Acetonitrile lichrosolv hypergrade

All of the reference pharmaceutical standards were classified as analytical grade (>98 %). ²H₆-amitriptyline, ²H₁₀-carbamazepine, ¹³C₃¹⁵N-ciprofloxacin, ¹³C₂-ethinyl estradiol, ²H₅-fluoxetine, ¹³C₆-sulfamethoxazole, ¹³C²H₃-tramadol, and ¹³C₃-trimethoprim were obtained from Cambridge Isotope Laboratories (USA). ²H₅-oxazepam, ²H₄-risperidone, and ¹³C₂¹⁵N-tamoxifen were purchased from Sigma-Aldrich (Germany). ²H₆-codeine, ²H₄-diclofenac, ²H₄-flecainide, ²H₃-ketoprofen, ¹³C₃²H₃-naproxen, and ²H₃-paracetamol were purchased from CDN-Isotopes (Canada).
LC/MS grade methanol and acetonitrile (LiChrosolv–hypergrade) were purchased from Merck (Germany). Purified water was prepared using a Milli-Q Advantage system, including an ultraviolet radiation source (Millipore, USA).

RPV free-base powder and RPV LA NS (RPV LA 300 mg/mL) were supplied by Janssen Pharmaceutica (Beerse, Belgium). CAB free acid and CAB LA NS (CAB LA 200 mg/mL) were supplied by ViiV Healthcare Ltd. (Research Triangle Park, North Carolina, United States). Poly(vinyl alcohol) (PVA) 9–10 kDa (80% hydrolysed), PVA 31–50 kDa, trifluoroacetic acid (TFA) (> 99%), and D-mannitol (> 98%) were purchased from Sigma-Aldrich (Gillingham, Dorset, United Kingdom). Poly(vinylpyrrolidone) (PVP) 58 kDa, PVP 360 kDa, were provided by Ashland (Kidderminster, United Kingdom). Dimethyl sulfoxide (DMSO) and glycerol bidistilled, AnalaR NORMAPUR® analytical reagent (99.5%) were purchased from VWR International (Leicestershire, United Kingdom). Pluronic® F-108 (PF108) was purchased from BASF SE (Ludwigshafen, Germany). Poly(lactic acid) Silver Metallic (9088) was supplied by Ultimaker (Geldemalsen, Netherlands). Acetonitrile LiChrosolv® hypergrade was purchased from Merck (Darmstadt, Germany). Ultrapure water was obtained from a water purification system, the Elga PURELAB DV-25, from Veolia Water Systems (Celbridge, Ireland). All other chemicals were of analytical reagent grade and purchased from standard industrial suppliers.