Magnetom allegra 3t mri

Manufactured by Siemens

Sourced in Germany

The Magnetom Allegra 3T MRI is a magnetic resonance imaging (MRI) system designed for clinical and research applications. It features a 3 Tesla (3T) superconducting magnet, which provides a strong and stable magnetic field for high-quality image acquisition. The Magnetom Allegra 3T MRI is capable of performing a variety of MRI examinations, including neuro, cardiac, and musculoskeletal imaging.

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5 protocols using magnetom allegra 3t mri

Multimodal 3T MRI Brain Imaging Protocol

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Neuroimaging procedures were completed using a head-only Magnetom Allegra 3T MRI at Washington University in St. Louis, MO (Siemens Healthcare, Erlangen, Germany). The 3T Allegra has powerful performance gradients with a maximum strength of 40 m/T/m in a 100 μs rise time and a slew rate of 400/T/m/s. Acquisition parameters were designed to maximize whole-brain coverage and signal-to-noise ratio (SNR), while minimizing artifact. Subject head movement was restrained through specialized foam pads and application of surgical tape across the forehead. Total scan time was less than one hour. Each scanning session began with the collection of a scout scan consisting of three orthogonal planes to confirm head positioning. The same scanner hardware and vendor operating software were used through the duration of the study to ensure quality control of the acquired data.
A T1-weighted magnetization-prepared rapid-acquisition gradient echo (MP-RAGE) sequence (Mugler and Brookeman 1990 (link)), double-echo proton-density (PD)/T2-weighted turbo spin echo (TSE) sequence, and a T2-weighted fluid-attenuated inversion-recovery (FLAIR) TSE sequence (Hajnal et al. 1992 ) were used to obtain whole-brain structural scans. Standard shimming was implemented to adjust for magnetic inhomogeneities.

Salminen L.E., Schofield P.R., Pierce K.D., Luo X., Zhao Y., Laidlaw D.H., Cabeen R.P., Conturo T.E., Lane E.M., Heaps J.M., Bolzenius J.D., Baker L.M., Cooley S.A., Scott S., Cagle L.M, & Paul R.H. (2015). Genetic markers of cholesterol transport and gray matter diffusion: A preliminary study of the CETP I405V polymorphism. Journal of neural transmission (Vienna, Austria : 1996), 122(11), 1581-1592.

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3T fMRI Brain Imaging Protocol

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Data were collected on a Siemens MAGNETOM Allegra 3T MRI head-only scanner. Head motion was constrained by the use of foam padding. All functional images were acquired with a T2*-weighted gradient echo planner pulse sequence covering the whole brain including the cerebellum with 32 axial slices (TR 2000 ms, TE 30 ms, FA 90°, FOV 224, slice thickness 4 mm, matrix size 64 × 64, flip angle 90°). Voxel size was 3.5 × 3.5 × 4 mm. A gradient echo image (TR 704 ms, TE 5.11 and 7.57 ms; flip angle 60°) with the same grid and slice orientation as the functional images was acquired to generate a field map for correcting susceptibility-related distortions in the functional images. A T1-weighted anatomical scan was also acquired (TR 2250 ms, TE 2.6 ms, flip angle 9°, FOV 256 mm, slice thickness 1 mm, matrix size 256 × 256, number of slices 192). Voxel size was 1 × 1 × 1 mm.

Stiers P, & Goulas A. (2018). Functional connectivity of task context representations in prefrontal nodes of the multiple demand network. Brain Structure & Function, 223(5), 2455-2473.

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Diffusion-Weighted MRI Protocol for Brain

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All participants were scanned at a single site using a head-only Magnetom Allegra 3T MRI (Siemens Medical Solutions, Erlangen, Germany) with a standard imaging protocol that included a diffusion-weighted MRI sequence. Head positioning was confirmed by a preliminary scout scan composed of three orthogonal planes collected from each individual at the beginning of the scanning procedure. Movement artefact was limited by application of surgical tape across the forehead to enhance stability. High-performance gradients (maximum strength 40 mT/m in a 100-ms rise time; maximum slew rate 400 T/m/s) were utilized to minimize scan times (< 1 hour). FSL BET was used to extract whole brain masks for each subject, and intracranial volume (ICV) was computed from the total volume inside the mask (Jenkinson, Beckmann, Behrens, Woolrich and Smith 2012 (link)).

Garcia-Egan P.M., Preston-Campbell R.N., Salminen L.E., Heaps-Woodruff J.M., Balla L., Cabeen R.P., Laidlaw D.H., Conturo T.E, & Paul R.H. (2019). Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults. Brain imaging and behavior, 13(6), 1602-1611.

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High-quality MRI Acquisition Protocol for Whole-brain Imaging

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Participants were scanned in a head-only Magnetom Allegra 3T MRI, located at Washington University in St. Louis, MO (Siemens Healthcare, Erlangen, Germany). The Allegra is a high performance scanner with maximum strength gradients of 40 m/T/m in a 100 μs rise time and a slew rate of 400/T/m/s. Acquisition parameters were designed for whole-brain coverage with a high signal-to-noise ratio (SNR) to minimize scanner artifact. Head movement was restrained through specialized foam pads and by placing surgical tape across the forehead. Total scan time was < 1 hour. Quality control was maintained through daily quality assurance tests to ensure consistent MRI performance across subjects. The same scanner and processing software were used for the duration of the study. Head positioning was confirmed through a scout scan consisting of three orthogonal planes that was collected from each participant at the beginning of the scanning session.
Whole-brain scans were acquired using a T1-weighted magnetization-prepared rapid-acquisition gradient echo (MP-RAGE) sequence [43 (link)], a double-echo proton-density (PD)/T2-weighted turbo spin echo (TSE)sequence, and a T2-weighted fluid-attenuated inversion-recovery (FLAIR) TSE sequence[44 (link)]. Standard shimming was applied to adjust for magnetic in homogeneities. A detailed description of this protocol can be found in Paul et al. [45 (link)].

Salminen L.E., Schofield P.R., Pierce K.D., Zhao Y., Luo X., Wang Y., Laidlaw D.H., Cabeen R.P., Conturo T.E., Tate D.F., Akbudak E., Lane E.M., Heaps J.M., Bolzenius J.D., Baker L.M., Cagle L.M, & Paul R.H. (2015). Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition. Behavioural brain research, 296, 85-93.

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Head MRI Acquisition Protocol

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Imaging acquisition took place using a head-only Magnetom Allegra 3T MRI scanning system (Siemens Medical Solutions, Erlangen, Germany) at Washington University - St. Louis. For quality assurance, identical pulse sequences and movement minimization tactics (e.g., tape across the forehead) were consistent throughout the course of the study. To ensure data reliability, daily quality control tests were performed, and stability was maximized by avoiding modifications to scanning software and equipment. This scanner has high-performance gradients (max strength 40 mT/m in a 100-microsecond rise time on all three axes simultaneously; maximum slew rate 400 T/m/s on each axis), limiting the session time to one hour. Head placement was confirmed by a preliminary scout scan composed of three orthogonal planes.

Behrman-Lay A.M., Usher C., Conturo T.E., Correia S., Laidlaw D.H., Lane E.M., Bolzenius J., Heaps J.M., Salminen L.E., Baker L.M., Cabeen R., Akbudak E., Luo X., Yan P, & Paul R.H. (2015). Fiber bundle length and cognition: A length-based tractography MRI study. Brain imaging and behavior, 9(4), 765-775.

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