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B6 129s1 tlr3tm1flv j

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B6;129S1-Tlr3tm1Flv/J is a genetically modified mouse strain that has a targeted mutation in the Tlr3 gene, which encodes the Toll-like receptor 3 (TLR3) protein. TLR3 is involved in the recognition of double-stranded RNA, a molecular pattern associated with viral infection. This mouse strain is commonly used in research to study the role of TLR3 in immune responses and viral pathogenesis.

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Lab products found in correlation

C57bl 6j ticam1lps2 j, by Jackson ImmunoResearch (2 mentions) Ifnar b6.129s2 ifnar1tm1agt mmjax, by Jackson ImmunoResearch (2 mentions) C57bl 6 ot 2 b6 cg tg tcratcrb 425cbn j, by Jackson ImmunoResearch (2 mentions) Cby 129p2 b6 myd88tm1defr j, by Jackson ImmunoResearch (2 mentions) Il 1r b6.129s7 il1r1tm1imx j, by Jackson ImmunoResearch (2 mentions) C57bl 6, by Jackson ImmunoResearch (2 mentions) B6129sf2 j, by Jackson ImmunoResearch (1 mentions) Female balb c, by Charles River Laboratories (1 mentions) Cd 1 mice, by Charles River Laboratories (1 mentions) C57bl 6, by Charles River Laboratories (1 mentions)

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Tlr3tm1Flv/J (2 citations)

3 protocols using b6 129s1 tlr3tm1flv j

1

Mouse Strains for Immunological Studies

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B10.A and B10.A.SJL-Rag2−/− -Ptprca-5C.C7(TcRa, TcRb) were obtained from Taconic Farms (Germantown, NY). C57BL/6, C57BL/6 OT-II (B6.Cg- Tg (TcraTcrb) 425Cbn/J, Tram−/− C57BL/6J- Ticam1Lps2/J, TLR3−/− B6;129S1- Tlr3tm1Flv/J, MyD88−/− CBy.129P2(B6) - MyD88tm1Defr/J, IFNAR−/− B6.129S2- Ifnar1tm1Agt/Mmjax, IL-1R−/− B6.129S7-Il1r1tm1Imx/J were purchased from Jackson Laboratories (Bar Harbor, ME). All mice were housed under specific pathogen-free animal conditions at the National institute of Allergy and Infectious Diseases (NIAID), and used between 6 and 12 weeks of age in accordance with guidelines provided by the Institutional Animal Care and Use Committee of the NIAID.
Caucheteux S.M., Hu-Li J., Mohammed R., Ager A, & Paul W.E. (2016). Cytokine Regulation of Lung Th17 Response to Airway Immunization using LPS Adjuvant. Mucosal immunology, 10(2), 361-372.
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2

Mouse Models of Toll-Like Receptor Pathways

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Female BALB/c, C57BL/6 and CD-1 mice (4–6 weeks old) were obtained from Charles River Labs (St. Constant, PQ). TLR2 knockout mice had a C57BL/6 background and were a kind gift from Dr. Jean Marshall (Dalhousie University, NS, Canada). TLR3 knockout mice (B6;129S1-Tlr3tm1Flv/J) and wild type controls (B6;129SF2/J) were obtained from Jackson Laboratories (Bar Harbor, ME). Mice were housed under filter-top conditions and provided food and water ad libitum. Institutional animal care and use guidelines set by Carleton Animal Care Facility at Dalhousie University (Halifax, NS, Canada) were followed for all experiments. All experimental procedures performed during this study were approved by the Ethics Committee at Dalhousie University and strictly followed the guidelines set by The Canadian Council on Animal Care.
Weir G.M., Karkada M., Hoskin D., Stanford M.M., MacDonald L., Mansour M, & Liwski R.S. (2017). Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo. PLoS ONE, 12(6), e0180073.
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3

Mouse Strains for Immunological Studies

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B10.A and B10.A.SJL-Rag2−/− -Ptprca-5C.C7(TcRa, TcRb) were obtained from Taconic Farms (Germantown, NY). C57BL/6, C57BL/6 OT-II (B6.Cg- Tg (TcraTcrb) 425Cbn/J, Tram−/− C57BL/6J- Ticam1Lps2/J, TLR3−/− B6;129S1- Tlr3tm1Flv/J, MyD88−/− CBy.129P2(B6) - MyD88tm1Defr/J, IFNAR−/− B6.129S2- Ifnar1tm1Agt/Mmjax, IL-1R−/− B6.129S7-Il1r1tm1Imx/J were purchased from Jackson Laboratories (Bar Harbor, ME). All mice were housed under specific pathogen-free animal conditions at the National institute of Allergy and Infectious Diseases (NIAID), and used between 6 and 12 weeks of age in accordance with guidelines provided by the Institutional Animal Care and Use Committee of the NIAID.
Caucheteux S.M., Hu-Li J., Mohammed R., Ager A, & Paul W.E. (2016). Cytokine Regulation of Lung Th17 Response to Airway Immunization using LPS Adjuvant. Mucosal immunology, 10(2), 361-372.
+ Open protocol
+ Expand

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