Molecular structures of the materials (API’s, polymers, and biradical polarizing agents) used in our study are shown in Figure 1 . Copovidone Kollidon VA64, an amorphous random copolymer of 1-viny-2-pyrrolidone and vinyl acetate (60:40 mass ratio and 45–70 kDa molecular weight), was obtained from BASF. vinyl acetate (VA) was purchased from Polymer Source, Inc. The API clotrimazole and posaconazole were products of Spectrum Chemical Inc. and Merck Research Laboratories (MRL), respectively. TOTAPOL39 (link) and AMU-Pol40 are biradical polarizing agents and were both evaluated to enhance MAS NMR signal intensities. TOTAPOL was available from Dynupol, Inc., and AMUPOL was a gift from and Dr. Olivier Ouari and Prof. Paul Tordo (Aix-Marseille Université). Methanol (HPLC grade from Sigma-Aldrich) was used as a solvent for the spray-drying process. All chemicals were used as received.
Vinyl acetate
Manufactured by BASF
Sourced in Germany
Vinyl acetate is a colorless liquid chemical compound used in the production of various industrial products. It serves as a raw material in the manufacture of polyvinyl acetate and other vinyl polymers, which have a wide range of applications.
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2 protocols using vinyl acetate
1
Optimizing NMR Signal Intensity with Biradicals
2
RIV Crystals and Graft Copolymer SOL Synthesis
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RIV form I crystals with d90% of 52.7 μm (i.e., the portion of particles with diameters below 52.7 μm is 90%) measured via Malvern's Mastersizer 2000; Malvern, Malvern, UK) were kindly donated from Genepharm S.A. (Athens, Greece). The graft copolymer SOL (lot no. 84414368E0) containing 13% w/w PEG 6000, 57% w/w vinyl caprolactam and 30% w/w vinyl acetate, was obtained from BASF (Ludwigshafen, Germany). All other reagents used in the current study were of analytical or pharmaceutical grade and used as received.
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