Cardiolab system

Manufactured by GE Healthcare

The Cardiolab System is a comprehensive solution for cardiac diagnostics and imaging. It provides advanced tools for data acquisition, analysis, and reporting of cardiac-related measurements and images. The system is designed to support a wide range of cardiac procedures and clinical workflows.

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Lab products found in correlation

α chloralose, by Merck Group (1 mentions) Pentaray nav catheter, by Johnson & Johnson (1 mentions) Carto 3 system, by Johnson & Johnson (1 mentions)

5 protocols using cardiolab system

Cardiac Electrophysiology Experiments in Large Animals

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All experiments were carried out in purpose built large animal translational cardiac catheterization laboratories (Siemens, Erlangen, Germany) at the Cardiovascular Innovation Laboratory at Mayo Clinic, Rochester, MN, USA (canine studies) and the Cardiovascular Animal Research Center in the Laboratory for Advanced Cardiovascular and CNS Interventions at the School of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic (porcine studies). Electrophysiological studies were performed using the Cardiolab System (6.8.1 release 2, GE Healthcare, Wauwatosa, Wisconsin) using standard cardiac stimulators. Regular bipolar configurations between electrodes arranged in parallel between lead arms (1–2, 3–4, 5–6 and 7–8) or serially along each arm (1 (link)–3 (link), 2 (link)–4 (link), 1 (link)–5 (link)) were used (Figure 3). Sensed signals were gained 500 times and processed with 30 – 500 Hz band pass and 60 Hz notch filters.

Syed F.F., DeSimone C.V., Ebrille E., Gaba P., Ladewig D.J., Mikell S.B., Suddendorf S.H., Gilles E.J., Danielsen A.J., Lukášová M., Wolf J., Leinveber P., Novák M., Stárek Z., Kara T., Bruce C.J., Friedman P.A, & Asirvatham S.J. (2015). Percutaneous Epicardial Pacing using a Novel Insulated Multi-electrode Lead. JACC. Clinical electrophysiology, 1(4), 273-283.

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Cardiac Electrophysiology Monitoring Protocol

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Experiments were performed in dedicated large-animal translational electrophysiology laboratories at Mayo Clinic, Rochester, Minnesota and at St Anne’s University Hospital, Brno, Czech Republic. Electrocardiography recordings were performed using the Cardiolab System (version 6.8.1 release 2, GE Healthcare, Wauwatosa, Wisconsin). High and low pass filters were set at 0.05Hz and 100Hz, respectively. Sensed signals were gained at 2500 times as standard.

Killu A.M., Naksuk N., Stárek Z., DeSimone C.V., Syed F.F., Gaba P., Wolf J., Lehar F., Pesl M., Leinveber P., Crha M., Ladewig D., Powers J., Suddendorf S., Hodge D.O., Satam G., Novák M., Kara T., Bruce C.J., Friedman P.A, & Asirvatham S.J. (2017). A Novel Defibrillation Tool: Percutaneously Delivered, Partially Insulated Epicardial Defibrillation. JACC. Clinical electrophysiology, 3(7), 747-755.

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Post-MI Anesthesia and Euthanasia Protocol

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Six to eight weeks post-MI, animals were sedated, intubated, and placed under anesthesia with isoflurane (1–2% INH). After completion of the surgical procedures, including sternotomy, anesthesia was transitioned to α-chloralose (Sigma-Aldrich; 50 mg/kg initial bolus, then 20–35 mg/kg/hr IV). Depth of anesthesia was adjusted based on hemodynamic indices, corneal reflex, and jaw tone. Arterial blood gases were monitored throughout the experiments; ventilation adjusted, or sodium bicarbonate was administered to maintain normal pH. The CardioLab System (GE Healthcare) was used to record continuous 12-lead electrocardiograms. Ventral precordial leads were placed posteriorly given sternotomy. The femoral and carotid arteries were cannulated to measure blood pressure continuously and obtain access to the left ventricle (LV) for basket catheter placement, respectively. Sheaths were placed in the femoral veins for delivery of medications and saline. Fentanyl boluses (20–30 mcg/kg) were used during sternotomy to reduce discomfort. Sodium pentobarbital (Med-Pharmex Inc.; 100 mg/kg IV) followed by saturated KCl (Sigma-Aldrich; 1–2 mg/kg IV) was used for euthanasia.

Hoang J.D., Yamakawa K., Rajendran P., Chan C.A., Yagishita D., Nakamura K., Lux R.L, & Vaseghi M. (2022). Pro-arrhythmic Effects of Sympathetic Activation Are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts. JACC. Clinical electrophysiology, 8(4), 513-525.

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Scar-related VT Ablation Techniques

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Scar-related VT ablation procedures were performed using standard ablation techniques^{2 (link)}, or infusion-needle catheter ablation^{25 (link)}. Use of the needle catheter was conducted through the Special Access Program, Health Canada. VT was induced by programmed ventricular stimulation from the right ventricular (RV) apex or outflow tract and the LV was mapped via the retrograde aortic or trans-septal atrial approach. Intracardiac electrograms were digitized and stored by CardioLab system (GE Healthcare, Barrington, Illinois), and three-dimensional (3D) electroanatomic (EA) maps were acquired by the Carto 3 system (Biosense Webster, Irvine, California). Substrate-based mapping and pace-mapping were used to identify scar and potential culprit sites within the scar, which were targeted for ablation. For each procedure, a complete LV endocardial EA map was created using a 3.5-mm tip irrigated catheter (Navistar SmartTouch, Biosense Webster, Diamond Bar, CA, USA) or a high-density multi-electrode catheter (PentaRay NAV Catheter, Biosense Webster). Pacing was performed with stable catheter position at multiple endocardial sites at minimum pacing output that ensured consistent focal myocardial capture.

Zhou S., AbdelWahab A., Horáček B.M., MacInnis P.J., Warren J.W., Davis J.S., Elsokkari I., Lee D.C., MacIntyre C.J., Parkash R., Gray C.J., Gardner M.J., Marcoux C., Choudhury R., Trayanova N.A, & Sapp J.L. (2020). Prospective Assessment of An Automated Intraprocedural 12-lead ECG-Based System for Localization of Early Left Ventricular Activation. Circulation. Arrhythmia and electrophysiology, 13(7), e008262.

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ECG Morphology Analysis in LPF-VT

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SR and LPF-VT ECG morphology were measured on the 12-lead ECG with electronic calipers on the CardioLab system (GE Medical Systems; Houston, TX) or Bard (Bard Electrophysiology, Lowell, MA) recording system. Standard 12-lead ECG electrode placement was used. Lead gain was uniform with paper speed of 100 mm/s. During the clinical arrhythmia, the following measurements were obtained during LPF-VT: (1) R-and S-wave amplitudes and ratio of R/S in leads I and V6; (2) QRS duration; and (3) QRS frontal axis. The T-P segment was considered the isoelectric baseline for measurement of R-and S-wave amplitudes. The QRS duration was measured from the site of earliest initial deflection from the isoelectric line in any lead to the time of latest activation in any lead. The ECG data were measured with electronic calipers by 2 experienced investigators blinded to the site of the origin. If there were discrepancies between those results, they were adjudicated by a third investigator.

Ma W., Lu F., Shehata M., Wang X., Zhang F., Chen B., Wu D., He L., Sun S., Cheng A., Ding J., Cong H, & Xu J. (2017). Catheter Ablation of Idiopathic Left Posterior Fascicular Ventricular Tachycardia: Predicting the Site of Origin via Mapping and Electrocardiography. Circulation. Arrhythmia and electrophysiology, 10(11).

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