Discovery mri 750

Manufactured by GE Healthcare

Sourced in United States

The Discovery MRI 750 is a magnetic resonance imaging (MRI) system designed for diagnostic imaging. It provides high-quality imaging capabilities to support healthcare professionals in their clinical practice.

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Lab products found in correlation

8 channel radiofrequency coil array, by GE Healthcare (3 mentions) Gadovist, by Bayer (1 mentions)

Spelling variants of this product

Discovery 750 (177 citations) GE 3T Discovery 750 MRI (3 citations) 750 Discovery MRI scanner (3 citations) GE 750 Discovery MRI scanner (3 citations) GE Discovery MRI 750 3.0 T (2 citations) GE Discovery 750 MRI (2 citations) GE 750 Discovery 3 T MRI system (2 citations) 3.0T Discovery 750 MRI scanner (2 citations)

5 protocols using discovery mri 750

Resting-state fMRI and Structural Imaging

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All participants were scanned using a 3T GE MRI scanner (Discovery MRI 750; GE Medical Systems, Waukesha, WI) equipped with an 8-channel radiofrequency coil array (GE Healthcare, Waukesha, WI). The resting-state fMRI data were collected using T2*-weighted Echo Planar Imaging (EPI) sequence (TR/TE/FA: 2150 ms/22ms/79°, matrix: 64 × 64, FOV: 22.4 cm, slice thickness: 3.5 mm, voxel size: 3.5 mm x 3.5 mm x 3.5 mm, slices: 40 sagittal) using thin slices and short echo time in order to minimize signal dropout in the ventromedial prefrontal cortex. Each participant was instructed during the resting-state scan (~10 min) to remain “calm, still, and awake” with their eyes open fixating on a cross back-projected onto a screen via an LCD projector (Avotec, Stuart, FL). High-resolution T1-weighted structural imaging data were acquired using a weighted BRAVO pulse sequence (TI: 450ms, TR/TE/flip angle (FA): 8.16 ms/3.2 ms/12°, matrix: 256 × 256 × 160, field of view (FOV): 215.6 mm, slice thickness: 1 mm, voxel size: 1 mm x 1 mm x 1 mm, slices: 156).

Pessin S., Walsh E.C., Hoks R.M., Birn R.M., Abercrombie H.C, & Philippi C.L. (2022). Resting-state neural signal variability in women with depressive disorders. Behavioural brain research, 433, 113999.

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Resting-State fMRI Acquisition Protocol

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All participants were scanned using a 3T GE MRI scanner (Discovery MRI 750; GE Medical Systems, Waukesha, WI) equipped with an 8-channel radiofrequency coil array (GE Healthcare, Waukesha, WI). The resting-state fMRI data were collected using T2*-weighted Echo Planar Imaging (EPI) sequence (TR/TE/FA: 2150 ms/22ms/79°, matrix: 64 x 64, FOV: 22.4 cm, slice thickness: 3.5 mm, voxel size: 3.5 mm x 3.5 mm x 3.5 mm, slices: 40 sagittal) using thin slices and short echo time in order to minimize signal dropout in the ventromedial prefrontal cortex. Each participant was instructed during the resting-state scan (~10 min) to remain “calm, still, and awake” with their eyes open fixating on a cross back-projected onto a screen via an LCD projector (Avotec, Stuart, FL). High-resolution T1-weighted structural imaging data were acquired using a weighted BRAVO pulse sequence (TI: 450ms, TR/TE/flip angle (FA): 8.16 ms/3.2 ms/12°, matrix: 256 x 256 x 160, field of view (FOV): 215.6 mm, slice thickness: 1 mm, voxel size: 1 mm x 1 mm x 1 mm, slices: 156).

Philippi C.L., Leutzinger K., Pessin S., Cassani A., Mikel O., Walsh E.C., Hoks R.M., Birn R.M, & Abercrombie H.C. (2022). Neural signal variability relates to maladaptive rumination in depression. Journal of psychiatric research, 156, 570-578.

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In Vivo Metabolism and Biodistribution of DATS@MION-PEG-LF Nanoparticles

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Like almost all nanoparticles, intravenously administered MIONs are eventually cleared by mononuclear phagocytic system such as liver [28 (link)]. To investigate the in vivo metabolism and biodegradation of DATS@MION-PEG-LF, BALB/c-nu mice (15 g, 4 w, n = 6) were injected via the tail vein with 10 mg/kg of the DATS@MION-PEG-LF nanoparticles. Six mice were injected with same volume of saline and underwent same procedures as control. In vivo MRI scan was performed on 3-T MRI scanner (Discovery MRI 750, GE Medical Systems, Milwaukee, WI, USA) with an animal 8-channel phased-array coil with the following parameters: FSE T2 Fat Suppress, slice thickness: 1.0 mm, spacing: 0.1 mm, TR: 4167.0 ms, TE: 68.0 ms, refocus flip angle: 142°, echo train length: 24, and bandwidth: 31.25 kHz. T2-weighted MRI was used to detect the aggregation of nanoparticles in mouse livers by evaluating the calculated signal intensity. The signal intensities of nanoparticles at 6, 12, 24 h, 2, 4, 6, 8, 10, 12, and 14 days after injection were obtained in a region of interest (liver region) placed at the fixed site on matched slices. Signal to noise ratio (SNR) were calculated to compare the relative signal intensity. Repeat the protocols, and the SNRs of iron nanoparticles in mouse brains and hearts were evaluated within 48 h to assess the biodistribution of nanoparticles in brain and heart.

Sun X., Wang Y., Wen S., Huang K., Huang J., Chu X., Wang F, & Pang L. (2021). Novel controlled and targeted releasing hydrogen sulfide system exerts combinational cerebral and myocardial protection after cardiac arrest. Journal of Nanobiotechnology, 19, 40.

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Resting-State fMRI Acquisition Protocol

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All structural and functional magnetic resonance imaging (MRI) data were acquired using a 3T GE MRI scanner (Discovery MRI 750; GE Medical Systems, Waukesha, WI) equipped with an 8-channel radio-frequency coil array (GE Healthcare, Waukesha, WI). High-resolution T1-weighted structural images were acquired using a weighted BRAVO pulse sequence (TI: 450ms, TR/TE/flip angle (FA): 8.16ms/3.2ms/12°, matrix: 256×256×160, field of view (FOV): 215.6mm, slice thickness: 1mm, voxel size: 1mm×1mm×1mm³, slices: 156). rs-fMRI images were acquired using T2*-weighted Echo Planar Imaging (EPI) sequence (TR/TE/FA: 2150ms/22ms/79˚, matrix: 64×64, FOV: 22.4cm, slice thickness: 3.5mm, voxel size: 3.5mm×3.5mm×3.5mm³, slices: 40 sagittal) using thinner slices and shorter echo time in order to minimize signal dropout in ventromedial prefrontal cortex. For the resting-state scan (~10 minutes), the participants were instructed to remain “calm, still, and awake” with their eyes open fixating on a cross back-projected onto a screen via an LCD projector (Avotec, Stuart, FL).

Philippi C.L., Cornejo M.D., Frost C.P., Walsh E.C., Hoks R.M., Birn R, & Abercrombie H.C. (2018). Neural and behavioral correlates of negative self‐focused thought associated with depression. Human Brain Mapping, 39(5), 2246-2257.

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Gadolinium-Enhanced 3T MRI Examination of Labyrinth

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All patients had 3T MRI examination before and after intravenous administration of gadolinium-based contrast material. MRI examinations were carried out on a General Electric Discovery MRI 750 ® (General Electric Healthcare) with a 16-channel head-neck-spine coil.
We performed FIESTA-C sequences before contrast administration. Axial T1-weighted spinecho images were acquired after a single intravenous administration of Gadobutrol (Gadovist ® , Bayer Healthcare) at a dose of 0.1 mmol/kg [21] .
FIESTA-C is a refocused steady-state gradient echo sequence that provides high signals from tissues with elevated T2/T1 ratios and an excellent spatial resolution [22] . The FIESTA-C sequence was performed in the plane of the lateral semicircular canal with the following parameters: TR, 7 ms; TE, 2.8 ms; number of excitations (NEX), 1; matrix size, 484x484; flip angle, 60°; bandwidth, 83.3 kHz; and 0.3 mm slice thickness covering the labyrinth with a 20 cm field of view. We employed the autocalibrating reconstruction for cartesian (ARC) parallel imaging technique with an acceleration factor of 2 and a scan time of 4 min and 40 sec. The T1-weighted spin-echo sequence was performed in the axial plane with the following parameters: TR, 580 ms; TE, 19 ms; NEX, 2; spacing between slices, 1.7 mm; matrix size, 416x288; and 1.5 mm slice thickness covering the labyrinth with a 16.5 cm field of view.

Eliezer M., Poillon G., Maquet C., Gillibert A., Horion J., Marie J.P., Guichard J.P., Magne N, & Attyé A. (2019). Sensorineural hearing loss in patients with vestibular schwannoma correlates with the presence of utricular hydrops as diagnosed on heavily T2-weighted MRI. Diagnostic and interventional imaging, 100(5).

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