1.2 dipalmitoyl sn glycero 3 phospho 1 rac glycerol sodium salt dppg

Manufactured by Avanti Polar Lipids

Sourced in United States

1.2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) (DPPG) is a synthetic phospholipid. It is a major component of bacterial and archaeal cellular membranes.

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Lab products found in correlation

Avanti mini extruder, by Avanti Polar Lipids (1 mentions) L α phosphatidylcholine, by Avanti Polar Lipids (1 mentions) Cholesterol ovine wool, by Avanti Polar Lipids (1 mentions) Cholesterol solution, by Merck Group (1 mentions) Mannitol, by Merck Group (1 mentions) 1 2 dioleoyl sn glycero 3 phosphocholine dopc, by Avanti Polar Lipids (1 mentions) 1 2 dipalmitoyl sn glycero 3 phosphocholine dppc, by Avanti Polar Lipids (1 mentions) Polyethylene glycol, by Merck Group (1 mentions) Milli q deionized water, by Merck Group (1 mentions) Milli q system, by Merck Group (1 mentions) Palmitic acid, by Merck Group (1 mentions)

3 protocols using 1.2 dipalmitoyl sn glycero 3 phospho 1 rac glycerol sodium salt dppg

Lipid-based Nanoparticle Formulation

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1.2-dipalmytoil-sn-glycero-3-phosphocholine (DPPC), cholesterol (ovine wool), L-α-phosphatidylcholine (Soy PC), 1.2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) (DPPG) and Avanti Mini-Extruder were purchased from Avanti Polar Lipids, Alabama. Histamine dihydrochloride, poly (ethylene glycol) (PEG, MW 8000), dextran (from Leuconostoc spp. MW 450000-600000) were obtained from Sigma-Aldrich, Sweden. Whatman nucleopore track-etched polycarbonate membranes, pore size 5 μm and Thermo Scientific Slide-A-Lyzer Dialysis Cassettes (10K MWCO) were purchased from Fisher Scientific, Sweden.

Lovrić J., Keighron J.D., Angerer T.B., Li X., Malmberg P., Fletcher J.S, & Ewing A.G. (2014). Analysis of liposome model systems by time-of-flight secondary ion mass spectrometry. Surface and interface analysis : SIA, 46(Suppl 1), 74-78.

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Liposome Formulation and Preparation

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Phospholipids 1,2- dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dioleoyl-sn-glycero- 3-phosphocholine (DOPC) and 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac- glycerol) (sodium salt) (DPPG) were purchased from Avanti Polar Lipids, Inc. (Alabaster, Alabama). A 10 mg/ml cholesterol solution and mannitol was purchased from Sigma Aldrich (St. Louis, Missouri). DPPC, DOPC, DPPG and cholesterol were mixed in the molar ratio 46:23:23:8 in a round bottom flask and placed in a rotary evaporator at 52 °C for 45–60 minutes (Eyela rotary evaporator, Tokyo Rikakikai Corporation Ltd., Product # N-1001, Bohemia, New York). The flask was placed in a vacuum desiccator for 3–4 hours to ensure complete removal of solvent.

Kandadai M.A., Meunier J.M., Hart K., Holland C.K, & Shaw G.J. (2014). Plasmin-loaded echogenic liposomes for ultrasound-mediated thrombolysis. Translational stroke research, 6(1), 78-87.

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Radiolabeled Lipid Nanoparticle Formulation

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Lipids of 1,2‐distearoyl‐sn‐glycero‐3‐phosphocholine (DSPC) and 1,2‐dipalmitoyl‐sn‐glycero‐3‐phospho‐(1′‐rac‐glycerol) (sodium salt) (DPPG) were purchased from Avanti Polar Lipids (Alabaster, AL, USA). Polyethylene glycol (MW: ∼4000, PEG), mannitol, palmitic acid, and perfluoroheptane were purchased from Sigma‐Aldrich (St. Louis, MO, USA). Sulfur hexafluoride and oxygen were purchased from Jietong Gas Technology (Guangzhou, China). ¹²⁵I seeds (Type 6711, diameter: 0.8 mm, length: 4.5 mm, matched peripheral dose: 100–140 Gy) were purchased from Yunke Pharmaceutical (Chengdu, China). All aqueous solutions were prepared in Milli‐Q deionized water (18 MΩ cm⁻¹, Millipore, MilliQ system).

Peng S., Song R., Lin Q., Zhang Y., Yang Y., Luo M., Zhong Z., Xu X., Lu L., Yao S, & Zhang F. (2021). A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy. Advanced Science, 8(7), 2002567.

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