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Tyrphostin ag1024

Manufactured by Merck Group
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Tyrphostin AG1024 is a tyrosine kinase inhibitor. It functions by selectively inhibiting the activity of the insulin-like growth factor 1 receptor (IGF-1R) and the epidermal growth factor receptor (EGFR).

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Lab products found in correlation

Dansylcadaverine, by Merck Group (1 mentions) Nvp aew541, by Novartis (1 mentions) Sonidegib, by Selleck Chemicals (1 mentions) Corn oil, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)

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AG1024

2 protocols using tyrphostin ag1024

1

IGF1 Signaling Pathways Modulation

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Cells were serum-starved for 24 hr, after which they were treated with 50 ng/ml of IGF1 (PeproTech Ltd., Rocky Hill, NJ) and/or 300 micromolar of dansylcadaverine (Sigma-Aldrich) for different time periods. In addition, cells were treated with the following specific IGF1R inhibitors: tyrosine kinase inhibitor NVP-AEW541 (2 micromolar) (Novartis) or tyrphostin AG1024 (1 micromolar) (Sigma-Aldrich).
Solomon-Zemler R., Sarfstein R, & Werner H. (2017). Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells. PLoS ONE, 12(9), e0185164.
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2

Inhibiting IGF-1 and Hedgehog Pathways

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Some mice (N=3) were administered the IGF-1 inhibitor Tyrphostin AG1024 (Sigma) daily beginning on the day of hydrogel implantation for 21 days. AG1024 (30µg) was delivered in DMSO (3µL) (Sigma) and PBS (200µL) via an IP injection. Vehicle group received DMSO in PBS via an IP injection daily for 21 days. Other mice (N = 3) were administered 10mg/kg/day of Sonidegib (0.25mg; Selleck Chemicals) in 2% DMSO (Sigma) and corn oil (Sigma) for 21 days for the treatment group or 2% DMSO in corn oil for vehicle group via an IP injection. The first dose was administered on the day of hydrogel implantation and continued daily for 21 days. Hydrogels and surrounding tissues were excised and RNA was isolated.
Samples were then assayed for gene expression via RT-qPCR.
Androschuk A.M., Tam T.H., Mahou R., Lo C., Salter M.W, & Sefton M.V. (2022). Methacrylic acid-based biomaterials promote peripheral innervation in the subcutaneous space of mice. Biomaterials, 289.
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