All reagents were purchased at high commercial quality and used without further purification.
Transfer gas helium 5.0 and target gas nitrogen/0.05% oxygen mixture for 11 C-radionuclide production were purchased from AGA (Sweden). Disposable reaction vials (crimp neck, conical 0.9 mL) were purchased from VWR (Sweden) and capping septum (1.5 mm, 11 mm aluminium crimp cap, silicone/PTFE seal) was purchased from Scantec Nordic (Sweden). All presented radiochemical yields are decay corrected. The synthesis was automated using Tracer Production System (TPS) built in-house. Purification was performed by semi-preparative high-performance liquid chromatography (VWR LaPrep) equipped with pump (LP-1200), UV detector (Detector 40D), radiodetector (Flow-Count PMT, Bioscan), auto-sampler (TPS, built in-house) and a column. The effluent was monitored using UV detector (254 nm) and radiodetector. The radiochemical purity and identities of the labelled products were assessed by analytical HPLC (VWR LaChrom Elite) equipped with an auto-sampler (L-2200), pump (L-2130), diode array detector (L-2450), radiodetector (Flow-Count PMT, Bioscan).
Transfer gas helium 5.0 and target gas nitrogen/0.05% oxygen mixture for 11 C-radionuclide production were purchased from AGA (Sweden). Disposable reaction vials (crimp neck, conical 0.9 mL) were purchased from VWR (Sweden) and capping septum (1.5 mm, 11 mm aluminium crimp cap, silicone/PTFE seal) was purchased from Scantec Nordic (Sweden). All presented radiochemical yields are decay corrected. The synthesis was automated using Tracer Production System (TPS) built in-house. Purification was performed by semi-preparative high-performance liquid chromatography (VWR LaPrep) equipped with pump (LP-1200), UV detector (Detector 40D), radiodetector (Flow-Count PMT, Bioscan), auto-sampler (TPS, built in-house) and a column. The effluent was monitored using UV detector (254 nm) and radiodetector. The radiochemical purity and identities of the labelled products were assessed by analytical HPLC (VWR LaChrom Elite) equipped with an auto-sampler (L-2200), pump (L-2130), diode array detector (L-2450), radiodetector (Flow-Count PMT, Bioscan).