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6 formylindolo 3 2 b carbazole ficz

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6-formylindolo[3,2-b]carbazole (FICZ) is a chemical compound used in laboratory research. It is a tryptophan photoproduct that acts as an endogenous ligand for the aryl hydrocarbon receptor (AhR). FICZ plays a role in the regulation of various biological processes.

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Lab products found in correlation

2 deoxyglucose 2 dg, by Merck Group (1 mentions) Dexamethasone (dex), by Merck Group (1 mentions) Amiloride hydrochloride hydrate, by Merck Group (1 mentions) Temsirolimus, by Merck Group (1 mentions) Ifnγ clone xmg1.2, by BioXCell (1 mentions) Ril 2, by BioLegend (1 mentions) Ril 21, by BioLegend (1 mentions) Ril 1β, by BioLegend (1 mentions) Ril 6, by BioLegend (1 mentions) Ril 23, by BioLegend (1 mentions) Ril 4, by BioLegend (1 mentions) Ch223191, by Cayman Chemical (1 mentions) Rtgf β1, by BioLegend (1 mentions) Anti icos clone c398.4a, by BioLegend (1 mentions)

2 protocols using 6 formylindolo 3 2 b carbazole ficz

1

Pharmacological Modulation of Cellular Pathways

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Amiloride hydrochloride hydrate, temsirolimus, 4,7-dimethyl-1,10-phenanthroline, 2-deoxyglucose (2DG), dichloroacetate (DCA), dexamethasone, and PGE2 were purchased from Sigma-Aldrich-Merck. Stemregenin 1 and 6-formylindolo[3,2-b]carbazole (FICZ) were purchased from Cayman Chemical Company.
Erra Díaz F., Ochoa V., Merlotti A., Dantas E., Mazzitelli I., Gonzalez Polo V., Sabatté J., Amigorena S., Segura E, & Geffner J. (2020). Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells. Cell reports, 31(5).
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2

Immunology Study in C57BL/6 Mice

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Mice were obtained from Japan SLC and maintained in specific pathogen-free conditions in our animal facility. All animal experiments were performed according to the protocols approved by the Institutional Animal Care and Use Committee at Waseda University (#2017-A007a, 2018-A090, 2019-A041, 2020-A057, 2021-A003, A22-007, and A23-007). We used 7- to 12-wk-old male or female C57BL/6 mice. Mouse rIL-1β, rIL-2, rIL-4, rIL-6, rIL-21, rIL-23, rTGF-β1, rCXCL13, and anti-ICOS (clone C398.4A) monoclonal Abs (mAbs) were obtained from BioLegend. Mouse rIL-12 and Cellstain CFSE (5- or 6-(N-Succinimidyloxycarbonyl)fluorescein 3’,6’-diacetate) were from Fujifilm Wako Pure Chemistry. mAbs to CD28 (clone 37.51), IL-2 (clone JES6-1A12), IL-4 (clone 11B11), IL-2Rα (clone PC-61.5.3), IL-2Rβ (clone TM-β1), and IFN-γ (clone XMG1.2) were from Bio X Cell. CH-223191, 6-formylindolo[3,2-b]carbazole (FICZ) and 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) were from Cayman Chemical.
Sakamoto R., Takada A., Yamakado S., Tsuge H., Ito E, & Iwata M. (2023). Release from persistent T cell receptor engagement and blockade of aryl hydrocarbon receptor activity enhance IL-6-dependent mouse follicular helper T-like cell differentiation in vitro. PLOS ONE, 18(6), e0287746.
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