Maprotiline hydrochloride

Manufactured by Merck Group

Sourced in United States

Maprotiline hydrochloride is a chemical compound used as a reference standard in analytical and research applications. It is a white crystalline powder that is soluble in water and organic solvents. Maprotiline hydrochloride is commonly used as a reference material for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) and gas chromatography (GC), for the identification and quantification of this compound in various samples.

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3 protocols using maprotiline hydrochloride

Electrochemical Sensor Development for Analyte Detection

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All chemicals and reagents were of the analytical grade and double distilled deionized water was used throughout experiments.
Graphite flakes (Timrex KS 44) were purchased from Imerys Graphite & Carbon (Bodio, Switzerland). Dibutylphthalate (DBP), phosphotungstic acid hydrate (PTA), maprotiline hydrochloride, and THP were purchased from Sigma (USA). Sodium tetraphenylborate (NaTPB), zinc nitrate hexahydrate, magnesium nitrate hexahydrate, acetylsalicylic acid, glucose, galactose, and fructose were purchased from Merck (Germany). Paracetamol was kindly provided by Galenic laboratory Split—Dalmatia County Pharmcy (Croatia). Sodium acetate anhydrous was purchased from Gram-mol (Croatia); glacial acetic acid, potassium nitrate, calcium nitrate tetrahydrate, iron (III) nitrate nonahydrate, and lead(II) nitrate from Kemika (Croatia); silver nitrate and ammonium chloride from Sigma-Aldrich (Germany). Parkopan (2 mg/tablet) used in the application of the prepared electrode was obtained from the local drugstore.

Radić J., Buljac M., Genorio B., Gričar E, & Kolar M. (2021). A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices. Sensors (Basel, Switzerland), 21(9), 2955.

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Screening of Approved Drugs for Neuroprotection

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Reagents were obtained from the following sources: adenosine 5’-triphosphate disodium salt (ATP), 2’(3’)-O-(4-Benzoylbenzoyl)adenosine 5’-triphosphate triethylammonium salt (BzATP), adenosine 5'-diphosphate sodium salt (ADP), amitriptyline hydrochloride, bupropion hydrochloride, clomipramine hydrobromide, maprotiline hydrochloride, mirtazapine, ivermectin, 4-Chloro-DL-phenylalanine methyl ester hydrochloride (PCPA), and N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) from Sigma-Aldrich (St. Louis, MO, USA); Fura-2-AM from Dojindo (Kumamoto, Japan); duloxetine hydrochloride and paroxetine hydrochloride from Toronto Research Chemicals (Toronto, Canada); pyridoxal phosphate-6-azophenyl-2’,4’-disulphonic acid (PPADS) tetrasodium salt from Tocris Bioscience (Bristol, UK). The approved drugs library of 1979 compounds were provided in the form of 96-well plate format by Drug Discovery Initiative, DDI, The University of Tokyo (Tokyo, Japan).

Yamashita T., Yamamoto S., Zhang J., Kometani M., Tomiyama D., Kohno K., Tozaki-Saitoh H., Inoue K, & Tsuda M. (2016). Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury. PLoS ONE, 11(10), e0165189.

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Detailed Chemical Characterization Protocol

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Bupivacaine hydrochloride (99%), haloperidol (>98%), lidocaine (>98%), maprotiline hydrochloride (>99%), mifepristone (>98%), and cyproheptadine hydrochloride (99%) were obtained from Sigma-Aldrich (St. Louis, MO, USA).
The following chemicals were used to prepare buffer solutions: acetic acid (>99%), formic acid (98%), and ethylenediamine (>98.8) from J. T. Baker (Center Valley, PA, USA), ammonia solution (25%) and trifluoroacetic acid (>99%) from Merck (Darmstadt, Germany), and ammonium bicarbonate (>99%) from Fluka (Buchs, Switzerland). To reach the desired pH value, 1 M sodium hydroxide or hydrochloric acid were added. The ionic strength of all buffer solutions was fixed to 0.1 M. These reagents were used for pK a determination: dimethyl sulfoxide >99.9% (DMSO), potassium dihydrogen phosphate (>99.5%), 0.5 M potassium hydroxide Titrisol  and 0.5 M hydrochloric acid Titrisol  from Merck. Potassium chloride >99% was from Sigma.
For HPLC quantification, formic acid, sodium formate (>99%, Fluka), and methanol (HPLC gradient grade) from Fisher Scientific (Loughborough, UK) were used.
Water was purified by a Milli-Q plus system from Millipore (Bedford, MA, USA), with a resistivity of 18.2 MΩ cm.

Fuguet E., Subirats X., Ràfols C., Bosch E, & Avdeef A. (2021). Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS). Molecular pharmaceutics, 18(6).

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