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Tucidinostat

Manufactured by Selleck Chemicals
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Sourced in United States

Tucidinostat is a histone deacetylase (HDAC) inhibitor used in laboratory research settings. It functions by inhibiting HDAC enzymes, which are involved in the regulation of gene expression. Tucidinostat is utilized by researchers to study cellular processes and signaling pathways.

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Lab products found in correlation

Dl sulforaphane, by Merck Group (1 mentions) Sk ut1 cell line, by American Type Culture Collection (1 mentions) Mes sa cell line, by American Type Culture Collection (1 mentions) Selinexor, by Selleck Chemicals (1 mentions) Hdac1, by Abcam (1 mentions) Hdac2, by Abcam (1 mentions) B cell lymphoma 2 bcl 2, by Abcam (1 mentions) Hdac3, by Abcam (1 mentions) Annexin 5 fitc apoptosis detection kit, by Thermo Fisher Scientific (1 mentions) Acetyl p53, by Abcam (1 mentions) Bcl2 associated x bax, by Abcam (1 mentions) Gapdh, by Abcam (1 mentions) Cyclin d1, by Abcam (1 mentions)

2 protocols using tucidinostat

1

Evaluating Effects of HDAC Inhibitors on Leiomyoma Cells

Cited 1 time
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The source and culture condition of human leiomyoma cell line (HuLM), uterine smooth muscle (UTSM) cell line, SK-UT1 cell line (ATCC, Manassas, VA, USA), and MES-SA cell line (ATCC, Manassas, VA, USA) were described previously [27 (link)].
Class I HDAC inhibitor Tucidinostat was purchased from Selleck Chemical (Cat# S8567, Houston, TX, USA). DL-sulforaphane was purchased from Sigma-Aldrich (Cat# S4441, Saint Louis, MO, USA). The range of doses tested was 1–25 µM.
Yang Q., Falahati A., Khosh A., Mohammed H., Kang W., Corachán A., Bariani M.V., Boyer T.G, & Al-Hendy A. (2022). Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma. Cells, 11(23), 3801.
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2

Apoptosis Analysis of HDAC and XPO1 Inhibitors

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Tucidinostat (dissolved in DMSO as 50mg/ml) and selinexor (dissolved in DMSO as 50mg/ml) were obtained commercially from Selleckchem (Houston, TX, USA). Annexin V-FITC apoptosis detection kit was obtained from eBioscience (San Diego, CA, USA). The antibodies of HDAC1, HDAC 2, HDAC3, XPO1, acetyl-p53, p53, p21, Cyclin D1, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X (Bax) and GAPDH were purchased from abcam (Cambridge, UK).
Shi Y., Xu S, & Li S. (2022). Selinexor improves the anti-cancer effect of tucidinostat on TP53 wild-type breast cancer. Molecular and cellular endocrinology, 545.
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