Varenicline tartrate
Varenicline tartrate is a chemical compound used in the production of pharmaceutical products. It is a key ingredient in certain medication formulations. The core function of varenicline tartrate is to serve as an active pharmaceutical ingredient in the manufacturing process. No further details on intended use or application can be provided in an unbiased and factual manner.
Lab products found in correlation
6 protocols using varenicline tartrate
Synthesis and Formulation of Psychoactive Drugs
Pharmacological Manipulation of Nicotine Responses
Competitive ELISA for Nicotine Selectivity
Quantification of Desmoxan and Nicotine Metabolites
Structural Insights into 5-HTBP Binding with Varenicline
and purified as previously described.10 (link) A stock solution of varenicline tartrate (Sigma) was made in water
at a concentration of 500 mM and mixed with 6 mg/mL 5-HTBP to yield
a final varenicline concentration of 5 mM. Cryoprotection of the crystals
was achieved by equilibration of the mother liquor in 5% increments
of glycerol to a final concentration of 30% glycerol, and crystals
were immersed in liquid nitrogen prior to X-ray diffraction data collection.
The structure was determined by molecular replacement using the published
structure of 5-HTBP as the template (PDB: 2YMD). After placing the ligand into the electron
density map, the model of the complex was manually rebuilt and refined
through iterative cycles in Coot and Phenix. The final model has an Rwork value of 18.7% and Rfree value of 24.4%. Model validation was carried out in Molprobity,
and the model has a score of 1.75, which is in the 97th percentile
for this resolution range. Figures were prepared with Pymol.
Varenicline Sensitization and Conditioning
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