Eµ-TCL1 (TCL1) mice on C57BL/6 background were kindly provided by Dr. Carlo Croce (Ohio State University) [21 (link)]. Nr4a1GFP mice and Myd88−/− mice were a kind gift from Dr. Markus Feuerer (DKFZ, Heidelberg) [22 (link)] and Prof. Dr. Hermann-Josef Gröne (DKFZ, Heidelberg) [23 (link)], respectively. Adoptive transfer (AT) of TCL1 leukemia in C57BL/6N wild-type mice (Janvier Labs, Saint-Berthevin, France) was performed as described before [24 (link)].
C57bl 6n wild type mice
Manufactured by Janvier Labs
Sourced in France
C57BL/6N wild-type mice are a commonly used inbred mouse strain. They serve as a standard reference strain for various research applications.
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4 protocols using c57bl 6n wild type mice
1
Adoptive Transfer of TCL1 Leukemia
2
Conditional Knockout of CD44 in Mice
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All animal experiments were approved by the responsible authority for animal experiments (Regierungspräsidium Karlsruhe, Germany) and performed in conformity with the German Law for Animal Protection (animal license number: G-122/16, G-171/21).
CD44-/- (full name B6-Cd44tm1Mak) mice were kindly provided by Dr. Tak W. Mak (Department of Immunology, University of Toronto, Canada) and already described (24 (link)). C57Bl/6N wild-type mice were purchased from Janvier Labs. Ve-Cadherin CreERT2 mice were kindly provided by Prof. Ralf Adams (Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster), Csf1R-Cre (29 (link)) and GFAP-Cre (27 (link)) were provided by Prof. Michael Platten (Department of Neurology, University Heidelberg).
CD44fl/fl floxed mice were crossed with Csf1R-Cre to obtain Csf1R-Cre/CD44fl/fl mice and with GFAP-Cre mice to obtain GFAP-Cre/CD44fl/fl mice. Ve-Cadherin CreERT2 were crossed with CD44fl/fl floxed mice to obtain Ve-Cadherin CreERT2/CD44fl/fl mice. To induce recombination of floxed alleles, 4-week-old mice were treated with 1 mg/20g body weight Tamoxifen in peanut oil for five consecutive days. As a control, mice were treated with peanut oil.
CD44-/- (full name B6-Cd44tm1Mak) mice were kindly provided by Dr. Tak W. Mak (Department of Immunology, University of Toronto, Canada) and already described (24 (link)). C57Bl/6N wild-type mice were purchased from Janvier Labs. Ve-Cadherin CreERT2 mice were kindly provided by Prof. Ralf Adams (Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster), Csf1R-Cre (29 (link)) and GFAP-Cre (27 (link)) were provided by Prof. Michael Platten (Department of Neurology, University Heidelberg).
CD44fl/fl floxed mice were crossed with Csf1R-Cre to obtain Csf1R-Cre/CD44fl/fl mice and with GFAP-Cre mice to obtain GFAP-Cre/CD44fl/fl mice. Ve-Cadherin CreERT2 were crossed with CD44fl/fl floxed mice to obtain Ve-Cadherin CreERT2/CD44fl/fl mice. To induce recombination of floxed alleles, 4-week-old mice were treated with 1 mg/20g body weight Tamoxifen in peanut oil for five consecutive days. As a control, mice were treated with peanut oil.
3
Generation and Use of Knockout Mouse Models
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Bsep KO FVB/N mice were kindly provided as breeder pairs by the British Columbia Cancer Research Center[4 ]; multidrug resistance protein 2 (Mdr2) KO FVB/N mice were initially obtained from Jackson Laboratory (Bar Harbor, ME).[22 ] Details on the experimental procedures using LPS and the microtubule inhibitor colchicine are provided in the Supporting Information . Bile duct ligation (BDL) was performed in male C57BL6/N wild‐type (WT) mice (Janvier Labs, France) as described[23 ] (also see Supporting Materials and Methods ).
4
Mice Genotypes for Immunology Research
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C57BL/6N (wild-type, WT) mice were purchased from Janvier Labs. Stat1β/β (25 (link)), Stat2−/− (26 (link)), Irf9−/− (27 (link)), and Irf1−/− (28 (link)) were on C57BL/6 background. Stat1β/βStat2−/− and Stat1β/βIrf9−/− were generated by crossing Stat1β/β with Stat2−/− or Irf9−/− mice. Mice were housed under specific pathogen-free conditions according to Federation of European Laboratory Animal Science Associations (FELASA) guidelines. Mice were bred at the University of Veterinary Medicine Vienna according to the guidelines of the Federal Ministry of Science, Research and Economy section 8ff of the Animal Science and Experiments Act, Tierversuchsgesetz [TVG], BMWF-68.205/0068-WF/V/3b/2015. The study did not involve animal experiments as defined in the TVG and did not require ethical approval according to the local and national guidelines.
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