PLGA polymer with a lactide/glycolide ratio of 50:50 and a molecular weight 38,000–54,000 kDa (Resomer® 504, Evonik, Darmstadt, Germany), polyvinyl alcohol (PVA), sodium lauryl sulfate (SLS), dimethyl sulfoxide (DMSO), and phosphate-buffered saline (PBS) tablets were purchased from Sigma-Aldrich (St Louis, MO, USA). Sodium hyaluronate of microbial origin (molecular weight 1,500–2,500 kDa) was purchased from Humedix (Sungnam, South Korea). Eudragit RL (a copolymer of ethyl acrylate, methyl methacrylate, and a low content of methacrylic acid ester with quaternary ammonium groups) was kindly provided by Evonik. The fluorescent probe 1,1′-dioctadecyl-3,3,3′,3′ tetramethylindotricarbocyanine iodide (DiR) was purchased from Marker Gene Technologies, Inc. (Eugene, OR, USA). Ethyl acetate and dichloromethane were purchased from Samchun Pure Chemical (Kyunggi-do, South Korea). Acetonitrile and methanol were obtained from J.T. Baker (Phillipsburg, NJ, USA). All other chemicals used were of the highest commercial grade available.
Eudragit rl
Manufactured by Evonik
Sourced in Germany
Eudragit RL is a polymeric material used in pharmaceutical applications. It is a copolymer of ethyl acrylate, methyl methacrylate, and a low content of methacrylic acid ester with quaternary ammonium groups. This material is designed for use in controlled-release drug formulations.
Automatically generated - may contain errors
Lab products found in correlation
Eudragit rs, by Evonik (2 mentions)
Methanol, by Avantor (1 mentions)
Sodium lauryl sulfate, by Merck Group (1 mentions)
Acetonitrile, by Avantor (1 mentions)
Ethyl acetate, by Samchun (1 mentions)
Dichloromethane, by Samchun (1 mentions)
Nicotine ditartrate dihydrate, by Thermo Fisher Scientific (1 mentions)
Vivapur ph101, by JRS Pharma (1 mentions)
Peg400, by Merck Group (1 mentions)
Paracetamol usp grade, by Merck Group (1 mentions)
Eudragit l100 55, by Evonik (1 mentions)
6 protocols using eudragit rl
1
PLGA-Based Nanoparticle Formulation Development
2
Nicotine-loaded Cationic Nanocapsules
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The nanocapsules were produced by the interfacial deposition of the pre-formed polymer method [3 (link)]. Initially, an emulsion was prepared by mixing an organic phase to an aqueous phase. The aqueous phase contained 26 mL of distilled water and 0.038 g of the detergent Triton X-100. The organic phase was prepared with 0.05 g of the cationic polymer (Eudragit® RL, Evonik, São Paulo, SP, Brazil), 15 mg of nicotine ditartrate dihydrate (Acros Organics®, São Paulo, Brazil) 0.082 g of castor oil and 13.5 mL of acetone. Upon homogenization of the phases, the organic phase was poured into the aqueous phase, under vigorous magnetic stirring for 10 min. Following this, the excess solvent and water were evaporated in a rotary evaporator at 30 mbar and 40 °C bath heating in order to adjust the concentration of nicotine and reach the final volume of 5 mL of suspension.
Empty nanocapsule suspensions were prepared by the same method, without adding nicotine to the formula.
Empty nanocapsule suspensions were prepared by the same method, without adding nicotine to the formula.
3
Development and Evaluation of Controlled-Release Formulations
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DS and DP were kindly supplied by TABUK Pharmaceuticals (Tabuk, Saudi Arabia). Eudragit RL PO and Eudragit RS PO were obtained from Evonik (Germany). Granulac 200® (lactose monohydrate) was kindly supplied by Meggle Pharma (Wassenberg, Germany). Vivapur® PH 101 (microcrystalline cellulose or MCC) was purchased from JRS Pharma (Weissenborn, Germany). All other chemicals were of pharmaceutical grade.
4
Preparation and Characterization of S-8-Loaded Hydroxyapatite Tablets
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The SRM was prepared by dissolving polyethylene glycol (PEG-400, Sigma-Aldrich, Belgium), ammonio methacrylate copolymer type A NF (Eudragit® RL, Evonik Röhm GmbH, Germany), and S-8 (Daren Labs, Israel) in absolute ethanol (J. T. Baker, USA) until a homogenous solution was obtained [27 (link)]. The concentration of S-8 in the SRM was 20% of the dry weight. In order to determine the direct effect of SRM-S-8, one side of 9.5 mm diameter hydroxyapatite (HA) tablets (Clarkson Chromatography Products Inc., South Williamsport, PA, USA) was coated with the SRM preparation. The coated HA tablets were left to dry overnight at room temperature (RT). The tablets were weighed before and after coating, and the amount of S-8 was calculated as its weight percentage of the SRM-S-8.
5
Paracetamol Polymer-Based Formulation
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Paracetamol USP grade (Sigma-Aldrich, UK) was used as a model drug (MW 151.16, solubility at 37ºC: 21.80 g/L. Eudragit L100-55, a copolymer of methacrylic acid and ethyl acrylate (1:1 ratio) that dissolves at pH 5.5 and above and Eudragit RL (copolymer of ethyl acrylate, methyl methacrylate and a low content of methacrylic acid ester with quaternary ammonium groups: the ammonium groups present as salts making the polymer permeable) were kindly donated by Evonik, Germany. Ethyl cellulose N7 (ethoxyl-grade N, ethoxyl content 48.0-49.5%, viscosity 5.6-8 mPas) was kindly donated by Hercules, US.
Polyethylene oxide (PEO 1,000,000 MW; PEO 1M) (WSR N-12K LEO NF) was kindly donated by Colorcon, UK. Candurin ® Gold Sheen was purchased from Azelis, UK. The salts for preparing the buffer dissolution media were purchased from VWR International Ltd., UK.
Polyethylene oxide (PEO 1,000,000 MW; PEO 1M) (WSR N-12K LEO NF) was kindly donated by Colorcon, UK. Candurin ® Gold Sheen was purchased from Azelis, UK. The salts for preparing the buffer dissolution media were purchased from VWR International Ltd., UK.
6
Sustained-Release Eudragit Coatings for Vancomycin Delivery
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Eudragit RS and Eudragit RL (Evonik Degussa Corporation, Germany), as sustained release control agents, are copolymers derived from esters of acrylic and methacrylic acid usually used for sustained release coating of pharmaceutical dosage forms. Triethyl citrate (TEC), as a liquid plasticizer, was purchased from Caledon Laboratories Ltd. (Ontario, Canada). Talc was purchased from Mallinickrodt Baker Inc (Canada). Vancomycin were provided (Zhejiang Medicine Co, Ltd Xinchang Pharmaceutical factory, China) as antibiotics.
Particle size reduction of Eudragit RL, Eudragit RS, talc and vancomycin were conducted separately by a jet mill, prior to use. Particle size of the powder was confirmed by a Particle Size Distribution Analyzer (TSI Corporation, Model 3603, Shoreview, MN, USA). The particle size at 50% of total weight fraction was used as average particle size. The average particle size of Eudragit RL, Eudragit RS, talc and vancomycin was 18.4 µm, 16.5 µm, 28.9 µm, and 29.0 µm respectively.
Particle size reduction of Eudragit RL, Eudragit RS, talc and vancomycin were conducted separately by a jet mill, prior to use. Particle size of the powder was confirmed by a Particle Size Distribution Analyzer (TSI Corporation, Model 3603, Shoreview, MN, USA). The particle size at 50% of total weight fraction was used as average particle size. The average particle size of Eudragit RL, Eudragit RS, talc and vancomycin was 18.4 µm, 16.5 µm, 28.9 µm, and 29.0 µm respectively.
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