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Aquarius workstation

Manufactured by TeraRecon
Sourced in United States

The Aquarius Workstation is a medical imaging software platform designed for advanced visualization and analysis of medical scans, including CT, MRI, and PET images. The Aquarius Workstation provides tools for segmentation, measurement, and advanced rendering of 3D images.

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25 protocols using aquarius workstation

1

Quantifying Epicardial Adipose Tissue Volume

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EAT volume was independently measured by 1 operator with a quantitative semi-automated procedure using a postprocessing workstation—TeraRecon Aquarius Workstation (version 4.4.7, TeraRecon, Inc., San Mateo, CA, USA). We used a simplified method previously validated, performing a single slice measurement of EAT at the level of the left main coronary artery. This kind of evaluation proved to be an efficient and clinically practical measure, acting as a surrogate for total epicardial fat volume with prognostic relevance.19 (link),20 (link)Before imaging, metoprolol may have been used for heart rate control. The scans were performed using a 64-slice TOSHIBA Aquilion CXL CT scan.
A non-contrast-enhanced, prospective ECG-triggered image acquisition (collimation 3.0 mm × 4 mm; gantry rotation 1⁄2 250 ms; tube current 200 mA; tube voltage 120 kV) was performed at the 75% phase, and images were reconstructed using a slice thickness of 3 mm. We manually traced the pericardial outline at the level of the ostium of the left main coronary artery. The volume of tissue within the outlined boundary (ROI) with an attenuation of −250 to −30 HU was calculated (cm3). This process was repeated for each patient/CT (Figure 1). The same acquisitions were used for CAC score quantification using the Agatson score algorithm.
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2

Quantifying Sarcopenia in CT Imaging

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Contrast-enhanced abdominal CT scan was performed as routine staging work-up. One axial portal-phase image at the level of L3 was analyzed by a radiologist using commercial imaging software (TeraRecon Aquarius Workstation, TeraRecon, Foster City, CA, USA). According to the different Hounsfield units radiodensities of different tissue types, the software automatically calculates the skeletal muscle area (−29 to +150), abdominal fat area (−50 to −150), and subcutaneous fat area (−190 to −30) (Figs. 1 and 2) [14 (link)]. The SMI was calculated by dividing the muscle area (m2) by the square of the patient's height (cm2). Sarcopenia was defined as an SMI <41 cm2/m2 in women and <43 cm2/m2 in men with a body mass index (BMI) <25 kg/m2, and <53 cm2/m2 in men with a BMI >25 kg/m2 [15 (link)].
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3

Measuring Body Composition Changes

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Total body fat area, visceral fat area (VFA), and subcutaneous fat area (SFA) were measured automatically on the selected axial image at the umbilical level using the TeraRecon Aquarius Workstation (TeraRecon, Foster City, CA, USA). The skeletal muscle area was measured at the level of the third lumbar vertebral body transverse processes using the same workstation. The skin, visceral organs, and central spinal canal were excluded manually in the selected axial image to identify specific measurement areas. The abdominal wall and back muscle areas (psoas, paraspinal, transversus abdominis, rectus abdominis, internal oblique, and external oblique) were calculated using the area of pixels with attenuation between −29 and 150 Hounsfield units in demarcated areas. All measurements were performed by an abdominal radiologist (L.E.S.; 10-year experience) (Fig. 1). Thereafter, the differences in skeletal muscle mass and abdominal fat before and 1 year after surgery were calculated and compared.
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4

Quantifying Perivascular Fat Attenuation

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To measure the perivascular pFAI, we used a software package (Aquarius Workstation version 4.4.13; TeraRecon Inc., Foster City, CA), and we traced proximal 40‐mm segments of the 3 major epicardial coronary vessels (for right coronary artery starting 10 mm distal to the ostium, while for left anterior descending artery and circumflex artery starting normally at the ostium)5 and defined perivascular fat as the adipose tissue within a radial distance from the outer vessel wall equal to the diameter of the vessel. We ascertained the perivascular fat attenuation index by quantifying the weighted perivascular fat attenuation after adjustment for technical parameters (if 100‐kV voltage was used instead of 120‐kV voltage, the mean Hounsfield unit [HU] value was corrected dividing by 1.11485) on the basis of the attenuation histogram of perivascular fat within the range −190 to −30 HU, as described previously5 (see Data S1 for details on pFAI measurement).
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5

Multidetector CTA Assessment of IPA Anatomy

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All multidetector CTA data was transferred from the archive to a workstation (Aquarius workstation; TeraRecon, San Mateo, CA, USA), via internal network connections, providing three-dimensional post-processing options, and multi-planar image reformatting and maximum intensity projections. All examinations were reviewed by two radiologists (a final-year radiology resident and a radiologist with 8 years of experience) independently with respect to the anatomy of the IPA and celiac axis. In cases of discrepancy, the CTA images were reviewed again to reach a consensus on all variations. The origin of the IPA was assessed and classified in order to describe the results of analyses.
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6

Coronary Artery Calcium Scoring Protocol

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All CT scans were performed using a 64-slice scanner system (Lightspeed, GE Healthcare, Waukesha, WI, USA) and a 40-slice scanner system (Brilliance 40, Philips, Hamburg, Germany). Tube voltage was 120 kVp and tube current was 125 mA. Step and shoot mode was used with prospectively ECG triggered to 75% of the R-R interval in subjects with a heart rate (HR) at most 65 beats per minute (bpm) and 45% of the R-R interval in subjects with a HR faster than 65 bpm. Imaging was reconstructed into a 2.5-mm slice thickness with a 512 X 512 matrix and a 25-cm field-of-view. No premedication with nitrate or beta-blocker was administered. CAC score analysis was performed using dedicated software (Terarecon Aquarius Workstation, San Mateo, California, USA) and CAC scores were subsequently calculated using the methods described by Agatston et al..[17 (link)] Then, subjects were classified into four groups according to CAC score as follows: 0, 1–99, 100–399 and ≥ 400.[3 (link),18 (link)]
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7

Quantifying Epicardial Adipose Tissue

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CT imaging was performed using dual source computed tomography (Siemens Somatom Definition Flash or Somatom Force, Siemens, Forchheim, Germany). A non-contrast enhanced CT-scan for the assessment of coronary artery calcification, prospectively triggered at 70% of the RR-interval with 3mm slice thickness, was followed by CT angiography. Since the present data are based on a retrospective analysis, scan parameters differed based on scanner type and patient characteristics. CT examinations were performed using prospective triggering in most cases. Tube voltage was adjusted based on patients habitus.
From non-contrast CT images, EAT volume and attenuation were quantified offline using a dedicated workstation (Aquarius Workstation, TeraRecon, Foster City, CA, USA) as previously described.[5 (link)] In brief, EAT volume was assessed for all patients by manual tracing of the pericardial sac as outer border in axial planes from the right pulmonary artery to the apex of the heart. Within the region of interest, fat was defined as pixels within a window of -195 to -45 HU and a window center of -120 HU.[12 (link)] After 3-dimensional reconstruction, fat volume was automatically calculated by the software program. EAT attenuation was calculated as mean Houndsfield units of all pixels, which were counted as EAT volume. All EAT measures were performed by a single reader.
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8

Coronary Calcium Evaluation via 320-Detector CT

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Image acquisition for coronary calcium evaluation was performed using a 320-detector CT system (Aquilion One ViSION, Toshiba Medical System, Japan), with cardiac synchronization using prospective triggering with a maximum temporal resolution of 125–250 ms as referenced in the literature31 (link). The produced slice thickness of 0.5 mm was reconstructed to a 3 mm slice thickness for analysis, X-ray tube peak voltage was fixed at 120 kV, and the tube current was adjusted to the patient's body size, with a range of 250–450 mA. The adaptive iterative dose reduction 3-dimensional algorithm (AIDR 3D) was used for iterative reconstruction32 (link), resulting in a radiation dose ranging from 2.6 to 4.0 mSv. CAC values were calculated using the Agatston score9 (link) at a dedicated workstation (Aquarius workstation, TeraRecon, Inc, San Mateo, CA). The nonenhanced scan protocol was used to analyze the calcium score evaluation. The images were evaluated by one specialist medical doctor with at least 2 years of specific training who was unaware of the patient’s clinical and tomographic information.
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9

Coronary Artery Calcium Scoring

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For reference CAC score determination, non-enhanced chest CT images were analyzed for the presence and extent of CAC according to the Agatston method (11 (link)) using dedicated software (Aquarius Workstation, TeraRecon, Inc., San Mateo, CA, USA) by two experienced radiology technologists with at least seven years of experience in CAC scoring. The software overlays CAC lesions having more than 130 Hounsfield units with colors, and the observers manually labeled the CAC lesions according to their anatomical locations (i.e., left main [LM], left anterior descending artery [LAD], left circumflex artery [LCx], and right coronary artery [RCA]) by visually confirming each CAC lesion.
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10

Coronary Artery Calcium Quantification

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CAC was assessed by computed tomography (CT) at the year 20 and 25 visits. Electron beam CT (Imatron C-150) or multidetector CT scanners (GE Lightspeed or Siemens VZ/Siemens Biograph 16) were used to obtain consecutive 2.5 -3mm-thick transverse images from the root of the aorta to the apex of the heart in two sequential electrocardiogram-gated scans.14 (link) Experienced image analysts measured calcified plaques in the epicardial coronary arteries (left main, left circumflex, left anterior descending, and right) at a central reading center (Wake Forest University Health Sciences, Winston Salem, NC). A total calcium score, using a modified Agatston method to account for slice thickness, was calculated on an FDA-approved workstation (TeraRecon Aquarius Workstation, San Mateo, CA) for each of the two sequential scans and averaged.15 (link) At year 20, two sequential scans were obtained and their scores averaged; at year 25 a single scan was used based on the reproducibility of prior studies and to reduce radiation exposure. Review and adjudication by an expert physician in cardiovascular imaging was performed for all participants with discordant scan pairs (year 20 examination), a change in calcium status from the previous CAC evaluation, evidence of possible surgical intervention, concerns identified by the reader, or calcium scores >200.
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