Cisapride monohydrate and quinine were obtained from Sigma Aldrich (Saint Louis, MO). Verapamil hydrochloride was obtained from MP Biomedicals (Solon, OH). Quinidine was obtained from Tocris (Bristol, UK). Frozen stocks of human iPSC-CMs from a healthy individual (SCVI-480CM) were obtained from Joseph C. Wu, MD, PhD at the Stanford Cardiovascular Institute Biobank. The iPSC-CM line was derived from an African American female donor, and was approved by Stanford University Human Subjects Research Institutional Review Board. The cells were differentiated to cardiomyocytes as described previously (Churko et al., 2013 (link); Burridge et al., 2014 (link)). HEK-HCN1 (CT6114) cells were obtained from Charles River (Wilmington, MA).
Quinidine
Manufactured by Bio-Techne
Sourced in United Kingdom
Quinidine is a chemical compound used in laboratory settings. It is a crystalline powder that functions as a cardiac depressant and has applications in various research and analytical procedures. The core function of Quinidine is to serve as a reference standard or a reagent in various laboratory experiments and analyses.
Automatically generated - may contain errors
Lab products found in correlation
Verapamil hydrochloride, by MP Biomedicals (2 mentions)
Hek hcn1 ct6114 cells, by Charles River Laboratories (2 mentions)
Quinine, by Merck Group (2 mentions)
Cisapride monohydrate, by Merck Group (2 mentions)
Dmem f12, by Thermo Fisher Scientific (2 mentions)
Lamotrigine, by Merck Group (1 mentions)
Ryanodine, by Merck Group (1 mentions)
Nifedipine, by Merck Group (1 mentions)
Cytosine β d arabinofuranoside ara c, by Merck Group (1 mentions)
Veratridine, by Abcam (1 mentions)
Cisapride, by Abcam (1 mentions)
Bovine serum albumin (bsa), by Thermo Fisher Scientific (1 mentions)
E 4031, by Abcam (1 mentions)
Triton x 100, by Thermo Fisher Scientific (1 mentions)
Fetal bovine serum (fbs), by Merck Group (1 mentions)
4 aminopyridine, by Merck Group (1 mentions)
Alexa fluor 488 conjugated goat anti rabbit, by Thermo Fisher Scientific (1 mentions)
Bay k 8644, by Abcam (1 mentions)
Verapamil, by Abcam (1 mentions)
Carbamazepine, by Merck Group (1 mentions)
3 protocols using quinidine
1
Cardiotoxicity Screening using iPSC-CMs
2
Cardiac Ion Channel Pharmacology Assay
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Bay K 8644, veratridine, terfenadine, cisapride, anti-cTnT (1:400) antibody, E-4031 and verapamil were purchased from Abcam (Cambridge, MA, USA). Quinidine was from Tocris Bioscience (Bristol, UK). Nifedipine, 4-aminopyridine, fetal bovine serum (FBS), cytosine β-D-arabinofuranoside (ARA-C), poly-D-lysine and epinephrine, FLA-365, ryanodine, lamotrigine, carbamazepine, phenytoin and all inorganic salts were purchased from Sigma-Aldrich (St. Louis, MO, USA). Bovine serum albumin, DMEM/F12, Triton™ X-100, Alexa Fluor® 488-conjugated goat anti-rabbit were from ThermoFisher Scientific (Waltham, MA). The Ca2+ dye Fluo-8/AM was from TEFLab (Austin, TX, USA).
3
Pharmacological Evaluation of Human iPSC-Cardiomyocytes
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Cisapride monohydrate and quinine were obtained from Sigma Aldrich (Saint Louis, MO). Verapamil hydrochloride was obtained from MP Biomedicals (Solon, OH). Quinidine was obtained from Tocris (Bristol, UK). Frozen stocks of human iPSC‐CMs from a healthy individual (SCVI‐480CM) were obtained from Joseph C. Wu, MD, PhD, at the Stanford Cardiovascular Institute Biobank. The iPSC‐CM line was derived from an African‐American female donor and was approved by Stanford University Human Subjects Research Institutional Review Board. The cells were differentiated to cardiomyocytes as described previously (Burridge et al., 2014 (link); Churko et al., 2013 (link)). HEK‐HCN1 (CT6114) cells were obtained from Charles River (Wilmington, MA).
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