Hexafluoroisopropanol hfip

All chemicals were used as provided without further purification unless noted otherwise. Tetrahydrofuran, triethylamine, oxalyl chloride, propargyl amine, sodium ascorbate, neocuproine, hexa (ethylene glycol) dithiol, glycerol ethoxylate, PEG 600 diol and hexafluorobenzene were purchased from Sigma Aldrich. Deuterobenzene, deuterated dimethyl sulfoxide and deuterochloroform were purchased from Cambridge Isotope Laboratories (CIL). Copper(ii) acetate was obtained from Acros Organics and 2,2-dimethoxy-2-phenylacetophenone (DMPA) from TCI. TBTA was synthesized following a previously published procedure.⁴³ Perfluorotripropylamine (FC 3283), methoxyperfluorobutane (HFE 7100), 2-(trifluoromethyl)-3-ethoxydodecafluorohexane (HFE 7500) and Krytox FSH were obtained from Miller-Stephenson. Acetonitrile (MeCN) was obtained from EMD and hexafluoroisopropanol (HFIP) from Alfa-Aesar. Thiourea was purchased from Chem-Impex International and ethanol, methanol, sodium hydroxide and hydrochloric acid were obtained from Macron Fine Chemicals.

The solid support (resin Rink-Amide MBHA) and the Fmoc protected amino acids were from Novabiochem (Merck KGaA, Darmstadt, Germany). The coupling reagents 2-(1H –Benzotriazole-1-yl) -1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) and 1-Hydroxybenzotriazole (HOBt) were from Advanced Biotech (Seveso, MI, Italy). N,N-diisopropylethylamine (DIEA) and piperidine were from Biosolve (Leenderweg, Valkenswaard, Netherlands). Triethoxysilane (TES), were from Sigma-Aldrich (Steinheim, Germany). Solvents such as N,N-dimethylformamide (DMF), trifluoroacetic acid (TFA), N-methyl-2-pyrrolidone (NMP) and dichloromethane (DCM) were from Biosolve (Leenderweg, Valkenswaard, Netherlands). The solvent for electrospinning solutions hexafluoroisopropanol (HFIP) was from Alfa Aesar (Ward Hill, MA, USA). Poly-ε-caprolactone, average M_n ca. 60,000 (PCL) used to produce the electrospun scaffolds was from Aldrich (St. Louis, MO, USA).