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Peg 200

Manufactured by Electron Microscopy Sciences
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Sourced in United States

PEG 200 is a polyethylene glycol with an average molecular weight of approximately 200 g/mol. It is a viscous, colorless liquid that is miscible with water and many organic solvents. PEG 200 is commonly used as a solvent, plasticizer, and surfactant in various applications.

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Lab products found in correlation

Cremophore el, by Merck Group (2 mentions) Am630, by Merck Group (1 mentions) Cremophor el, by Merck Group (1 mentions) Gw842166x, by Cayman Chemical (1 mentions) Gw842166x, by Merck Group (1 mentions) 6 ohda, by Merck Group (1 mentions) Am630, by Cayman Chemical (1 mentions) Picrotoxin, by Merck Group (1 mentions) Sterile saline, by Merck Group (1 mentions) H89 dihydrochloride, by Bio-Techne (1 mentions) 6 cyano 7 nitroquinoxaline 2 3 dione disodium salt, by Bio-Techne (1 mentions) R cpp, by Bio-Techne (1 mentions)

3 protocols using peg 200

1

6-OHDA Model of Parkinson's Disease

Cited 1 time
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The sources of chemicals were the following: 6-OHDA, (Sigma-Aldrich, St. Louis, MO, USA); GW842166X and AM630, (Cayman Chemical Company, Ann Arbor, MI, USA. 35% PEG 200 (Electron Microscopy Sciences, Hatfield, PA, USA), 10% cremophor EL (Sigma-Aldrich, St. Louis, MO, USA), and 55% sterile saline with gentle heating was used as the vehicle for GW842166X and AM630 [49 (link)]. All other common chemicals were obtained from Sigma-Aldrich (St. Louis, MO, USA).
Liu X., Yu H., Chen B., Friedman V., Mu L., Kelly T.J., Ruiz-Pérez G., Zhao L., Bai X., Hillard C.J, & Liu Q.S. (2022). CB2 Agonist GW842166x Protected against 6-OHDA-Induced Anxiogenic- and Depressive-Related Behaviors in Mice. Biomedicines, 10(8), 1776.
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2

Cocaine HCl and Ibudilast Administration

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All reagents were freshly prepared. Cocaine HCl (NIDA Drug Supply Program, RTI, NC) was dissolved in sterile saline. Ibudilast (AvaChem, San Antonio, Tx) was dissolved in 35% PEG 200 (Electron Microscopy Sciences, Hatfield, PA), 10% Cremophore EL (Sigma-Aldrich, St. Louis, MO), and 55% sterile saline with gentle heating and cooling.
Poland R.S., Hahn Y., Knapp P.E., Beardsley P.M, & Bowers M.S. (2016). Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats. Neuropharmacology, 109, 281-292.
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3

Cocaine HCl and Ibudilast Preparation

Cited 1 time
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Cocaine HCl and ibudilast were provided by the NIDA Drug Supply Program. Cocaine was dissolved in sterile saline (Midwest Veterinary Supply, Sun Prairie, WI), diluted to unit doses appropriate for behavioral studies, and filtered through a 0.2 μm membrane prior to use. Ibudilast was first dissolved in PEG 200 (final concentration 35%, Electron Microscopy Sciences, Hatfield, PA), then further mixed with 10% Cremophore EL (Sigma-Aldrich), and 55% sterile saline with gentle heating (Poland et al., 2016 (link)). Picrotoxin and all other common chemicals were obtained from Sigma-Aldrich (St. Louis, MO). 6-cyano-7-nitroquinoxaline-2,3-dione disodium salt, (R)-CPP and H89 dihydrochloride were obtained from Tocris Bioscience (Ellisville, MO).
Mu L., Liu X., Yu H., Hu M., Friedman V., Kelly T.J., Zhao L, & Liu Q.S. (2021). Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology, 201, 108830.
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