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Cb17 prkdcscid j

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The CB17-Prkdcscid/J is a laboratory mouse strain that is severely immunodeficient due to a mutation in the Prkdc gene. This strain is often used as a model for human severe combined immunodeficiency (SCID) in research applications.

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Lab products found in correlation

B6.129p2 il4tm1cgn j, by Jackson ImmunoResearch (1 mentions) Ifnγr b6.129s7ifngr j, by Jackson ImmunoResearch (1 mentions) Inos b6.129p2 nos2tm1lau j, by Jackson ImmunoResearch (1 mentions) Balb c, by Jackson ImmunoResearch (1 mentions) C57bl 6j, by Jackson ImmunoResearch (1 mentions) Nod scid, by Jackson ImmunoResearch (1 mentions) Nod shiltj, by Jackson ImmunoResearch (1 mentions)

3 protocols using cb17 prkdcscid j

1

Mouse Breeding and Maintenance Protocols

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Two to four month old male and female mice, bred and maintained at Rider University, were handled in accord with NIH, Animal Welfare Act, and Rider University IACUC guidelines. Breeding pairs of C57BL/6J, BALB/c, CB17-Prkdcscid/J, IFNγR−/− (B6.129S7Ifngr/J), iNOS−/− (B6.129P2-Nos2tm1Lau/J), and IL4−/− (B6.129P2-IL4tm1Cgn/J) mice were obtained from the Jackson Laboratory, Bar Harbor, ME.
Goldman N., Valiuskyte K., Londregan J., Swider A., Somerville J, & Riggs J.E. (2017). Macrophage regulation of B cell proliferation. Cellular immunology, 314, 54-62.
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2

Genetic Comparison in SCID Mice

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Male SCID mice (CB17-Prkdcscid/J) were purchased from the Jackson Laboratory. C57BL/6 wild-type and Sphk2−/− mice were from R. Proia (NIH). Three-month-old male mice with littermate controls to assure the same genetic background were used for all experiments. Animal procedures were approved by the Institutional Animal Care and Use Committee at Virginia Commonwealth University.
Hait N.C., Wise L.E., Allegood J.C., O’Brien M., Avni D., Reeves T.M., Knapp P.E., Lu J., Luo C., Miles M.F., Milstien S., Lichtman A.H, & Spiegel S. (2014). Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. Nature neuroscience, 17(7), 971-980.
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3

NOD Mouse Model for Autoimmune Disease

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Male and female NOD/ShiLtJ (NOD), castrated and sham-castrated male NOD, and NOD.CB17-Prkdc scid /J (non-obese diabetic-severe combined immunodeficient; NOD-SCID) mice were purchased from The Jackson Laboratory (Bar Harbor, ME). NOD mice expressing the bicistronic Foxp3-green fluorescent protein (Foxp3 GFP ) reporter construct knocked into the endogenous Foxp3 locus 11 (NOD), were a kind gift from Vijay Kuchroo (Harvard University, Cambridge, MA) and were previously described. 12 Mice used for phenotypic analyses of salivary gland infiltrating cells were 14-to 15-week-old females and 19-to 21-week-old males. Donor and recipient mice for transfer studies were 6-12 weeks old. Mice used for in vivo CD25 depletion studies were 5-6 weeks old at the start of antibody treatment. Mice were maintained and used in accordance with the Institutional Animal Care and Use Committee Guidelines of the University of Iowa and the Children's Hospital of Philadelphia.
Barr J.Y., Wang X., Kreiger P.A, & Lieberman S.M. (2018). Salivary-gland-protective regulatory T-cell dysfunction underlies female-specific sialadenitis in the non-obese diabetic mouse model of Sjögren syndrome. Immunology, 155(2).
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