Procedures Act and transposed EU Directive 2016/63/EU.
Cynomolgus monkey PET imaging was performed on two adult cynomolgus monkeys (Macaca fascicularis), one female (8 years old) and one male (16 years old). This study was conducted in full compliance with Yale University's Institutional Animal Care and Use Committee policies and procedures, which follow the recommendations of The Guide for the Care and Use of Laboratory Animals.
For mouse ex vivo occupancy and ex vivo K i studies, male CD1 mice (approximately 30 g; Charles River, Margate, Kent) were used. All experiments were performed in accordance with UK Home Office regulations and in line with the Animals Scientific Procedures Act For rat ex vivo RO studies, male Sprague-Dawley rats (250-300 g; Charles River) were used. For rat PET imaging, male Sprague-Dawley rats (350-450 g; Charles River) were used. Both experiments were performed in accordance with UK Home Office regulation and in line with the Animals Scientific Procedures Act and transposed EU Directive 2016/63/EU.
Cynomolgus monkey PET imaging was performed on two adult cynomolgus monkeys (Macaca fascicularis), one female (8 years old) and one male (16 years old). This study was conducted in full compliance with Yale University's Institutional Animal Care and Use Committee policies and procedures, which follow the recommendations of The Guide for the Care and Use of Laboratory Animals.
5
Nanoparticle Toxicity Evaluation in Rats
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Male Sprague–Dawley (SD) rats were purchased from Charles River Laboratory (Raleigh, NC, USA) at 51–54 days of age and weighed between 201–225 g. Rats were housed two per cage under a 12 h light/dark cycle. Standard rat chow and water were provided ad libidum. Animals were randomly assigned to the following experimental groups for 1 day or 7 days post-instillation analysis: Naïve, Citrate Vehicle, 20 nm Au-AgNp/Citrate, 100 nm Au-AgNP/Citrate, polyvinylprryolidone (PVP) Vehicle, 20 Au-AgNP/PVP, and 110 nm Au-AgNP/PVP. Animals were allowed a 1 week acclimatization period in the East Carolina University Department of Comparative Medicine vivarium before beginning experimentation. East Carolina University’s Institutional Animal Care and Use Committee approved all animal handling and experimental procedures.
6
Sprague Dawley Rat Biochemical Assay
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Male Sprague Dawley (SD) rats were obtained from Charles River. Culture media and additives were obtained from Invitrogen. All chemicals were obtained from Sigma unless otherwise stated. BAY60-6583 was from Tocris. Antibodies to YAP, phospho-YAPS127, phospho-YAPS397, TAZ, pan-TEAD and phospho-Retinoblastoma protein were from Cell Signalling Technologies. Anti-BrDU antibody was from Sigma.
7
Housing Sprague-Dawley and Zucker Rats
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Male Sprague-Dawley (SD) rats (Charles River Laboratories, St-Constant, QC, Canada), weighing 176 to 225 g, 6 to 8 weeks of age, and Zucker ZUC-Leprfa/fa rats (Charles River Laboratories, Raleigh, NC), weighing 180-200g, 6 weeks of age, were housed in the animal facility at the Hôpital Maisonneuve-Rosemont Research Center and were provided with Harlan Teklad rodent diet #2014 (Envigo, Lachine, QC, Canada) and water ad libitum.
8
Rat Bone Marrow Isolation and Unilateral Ureteral Obstruction
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We used male Sprague–Dawley (SD) rats (Charles River Laboratories Japan, Yokohama, Japan) and male CAG‐enhanced green fluorescent protein (EGFP)‐transgenic SD rats (Japan SLC, Shizuoka, Japan) at 6 weeks of age for collecting bone marrow. We used SD rats (8 weeks old) for inducing UUO. The animal studies were all conducted according to the “Guide for the Care and Use of Laboratory Animals, 8th ed., 2010” (National Institutes of Health, Bethesda, MD) and were approved by the Institutional Animal Care and Use Committee of Hiroshima University (Hiroshima, Japan; Permit Number: A13‐34).
9
Sprague–Dawley Rat Welfare Protocol
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Male Sprague–Dawley (SD) rats weighing 151–175 g from Charles River (Charles River Wiga GmbH, Sulzfeld) were used. The animals were treated according to the ethics criteria established by the National Academy of Sciences and published by the National Institutes of Health, in addition to the legal requirements of Germany. All animal experiments were approved by the local government (Regierung von Oberbayern, Munich) and were reported to the responsible authorities.
10
Rat Hepatic Index Study
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The present study was approved by the Italian Ministry of Health (Ministero della Salute) (certificate no. 649/2016-PR, 1 July 2016). Experiments were carried out in accordance with local and national guidelines for animal experimentation.
Male Sprague-Dawley (SD) rats aged 8 weeks, weighing 150–200 g, were purchased from the Charles River Laboratories Italia, SRL (Lecco, Italia). All animals were housed under standard laboratory conditions in an animal holding room located at the Department of Biological Sciences and Technologies (Di.S.Te.B.A.), University of Salento (certificate no.48/2004-A). The acclimatization period was not less than one week after delivery. They were fed with standard chow diet and water was provided ad libitum. They were housed in small groups in plastic-bottomed cages containing sawdust. They were bred in a temperature-controlled environment (20 ± 2 °C) with 12 h of light/dark cycles (light from 6:00 a.m. to 6:00 p.m.). At specific time points, they were deeply anesthetized using isoflurane (drop jar method by placing an impermeable mesh grid over the cotton/gauze) and sacrificed through rapid dislocation of the cervical spine.
Body weight, liver weight and Hepatic Index (HI) (percentage of liver weight with respect to body mass) were monitored.
Male Sprague-Dawley (SD) rats aged 8 weeks, weighing 150–200 g, were purchased from the Charles River Laboratories Italia, SRL (Lecco, Italia). All animals were housed under standard laboratory conditions in an animal holding room located at the Department of Biological Sciences and Technologies (Di.S.Te.B.A.), University of Salento (certificate no.48/2004-A). The acclimatization period was not less than one week after delivery. They were fed with standard chow diet and water was provided ad libitum. They were housed in small groups in plastic-bottomed cages containing sawdust. They were bred in a temperature-controlled environment (20 ± 2 °C) with 12 h of light/dark cycles (light from 6:00 a.m. to 6:00 p.m.). At specific time points, they were deeply anesthetized using isoflurane (drop jar method by placing an impermeable mesh grid over the cotton/gauze) and sacrificed through rapid dislocation of the cervical spine.
Body weight, liver weight and Hepatic Index (HI) (percentage of liver weight with respect to body mass) were monitored.
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