Fenofibrate

Manufactured by LGC

Sourced in Canada

Fenofibrate is a laboratory compound used in research and development. It is a pharmaceutical agent that belongs to the class of fibric acid derivatives. Fenofibrate is primarily used as a reference standard or for the development and validation of analytical methods in the pharmaceutical industry.

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Lab products found in correlation

2 protocols using fenofibrate

Structurally Diverse Glass Former Dataset

Cited 2 times

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A structurally diverse dataset (n = 26), composed of compounds previously classified as glass formers (GFs) when prepared by melt-quenching, solvent evaporation, or spray-drying methods, was included in the study [5 (link),7 (link),8 (link),9 (link),10 (link),18 (link)]. Only compounds supplied in their free crystalline form (i.e., no salts, solvates, hydrates, etc.), as confirmed by DSC analysis, were used.
Metolazone was purchased from API Chemical (Hangzhou, China). Acetaminophen, bezafibrate, clofoctol, chlorpropamide, dimethyl sulfoxide, glibenclamide, glipizide, hydrocortisone, sodium hydroxide, sodium phosphate, sodium chloride, sulfamerazine, sulfathiazole, and tinidazole were supplied by Sigma-Aldrich (Steinheim, Germany). Aripiprazole, cinnarizine, clotrimazole, droperidol, d-salicin, fenofibrate, flurbiprofen, hydrochlorothiazide, ibuprofen, ketoconazole, ketoprofen, prednisone, and probucol were obtained from Toronto Research Chemical (Toronto, ON, Canada). Indapamide and procaine were purchased from Tokyo Chemical Co. Ltd. (Tokyo, Japan). Acetone was supplied by Merck (Darmstadt, Germany), ethanol by Solveco (Rosersberg, Sweden), and phosphorus pentoxide by VWR (Leuven, Belgium). All of the chemicals used in this study were of either pharmaceutical or analytical grade with a specified purity of ≥ 97%.

Edueng K., Bergström C.A., Gråsjö J, & Mahlin D. (2019). Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physicochemical Properties. Pharmaceutics, 11(9), 425.

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Preparation of Lipid-Modulating Compounds

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EPA, DHA, vitamin E (α-tocopherol), fenofibrate, nicotinic acid (niacin), and gemfibrozil were purchased from Sigma-Aldrich (St Louis, MO). EPA and DHA were solubilized in ethanol to 1 mM under nitrogen atmosphere. Immediately before experimental use, vitamin E was prepared in ethanol at 1.0 mM (ε = 3.06 × 10⁴ M⁻¹·cm⁻¹ at 294 nm). Atorvastatin ortho- (o-) hydroxy (active) metabolite (atorvastatin metabolite) was purchased from Toronto Research Chemicals (North York, Ontario, Canada) and solubilized in methanol to 1.0 mM. fenofibrate, niacin, and gemfibrozil were solubilized in ethanol to 1.0 mM. All test compounds were further diluted in ethanol or aqueous buffer as needed.

Mason R.P., Sherratt S.C, & Jacob R.F. (2016). Eicosapentaenoic Acid Inhibits Oxidation of ApoB-containing Lipoprotein Particles of Different Size In Vitro When Administered Alone or in Combination With Atorvastatin Active Metabolite Compared With Other Triglyceride-lowering Agents. Journal of Cardiovascular Pharmacology, 68(1), 33-40.

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