Dexamethasone dex

Manufactured by MedChemExpress

Sourced in United States

Dexamethasone (Dex) is a synthetic glucocorticoid, a class of steroid hormones. It is a potent anti-inflammatory and immunosuppressant agent. Dexamethasone is used in a variety of research applications, including the study of inflammation, immune function, and cellular signaling pathways.

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Lab products found in correlation

D galactosamine d galn, by Merck Group (1 mentions) Lipopolysaccharide lps, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) D limonene, by Merck Group (1 mentions) β actin, by Bioworld Technology (1 mentions) Fetal bovine serum (fbs), by Boster Bio (1 mentions) Isobutylmethylxanthine ibmx i7018, by Merck Group (1 mentions) Mitotracker red cmxros, by Solarbio (1 mentions) Penicillin streptomycin, by Boster Bio (1 mentions) Phospho ampkα thr172, by Cell Signaling Technology (1 mentions) Oil red o staining kit, by Solarbio (1 mentions) Trypsin, by Boster Bio (1 mentions) Ampkα, by Cell Signaling Technology (1 mentions)

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Dexamethasone (17 citations)

2 protocols using dexamethasone dex

Investigating Inflammatory Pathways in Liver Injury

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Lipopolysaccharide (LPS, #L2630), D-galactosamine (D-GalN, #12,662) and Dimethyl sulfoxide (DMSO, #41,640) were procured from Sigma, St Louis, USA to be used as reagents. Dexamethasone (Dex, #14,648) was purchased from MedChemExpress. The source of 8 standard sample was as follows: Myrcene (CAS: 123-35-3, LOT: X30A11S122905, Shanghai Yuanye Biotech); D-limonene (CAS: 5989-27-5, LOT: 1,012,026,665, Sigma-Aldrich); γ-terpinene (CAS: 99-85-4, LOT: A29J11L119842, Shanghai Yuanye Biotech); 4-Carvomenthenol (CAS: 562-74-3, LOT: J13A9S58322, Shanghai Yuanye Biotech); α-Terpineol (CAS: 98-55-5, LOT: J28J7S9465, Shanghai Yuanye Biotech); β-elemene (CAS: 515-13-9, LOT: J14GB154783, Shanghai Yuanye Biotech); β-Caryophyllene (CAS: 87-44-5, LOT: A05GB156905, Shanghai Yuanye Biotech); Germacrene D (CAS: 23986-74-5, LOT: G367765, Toronto Research Chemicals). Furthermore, a range of antibodies against markers like β-actin (#4967), TBK1 (#3013), phospho-TBK1 (#5483), TAK1 (#5206), phospho-TAK1 (#9339), IRF3 (#4302), phospho-IRF3 (#29,047), IKK (#2370), phospho-IKK (#2697), IκB (#4812), phospho-IκB (#2859), NF-κB p65 (#4764), phospho-NF-κB p65 (#3033), p38 (#9212), phospho-p38 (#9211), JNK (#3708), phospho-JNK (#4668), ERK (#9102), phospho-ERK (#9101), F4/80 (#2370), CD68 (ab125212), TLR4 (ab9105), MyD88 (ab219413), and TRIF (ab13810) were obtained from Cell Signaling Technology or Abcam.

Lan T., Wang W., Huang D.L., Zeng X.X., Wang X.X., Wang J., Tong Y.H., Mao Z.J, & Wang S.W. (2023). Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response. Natural Products and Bioprospecting, 13(1), 36.

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Adipocyte Browning Regulation Assay

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Fetal bovine serum (FBS; PYG0001), Dulbecco's modified Eagle's medium (DMEM; PYG0073), dimethyl sulfoxide (DOSO; PYG0040), ELC western blot detection kits (AR1171), penicillin/streptomycin (PYG0016), and trypsin (PYG0015) were purchased from Boster Biotechnology (Pleasanton, CA, USA). Oil Red O staining kit (#1262) and Mito Tracker Red CMXRos (M9940) were purchased from Solarbio (Beijing, China). RIPA lysis buffer (HY-K1001), insulin (HY-P1156), 5-Aminoimidazole-4-carb-oxyamide ribonucleoside (AICAR; HY-13417), rosiglitazone (Ros; HY-17386), STO-609 (HY-19805), BAPTA-AM (HY-100545), dorsomorphin (HY-13418A), and dexamethasone (DEX; HY-14648) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Isobutylmethylxanthine (IBMX; I7018) was purchased from Sigma-Aldrich (St. Louis, MO, USA). Antibody sources are as follows: Ucp-1 (A5857, ABclonal, Woburn, MA, USA; 1:1,000, 32 kDa), peroxisome proliferator-activated receptor γ coactivator (Pgc-1α; BS91062, Bioworld, Nanjing, China; 1:1,000, 113 kDa), phospho-AMPKα (Thr172) (#2535, Cell Signaling Technology, Danvers, MA, USA; 1:1,000, 62 kDa), AMPKα (#5831, Cell Signaling Technology; 1:1,000, 62 kDa), and β-actin (AP0060, Bioworld; 1:6,000, 42 kDa).

Ma B., Hao J., Xu H., Liu L., Wang W., Chen S, & Wu H. (2022). Rutin promotes white adipose tissue "browning" and brown adipose tissue activation partially through the calmodulin-dependent protein kinase kinase β/AMP-activated protein kinase pathway. Endocrine journal, 69(4).

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