All melting points were measured on a Gallenkamp melting point apparatus. The infrared spectra were recorded in potassium bromide discs on a Pye Unicam SP 3–300 and Shimadzu FT IR 8101 PC infrared spectrophotometers. The NMR spectra were recorded in deuterated chloroform (CDCl3) or dimethyl sulfoxide (DMSO-d6). On a Varian Mercury VXR-300 NMR spectrometer. Chemical shifts were related to that of the solvent. Mass spectra were recorded on a Shimadzu GCMS-QP1000 EX mass spectrometer at 70 eV. Elemental analyses were recorded on a Elementar-Vario EL automatic analyzer at the Micro-analytical Centre of Cairo University, Giza, Egypt. Formamidine 3 is prepared according to our pervious reported work [39 (link)] (Scheme 6 ). The Microwave irradiation was carried out on a CEM mars machine. CEM has several vessel types that are designed for their ovens: Closed-system vessels including the HP-500 (500 psig material design pressure and 260 °C), pictured below, have liners are composed of PFA and are ideal for many types of samples. HP-500 Plus vessels are ideal for routine digestion applications. Process up to 14 high-pressure vessels per run with temperatures up to 260 °C or pressures up to 500 psi (Scheme 7 ).
Mercury vxr 300 nmr spectrometer
Manufactured by Agilent Technologies
The Mercury VXR-300 NMR spectrometer is a nuclear magnetic resonance instrument designed for analytical chemistry applications. It operates at a frequency of 300 MHz and is capable of detecting and analyzing the nuclear magnetic properties of various chemical compounds.
Automatically generated - may contain errors
Lab products found in correlation
Unicam sp 3 300, by Shimadzu (3 mentions)
Gcms qp1000 ex mass spectrometer, by Shimadzu (2 mentions)
Gcms qp 1000 ex mass spectrometer, by Elementar (1 mentions)
Ft ir 8101 pc infrared spectrophotometer, by Shimadzu (1 mentions)
Gcmqp 1000 ex spectrometer, by Shimadzu (1 mentions)
Vector 22 spectrophotometer, by Bruker (1 mentions)
F254 merck plates, by Merck Group (1 mentions)
1430 spectrophotometer, by PerkinElmer (1 mentions)
6 protocols using mercury vxr 300 nmr spectrometer
1
Microwave-Assisted Synthesis of Formamidine Derivatives
2
Synthesis and Characterization of Novel Heterocyclic Compounds
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Melting points were determined in open glass capillaries with a Gallenkamp apparatus. Elemental analyses were carried out at the Microanalytical Center of Cairo University, Giza, Egypt. The infrared spectra were recorded as potassium bromide disks on a Pye Unicam SP 3–300 and Shimadzu FTIR 8101 PC infrared spectrophotometer. NMR spectra were recorded on Varian Mercury VXR-300 NMR spectrometer at 300 MHz (1H NMR) and at 75 MHz (13C NMR) using DMSO-d6 as solvent Chemical shifts were reported downfield from TMS (= 0) for 1H NMR. For 13C NMR, chemical shifts were reported in the scale relative to the solvent used as an internal reference. Mass spectra (EI) were obtained at 70 eV with a type Shimadzu GCMQP 1000 EX spectrometer. The enaminone 3 , [55 (link)] hydrazonoyl chloride 4 , [56 ] aldehyde-thiosemicarbazones 7a-c , [57 , 58 (link)] acetyl-thiosemicarbazones 9, 10, 11 [59 (link), 60 (link)], bis-aldehydes 15a-c , 19a-c [61 (link)–63 (link)], and bis-thiosemicarbazones 17a-c , 20a-c , [64 (link)–67 (link)] were prepared following procedures reported in the literature.
3
Microwave-Assisted Organic Synthesis Protocols
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All melting points were measured on a Gallenkamp melting point apparatus. The infrared spectra were recorded in potassium bromide discs on a Pye Unicam SP 3–300 and Shimadzu FT IR 8101 PC infrared spectrophotometers. The NMR spectra were recorded in dimethyl sulfoxide (DMSO-d6) or CDCl3.on a Varian Mercury VXR-300 NMR spectrometer. Chemical shifts were related to that of the solvent. Mass spectra were recorded on a Shimadzu GCMS-QP1000 EX mass spectrometer at 70 eV. The Microwave irradiation was carried out on a CEM mars machine. CEM has several vessel types that are designed for their ovens: closed-system vessels including the HP-500 (500 psig material design pressure and 260 °C), have liners are composed of PFA and are ideal for many types of samples. HP-500 Plus vessels are ideal for routine digestion applications. Process up to 14 high-pressure vessels per run with temperatures up to 260 °C or pressures up to 500 psi.
4
Characterization of Novel Compounds
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Melting points were measured with using a Stuart melting point apparatus and were uncorrected. The IR spectra were recorded using an FTIR Bruker-vector 22 spectrophotometer as KBr pellets. The 1H and 13C NMR spectra were recorded in DMSO-d6 as a solvent with Varian Mercury VXR-300 NMR spectrometer operating at 300 MHz and 75 MHz, using TMS as an internal standard. Chemical shifts were reported as δ values in ppm. Mass spectra were recorded with a Shimadzu GCMS-QP-1000 EX mass spectrometer in EI (70 eV) model. The elemental analyses were performed at the Micro Analytical Centre, Cairo University.
5
Characterization of Newly Synthesized Compounds
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All the reagents and solvents reported in present study were purchased from Sigma-Aldrich (Bayouni Trading Co. Ltd., Al-Khobar, Saudi Arabia) with high grade of purity and used without any further puri cation. The progress of all reactions was examined using thin-layer chromatography (TLC) on silica gel pre-coated F254Merck plates (Darmstadt, Germany) and the spots were detected by exposure to UV light at 250 nm. All melting points are uncorrected and were recorded on open capillary tubes using a Gallenkamp melting point apparatus. The FTIR measurements of the reported compounds were recorded on Shimadzu model FT-IR-8400S spectrophotometer using potassium bromide disks. The ¹ H, 13 C -NMR spectra were run on a Varian MercuryVXR-300 NMR spectrometer (Palo Alto, CA) at 400 and 125 MHz in dimethyl sulfoxide-d 6. Chemical shifts were reported in ppm (δ) with reference to the internal standard TMS. Mass spectra were obtained at 70 eV on a shimadzu GCMS-QP 1000EX spectrometer. Elemental analyses (C, H, and N) of the synthesized compounds were realized on CE 440 Elemental Analyzer-Automatic Injector (Exeter Analytical, Inc., USA) at the Micro analytical Center of Cairo University. The physical data, elemental analysis, mass spectra, and IR spectra results of all the newly synthesized compounds are presented in Table 1.
6
Spectroscopic Characterization and Anticancer Evaluation of Heterocyclic Compounds
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Chemistry All melting points were determined on an Electrothermal (9100) apparatus and are uncorrected. The IR spectra were recorded as KBr pellets on a PerkinElmer, Inc. 1430 spectrophotometer. The NMR spectra were recorded with a Varian Mercury VXR-300 NMR spectrometer at 300 and 75 MHz ( 1 H-and 13 C-NMR spectra, respectively) using DMSO-d 6 as solvent and results are expressed as δ values. Mass spectra were taken on a Shimadzu GCMS-QP 1000 Ex mass spectrometer at 70 eV. Elemental analyses were carried out at the Microanalyses Center at Cairo University and were performed on Vario EL III Elemental CHNS analyzer. The X-ray crystallography was performed at Institute of Organic Chemistry of University of Zürich. Anticancer activity was performed at National Cancer Institute at Cairo University of Egypt.
The starting compounds 2a-d were prepared according to lit. 40) (link)
The starting compounds 2a-d were prepared according to lit. 40) (link)
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