Details on SRS planning and delivery have been previously published.10 (link) In brief, patients were treated with single-fraction LINAC-based framed SRS and planned using either Brainscan or iPlan treatment-planning software (Brainlab, Feldkirchen, Germany). All patients underwent a high-resolution treatment-planning MRI scan with and without contrast before CT simulation. The treatment-planning MRI scan was registered to the CT simulation using Brainlab software. The gross target volume (GTV) was defined as the entire enhancing lesion or resection cavity, including any residual enhancing disease. The GTV was then expanded from 0 to 2 mm in all directions to create a planning target volume (PTV). Typical expansions were 1 mm to PTV for intact lesions and 1 mm clinical target volume (CTV) and 1 mm PTV expansion (for a total of 2 mm) for resection cavities. Prescribed dose varied according to lesion size and was consistent with the findings from Radiation Therapy Oncology Group (RTOG) protocol 90-05.11 (link) Targets up to 20 mm in diameter were typically dosed to 21 Gy, 21-30 mm to 18 Gy, and 31-40 mm to 15 Gy.
Brainscan
Manufactured by Brainlab
Sourced in Germany
Brainscan is a neurosurgical imaging system used for visualizing and mapping the brain during surgical procedures. It provides real-time, three-dimensional images of the patient's brain anatomy to assist surgeons in navigation and guidance during operations.
Automatically generated - may contain errors
3 protocols using brainscan
1
Single-Fraction SRS for Brain Lesions
2
Stereotactic Radiosurgery for Meningiomas
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From 1995 to 2003, meningioma patients underwent “sharp” fixation using a stereotactic head ring and an oral bite plate. A 6-MV Linac (Varian Medical Systems, USA) with an add-on micro multi-leaf collimator (BrainLAB, Germany) was used. Coordinates for SRS were set by a laser-based stereotactic localizer. This setup allowed delivering shaped beams. In 2004, the department started using NovalisTx with beam shaping capability using built-in MLC and image guidance with ExacTrac (Varian Medical Systems, USA and BrainLAB, Germany). The image-guided frameless system enabled us to image the patient at any couch position using a frameless positioning array. A three-dimensional treatment planning based on CT and co-registered MRI was done with Brainscan (BrainLAB, Germany), which was later replaced by iplanRT (BrainLAB, Germany). The GTV was defined as the area of contrast enhancement on T1-weighted MR images and the planning target volume (PTV) included a 1–2 mm isotropic safety margin. The dose was prescribed to a reference point, representing 100%. Patients received 95% of the prescribed dose at the PTV margin. Dose constraints for OAR were as follows: optic nerves, chiasma, and brainstem could receive maximal 54 Gy according to Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) [13 (link)].
3
Stereotactic Radiosurgery for Meningioma
Check if the same lab product or an alternative is used in the 5 most similar protocols
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From 1995 to 2003, meningioma patients underwent “sharp” fixation using a stereotactic head ring and an oral bite plate. A 6-MV linear accelerator (LINAC) (Varian Medical Systems, USA) with an add-on micro-multileaf collimator (BrainLAB, Germany) was used. Coordinates for SRS were set by a laser-based stereotactic localizer, which allowed the delivery of shaped beams. In 2004, the department started using Novalis Tx with beam shaping capability using built-in multileaf collimator (MLC) and image guidance with ExacTrac (Varian Medical Systems, USA, and BrainLAB, Germany). The image-guided frameless system enabled imaging with high accuracy independent of couch position. A three-dimensional treatment planning based on CT-co-registered with MRI was calculated using BrainScan (BrainLAB, Germany), which was later replaced by iPlan RT (BrainLAB, Germany). The gross tumor volume (GTV) was defined as the area of contrast enhancement on T1-weighted MR images, and the planning target volume (PTV) included a 1–2 mm isotropic safety margin. The dose was prescribed to a reference point, representing 100%. Patients received 95% of the prescribed dose at the PTV margin.
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