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Tim trio

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The TIM Trio is a multi-purpose lab equipment designed to assist in various laboratory tasks. It functions as a temperature-controlled incubator, mixer, and timer, providing a versatile solution for maintaining optimal conditions for samples and experiments.

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Lab products found in correlation

Discovery a, by Hologic (1 mentions) Mr750, by Siemens (1 mentions) Tim trio, by Siemens (1 mentions) Signa lx, by GE Healthcare (1 mentions) Discovery a densitometer, by Hologic (1 mentions) Mr750, by GE Healthcare (1 mentions)

5 protocols using tim trio

1

Comprehensive body composition assessment

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Trained technicians obtained measurements of height, weight, circumferences of the waist and hip, and chest depth [12 (link)]. 3T MRI scanners (Siemens TIM Trio at UH and General Electric HDx at USC) were used. An abdominal scan was acquired to quantify VAT areas (square centimeters) at 4 intervertebral segments of the intra-abdominal cavity (L1–L2, L2–L3, L3–L4, L4–L5) using an axial gradient-echo sequence with breath holds [12 (link)]. The average VAT across the segments L1-L5 was used in analysis. Whole-body composition, including total fat mass and muscle mass, was determined by a DXA scan (Hologic Discovery A fan-beam densitometer at UH and USC, Bedford, MA) [12 (link)]. Extensive details regarding the imaging protocol, as well as quality control calibration and estimation of VAT and SAT area were previously published [12 (link)].
Streicher S.A., Lim U., Park S.L., Li Y., Sheng X., Hom V., Xia L., Pooler L., Shepherd J., Loo L.W., Ernst T., Buchthal S., Franke A.A., Tiirikainen M., Wilkens L.R., Haiman C.A., Stram D.O., Cheng I, & Le Marchand L. (2023). Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study. PLOS ONE, 18(1), e0279932.
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2

Multisite fMRI Imaging Acquisition Protocol

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All fMRI scans were conducted on 3 T scanners at Yale University, Columbia University, or University of California at Davis on the following scanners respectively: 3 T Siemens TIM TRIO, 3 T GE MR750, and 3 T Siemens TIM TRIO. All sites used a 32-channel head coil. The same scanning parameters were used across all sites (detailed scanner specifications can be found in Javitt et al., 2018 (link)). Briefly, before initial resting state scans, high-resolution T1*weighted anatomical images were acquired for image registration (TR = 1900 ms, TE = 2.98 ms, TI = 1100 ms, matrix = 256 × 256, FOV = 256 mm, voxel size = 1.0 × 1.0 × 1.0mm). Then for both pre-drug baseline and post-drug functional imaging, 32 axial-oblique slices were obtained in an interleaved pattern (TR = 200 ms, TE = 30.0ms, FOV = 220 mm, matrix = 64*64, slice thickness = 4 .0mm, one voxel = 3.4 × 3.4 × 4.0mm).
Fleming L.M., Javitt D.C., Carter C.S., Kantrowitz J.T., Girgis R.R., Kegeles L.S., Ragland J.D., Maddock R.J., Lesh T.A., Tanase C., Robinson J., Potter W.Z., Carlson M., Wall M.M., Choo T.H., Grinband J., Lieberman J., Krystal J.H, & Corlett P.R. (2019). A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms. NeuroImage : Clinical, 22, 101739.
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3

Diffusion Tensor Imaging at 1.5T and 3T

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7 patients were imaged at our institution, of which 3 were imaged a 3T (Siemens Tim Trio) and 4 patients at 1.5T (GE Signa LX) MRI systems. For these patients, both the baseline and follow up MRI studies were performed on the same MRI scanner. The 3T Diffusion Tensor Imaging (DTI) sequence consisted of, 75 slices of thickness 2.0mm with b value = 1000s/mm2 in 64 non-colinear directions were collected (TR/TE 9500/93ms, FoV (19.2cm2), matrix 96x96, 1 average) with 8 images with b value = 0s/mm2. The diffusion trace-weighted image and the corresponding Mean Diffusivity (MD) map were generated by the scanner. At 1.5T, DWI was performed using a single-shot echo-planar technique (TE 101ms, TR 10000ms, one average, matrix 96 x 128, FOV 26 x 26cm, slice thickness 5mm) with diffusion-weighting factors (‘b values’) of 0 and 1000 sec/mm2 applied sequentially along three orthogonal axes.
Eisenmenger L., Porter M.C., Carswell C., Thompson A., Mead S., Rudge P., Collinge J., Jäger R, & Hyare H. (2016). Diffusion-weighted MRI signal abnormality in sporadic CJD increases in extent and intensity with disease duration. JAMA neurology, 73(1), 76-84.
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4

Liver Fat Quantification Using MRI

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The MRI scanners Siemens TIM Trio at UH and General Electric HDx at USC, both with a 3‐tesla magnetic field strength, were used to quantify liver fat. The MRI protocol assessed four abdominal intervertebral segments of the intra‐abdominal cavity (L1‐L2, L2‐L3, L3‐L4, L4‐L5) and did not include the intrathoracic or intrapelvic cavity. Percent liver fat was estimated from a series of axial triple gradient‐echo Dixon‐type scans (10‐mm slices, no gap; echo time, 2.4, 3.7, and 5.0 milliseconds; repetition time, 160 milliseconds; 25‐degree flip angle) by analyzing in‐phase, out‐of‐phase, and in‐phase signals in a circular region of interest (ROI; 20 cm2) in the lateral right lobe of the liver that was manually selected to avoid intrahepatic vessels and bile ducts.(19) Additional details regarding the protocol can be found in Lim et al.(16) We selected two ROIs for each participant and repeat scanned each ROI, the average of which was used for the estimation of liver fat. NAFLD was defined as percent liver fat of 5.5% or greater excluding subjects with excessive alcohol consumption defined as >30 g/day of alcohol in men and >20 g/day of alcohol in women in the past year.(20) Body fat distribution was determined by a whole‐body DXA scan (Hologic Discovery A densitometer; Bedford, MA). Total fat mass (kg) was estimated for the whole body, as described.(21)
Park S.L., Li Y., Sheng X., Hom V., Xia L., Zhao K., Pooler L., Setiawan V.W., Lim U., Monroe K.R., Wilkens L.R., Kristal B.S., Lampe J.W., Hullar M., Shepherd J., Loo L.L., Ernst T., Franke A.A., Tiirikainen M., Haiman C.A., Stram D.O., Le Marchand L, & Cheng I. (2020). Genome‐Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study. Hepatology Communications, 4(8), 1112-1123.
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5

Resting-state fMRI acquisition protocol

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Data were acquired using five 3T Siemens TIM Trio scanners and one 3T GE MR750 scanner using an AC-PC aligned echo-planar imaging pulse sequence (TR/TE 2 s/30 ms, flip angle 77°, 32 slices collected sequentially from superior to inferior, 3.4 × 3.4 × 4 mm with mm gap, 162 frames, 5:24 mins) to obtain T2*-weighted images. Subjects were instructed to lie in the scanner with eyes closed.
Hare S.M., Law A.S., Ford J.M., Mathalon D.H., Ahmadi A., Damaraju E., Bustillo J., Belger A., Lee H.J., Mueller B.A., Lim K.O., Brown G.G., Preda A., van Erp T.G., Potkin S.G., Calhoun V.D, & Turner J.A. (2018). Disrupted Network Cross Talk, Hippocampal Dysfunction and Hallucinations in Schizophrenia. Schizophrenia research, 199, 226-234.
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