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Fviiai

Manufactured by Novo Nordisk
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FVIIai is a laboratory reagent used in diagnostic testing. It contains recombinant activated factor VII, which is a key component in the blood coagulation cascade. FVIIai can be used to assess the function and activity of the extrinsic pathway of the coagulation system.

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Lab products found in correlation

P scn bn nota, by Macrocyclics (1 mentions) Pd 10 desalting column, by GE Healthcare (1 mentions) Solid phase extraction cartridges, by Waters Corporation (1 mentions)

2 protocols using fviiai

1

Radiolabeling of FVIIai with 64Cu

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All chemicals were obtained from Sigma Aldrich unless stated otherwise. FVIIai was obtained from Novo Nordisk A/S. p-SCN-Bn-NOTA was purchased from Macrocyclics. 64 Cu was produced by The Hevesy Laboratory at DTU Nutech using the 64 Ni(p,n) 64 Cu reaction and obtained in a dried formulation.
Nielsen C.H., Jeppesen T.E., Kristensen L.K., Jensen M.M., El Ali H.H., Madsen J., Wiinberg B., Petersen L.C, & Kjaer A. (2016). PET Imaging of Tissue Factor in Pancreatic Cancer Using 64Cu-Labeled Active Site-Inhibited Factor VII. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 57(7).
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2

FVIIa Inactivation and Assay

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All chemicals were obtained from Sigma Aldrich unless stated otherwise. FVIIai was from Novo Nordisk A/S and was obtained by inactivation of FVIIa with phenylalanine-phenylalanine-arginine-chloromethyl ketone as previously described (16) . Gly-gly buffer consisted of 10 mM gly-gly, 150 mM NaCl, and 10 mM CaCl 2 , adjusted to pH 7.5. 4-(ethoxycarbonyl)-N,N,N-trimethylbenzenaminium triflate was purchased from ABX. Solidphase extraction cartridges were obtained from Waters. The PD-10 desalting column was obtained from GE Healthcare. All chemicals were used without further purification.
Nielsen C.H., Erlandsson M., Jeppesen T.E., Jensen M.M., Kristensen L.K., Madsen J., Petersen L.C, & Kjaer A. (2016). Quantitative PET Imaging of Tissue Factor Expression Using 18F-Labeled Active Site-Inhibited Factor VII. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 57(1).
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