Vaginal applicator diameter ranged from 2.0 to 3.5 cm (median 3 cm). OncentraBrachy treatment planning system and MicroSelectron (Elekta, Stockholm, Sweden) device with a 192-Ir source were used to plan and treat the first cohort of patients (cohort 1–C1), respectively. The proximal third of the vagina was irradiated with a HDR-IRT schedule based on 21 Gy in three weekly fractions (7 Gy) prescribed 0.5 cm from the applicator surface. OncentraBrachy treatment planning system and a Flexitron (Elekta, Stockholm, Sweden) device with a 192-Ir source were used to treat the second cohort of patients (cohort 2 – C2). The upper 3 cm of the vagina was irradiated by a HDR-IRT schedule of 6 Gy per fraction/weekly (total dose 24 Gy) prescribed 0.5 cm from the applicator surface.
Lancellotta V., Macchia G., Dinapoli N., Autorino R., Campitelli M., Nardangeli A., Salvati A., Fionda B., Casà C., Cornacchione P., Rovirosa A., Kovács G., Morganti A.G., Ferrandina M.G., Gambacorta M.A, & Tagliaferri L. (2022). EROS 2.0 study: evaluation of two interventional radiotherapy (brachytherapy) schedules for endometrial cancer: a comparison of late vaginal toxicity rates. La Radiologia Medica, 127(3), 341-348.
+ Open protocol