Chemicals used in these experiments were of reagent grade. Norepinephrine, prazosin, and adenosine were obtained from Sigma-Aldrich (Saint Quentin- Fallavier, France) and cirazoline from Tocris (Lille, France). They were prepared as stock solutions in distilled water and kept frozen (−20 °C) until just prior to dilution in saline solution.
Cirazoline
Manufactured by Bio-Techne
Sourced in United Kingdom
Cirazoline is a laboratory reagent used for research purposes. It is a chemical compound that serves as a core functional component in various experimental applications. The detailed specifications and intended uses of Cirazoline are not provided in order to maintain an unbiased and factual approach.
Automatically generated - may contain errors
Lab products found in correlation
Prazosin, by Merck Group (3 mentions)
Norepinephrine, by Merck Group (2 mentions)
Sch23390, by Bio-Techne (2 mentions)
Skf38393, by Abcam (2 mentions)
Adenosine, by Merck Group (1 mentions)
Doxorubicin, by Bio-Techne (1 mentions)
Methoxamine, by Merck Group (1 mentions)
A61603, by Bio-Techne (1 mentions)
Phenylephrine, by Merck Group (1 mentions)
Epinephrine, by Merck Group (1 mentions)
4 protocols using cirazoline
1
Vasoactive Compounds Preparation
2
Vasoactive Drug Evaluation Protocol
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Drugs were as follows: A61603 (N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide) (Tocris #1052); ABT-866 (N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide) (synthesized by Synterys, Union City, CA); cirazoline (Tocris now R&D # 0888); dobutamine (Fisher Scientific, ICN#15978010); doxorubicin (Tocris #2252); epinephrine (Sigma #E4375); methoxamine (Sigma #M6524); midodrine (MP-Bio #155717); norepinephrine (Sigma #N5785); oxymetazoline (Tocris #1142); phenylephrine (Sigma #P-6126); propranolol (Fluka #82066); and ST-1059 (Toronto Research Chemicals #S686650).
3
Adrenergic and Dopaminergic Receptor Modulation
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ECH and prazosin (an antagonist of α1-adrenergic receptors [AR]) were acquired from Sigma-Aldrich (USA). The D1-like dopaminergic receptor agonist SKF38393 was obtained from Abcam (UK). SCH 23390 (DRD1/5 antagonist) and cirazoline (an α1-AR agonist) were purchased from Tocris Bioscience (UK). All other chemicals employed in this research were of analytical grade.
4
Adrenergic and Dopaminergic Receptor Modulation
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ECH and prazosin (an antagonist of α1-adrenergic receptors [AR]) were acquired from Sigma-Aldrich (USA). The D1-like dopaminergic receptor agonist SKF38393 was obtained from Abcam (UK). SCH 23390 (DRD1/5 antagonist) and cirazoline (an α1-AR agonist) were purchased from Tocris Bioscience (UK). All other chemicals employed in this research were of analytical grade.
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