The luteal phase was used routinely in all patients, starting from the day since IUI was performed. It consisted of Duphaston (Dydrogesterone Tablets, 20 mg/day, Abbott, Netherlands) for 14 days. A blood test for hCG assay was performed in 14 days after insemination to confirm whether pregnancy had occurred. In women with positive hCG, ultrasound examination was performed at 7 weeks’ gestation to confirm fetal viability. A clinical pregnancy was defined as one in which there was ultrasonographic evidence.
Dydrogesterone tablets
Manufactured by Abbott
Sourced in Netherlands
Dydrogesterone Tablets are a pharmaceutical product manufactured by Abbott. The product is a synthetic progestogen medication used in various medical applications. The core function of Dydrogesterone Tablets is to provide the active ingredient dydrogesterone, a hormone that plays a role in various physiological processes.
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Lab products found in correlation
4 protocols using dydrogesterone tablets
1
Luteal Phase Support for IUI Pregnancy
2
Personalized Ovarian Stimulation Protocol
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According to the patient's age, body mass index (BMI), basic sex hormone level, anti-Mullerian hormone (AMH) and antral follicle count (AFC), the appropriate stimulation protocol and starting dose were selected. Ovulation was triggered using 250 μg of recombinant hCG (Ovidrel, Merck-Serono, Switzerland) or 5000-10000 IU hCG (Lizhu, Zhuhai, China) when two follicles reached 18 mm or three follicles reached 17mm in diameter. Transvaginal ultrasound-guided oocyte retrieval was performed 34-36 hours later. Following oocyte retrieval, whether to carry out fresh ET or whole embryo freezing was determined according to whether the patient had high ovarian hyperstimulation syndrome (OHSS) risk, high progesterone level, uterine cavity and condition of endometrium. If fresh ET was planned, Progesterone Sustained-release vaginal gel (Crinone, Merck-Serono, Switzerland) 90mg/d or intramuscular progesterone 40mg/d was given on the day of oocyte retrieval. Dydrogesterone (DydrogesteroneTablets, Abbott biologicals, Netherlands) 10mg was orally administered twice a day until 14 days following embryo transfers.
3
Fresh and Frozen Embryo Transfers
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Embryo transfer was scheduled without inappropriate conditions for transplantation in the fresh cycle. In total, 1–2 embryos were transferred into the uterus by abdominal ultrasound on the 3rd or 5th day following oocyte retrieval. Dydrogesterone tablets (Duffton, Abbott, Weesp, The Netherlands) and progesterone sustained-release vaginal Gel (Crinone, Merck Serono, Switzerland) were used for corpus luteum support.
The patients who were at risk of ovarian hyperstimulation, higher progesterone levels on the day of HCG injection, or other conditions, such as fever, intra-abdominal cavity bleeding, and lack of pregnancy following fresh cycle transplantation, were subjected to frozen-thawed embryo transfer. In the frozen-thawed embryo transfer cycle, the endometrium was prepared by modified natural cycle or hormone replacement therapy as previously described.17 (link) Corpus luteum support with progesterone was continued until the 10th week of pregnancy.
The patients who were at risk of ovarian hyperstimulation, higher progesterone levels on the day of HCG injection, or other conditions, such as fever, intra-abdominal cavity bleeding, and lack of pregnancy following fresh cycle transplantation, were subjected to frozen-thawed embryo transfer. In the frozen-thawed embryo transfer cycle, the endometrium was prepared by modified natural cycle or hormone replacement therapy as previously described.17 (link) Corpus luteum support with progesterone was continued until the 10th week of pregnancy.
4
Luteal Phase Supplementation for IVF
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On the day of oocyte retrieval, dydrogesterone tablets (10mg, three times a day) from Abbott Biologicals B.V. were taken orally, and micronized progesterone (Utrogestan R, 200 mg, twice daily) was administered vaginally. Between the 3rd and 5th day after egg retrieval, 1-2 embryos were transplanted. Support for the corpus luteum continued until the 12th-14th day after transplantation, with further decisions made based on the pregnancy status.
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