Kollidon va64 va64

We purchased micronized griseofulvin (BP/EP grade, BCS Class II, GF) from Letco Medical (Decatur, AL, USA). The aqueous solubility of GF is 14.2 mg/L at 37 °C [40 (link)]. Its melting point T_m and glass transition temperature T_g are 220 °C and 89 °C, respectively [41 (link)]. Three polymers and one surfactant were used in the formulations. BASF (Tarrytown, NY) donated Soluplus^® (Sol), which is a graft copolymer made of polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol, and its T_g is 73 °C [42 (link)]. Kollidon VA64 (VA64) was also donated by BASF, which is a vinylpyrrolidone-vinyl acetate copolymer with a T_g of 102 °C [43 ]. Dow Chemicals (Midland, MI, USA) donated hydroxypropyl methyl cellulose (HPMC, Methocel-E3 grade), which is a nonionic cellulosic polymer with a T_g of 174 °C [44 (link)]. We purchased sodium dodecyl sulfate (ACS grade, SDS) from GFS chemicals (Columbus, OH, USA), which is an anionic surfactant used to enhance the wettability of the ASD particles in the dissolution tests. We purchased acetone (ACS reagent, ≥99.5%) and ethanol (reagent alcohol, ≥95%) from BDH Analytical chemicals (Radnor, PA, USA) and used them as solvents to prepare drug–polymer solutions. We purchased the milling media, yttrium zirconia beads (Zirmil Y), from Saint Gobain ZirPro (Mountainside, NJ, USA), which had a median size of 430 μm.