5 hydroxyflavone

Manufactured by Merck Group

Sourced in Germany

5-hydroxyflavone is a chemical compound used as a laboratory reagent. It is a flavonoid derivative with the chemical formula C₁₅H₁₀O₃. 5-hydroxyflavone serves as a precursor and building block for various organic synthesis reactions and assays. Its core function is to facilitate chemical transformations and analyses in controlled laboratory settings.

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Lab products found in correlation

3 protocols using 5 hydroxyflavone

Lanthanide-Labeled Protein Binding

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All reagents and solvents were of analytical reagent grade and were used without further purification. 5-hydroxyflavone, SmCl₃·6H₂O, EuCl₃·6H₂O, GdCl₃·6H₂O and TbCl₃·6H₂O, human transferrin and human serum albumin and double-stranded calf-thymus DNA were purchased from Sigma Aldrich Chemical Co. (Schnelldorf, Germany). All other chemicals and solvents were commercially available, and used without further purification.

Munteanu A.C., Badea M., Olar R., Silvestro L., Dulea C., Negut C.D, & Uivarosi V. (2016). Synthesis and Structural Investigation of New Bio-Relevant Complexes of Lanthanides with 5-Hydroxyflavone: DNA Binding and Protein Interaction Studies. Molecules, 21(12), 1737.

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Flavonoids Modulate rhsTRAIL Activity

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Soluble recombinant human TRAIL (rhsTRAIL) was purchased from PeproTech Inc. (Rocky Hill, NJ, USA). DMSO (dimethylsulfoxide), DMF (dimethylformamide) and Triton X-100 were obtained from Sigma Chemical Company (St. Louis, MO, USA). 5-Hydroxyflavone, 6-methoxyflavone, 6-Hydroxyflavone, 7-methoxyflavone and 7-Hydroxyflavone were purchased from Sigma Chemical Company. 6-Hydroxyflavone and 7-Hydroxyflavone were obtained by biotransformation of 6-methoxyflavone, 7-methoxyflavone, 6-Hydroxyflavone and 7-Hydroxyflavone. The flavones were dissolved in DMSO (≤50 mM) or in DMF (50 mM) to a final concentration of 0.1% (v/v) in culture media.

Bronikowska J., Szliszka E., Kostrzewa-Susłow E., Jaworska D., Czuba Z.P., Bednarski P, & Król W. (2017). Novel Structurally Related Flavones Augment Cell Death Induced by rhsTRAIL. International Journal of Molecular Sciences, 18(6), 1211.

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Characterization of Polyphenol Compounds

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All chemical reagents were purchased from commercial suppliers and used without further purification. epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), pyrogallol (Pyro), gallic acid (GA), 3-hydroxybenzoic acid (3-HBA), 3,4-hydroxybenzoic acid (3,4-HBA), 3,5-hydroxybenzoic acid (3,5-HBA), flavone (Fla), 5-hydroxyflavone (5-HF), 6-hydroxyflavone (6-HF), 7-hydroxyflavone (7-HF), naringenin (Nar), quercetin (Quer), myricetin (Myr), luteolin (Lut), baicalein (Baic), rosmarinic acid (RA), and resveratrol (Resv) were purchased from Sigma–Aldrich. 3-HBA, 3,4-HBA, and 3,5-HBA were prepared by dissolving the compound powder in water. All other compounds were dissolved in dimethyl sulfoxide (DMSO).

Lantz R., Busbee B., Wojcikiewicz E.P, & Du D. (2020). Flavonoids with Vicinal Hydroxyl Groups Inhibit Human Calcitonin Amyloid Formation. Chemistry (Weinheim an der Bergstrasse, Germany), 26(57), 13063-13071.

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