Sorafenib tosylate was purchased from BIOSYNTH Carbosynth (Compton, Newbury, United Kingdom). Cremophor EL, tetraglycol, triethylamine, and polyvinylpyrrolidone (PVP K 30) (average molecular weight 40 kDa) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Triacetin, isopropyl myristate (IPM), soybean oil, corn oil, tween 80, span 80, span 20, mineral oil, and glycerin were acquired from Daejung Chemicals Co. (Siheung, South Korea). Peceol, labrafil M 1994 CS, labrafil M 2125, labrasol, transcutol P, lauroglycol 90, capryol 90, and labrafac lipophile WL 1349 were obtained from Gattefossé (Saint-Priest Cedex, France). Capmul MCM and captex 355 were gifted from Abitec Corporation (Columbus, OH, USA). Propylene glycol, tween 20, olive oil, and phosphoric acid were purchased from Duksan Pure Chemical (Ansan, South Korea). Polyethylene glycol (PEG) 400 was purchased from Samchun Pure Chemical (Gyeonggi-Do, South Korea). Colloidal silica (Aerosil® 200 Pharma) was purchased from Evonik industries AG (Essen, Germany). Ethanol (EtOH) and high-performance liquid chromatography (HPLC)-grade acetonitrile (ACN) were purchased from Honeywell Burdick & Jackson® (Muskegon, MI, USA). All other chemicals used were of the analytical grade.
Polyethylene glycol peg 400
Manufactured by Samchun
Polyethylene glycol (PEG) 400 is a clear, colorless, odorless, and viscous liquid. It is a widely used compound in various industries, including pharmaceutical, personal care, and industrial applications. PEG 400 serves as a solvent, humectant, and plasticizer. It has a molecular weight range of 380-420 g/mol.
Automatically generated - may contain errors
Lab products found in correlation
Hplc grade acetonitrile, by Avantor (2 mentions)
2 hydroxypropyl β cyclodextrin, by Merck Group (2 mentions)
Poloxamer 407, by BASF (2 mentions)
Poloxamer 188, by BASF (2 mentions)
Tween 80, by Samchun (2 mentions)
Triethylamine, by Merck Group (1 mentions)
Cremophor el, by Merck Group (1 mentions)
Sorafenib tosylate, by Biosynth (1 mentions)
Lauroglycol 90, by Gattefosse (1 mentions)
Labrafac lipophile wl 1349, by Gattefosse (1 mentions)
Capryol 90, by Gattefosse (1 mentions)
Peceol, by Gattefosse (1 mentions)
Tetraglycol, by Merck Group (1 mentions)
Polyvinylpyrrolidone pvp k30, by Merck Group (1 mentions)
Labrafil m 2125, by Gattefosse (1 mentions)
Glycerin, by Daejung Chemicals (1 mentions)
Transcutol p, by Gattefosse (1 mentions)
Labrasol, by Gattefosse (1 mentions)
Span 80, by Daejung Chemicals (1 mentions)
Tween 80, by Daejung Chemicals (1 mentions)
4 protocols using polyethylene glycol peg 400
1
Sorafenib Tosylate Formulation Development
2
Synthesis and Formulation of ZPF Compounds
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(S)-ZPF, (R)-ZPF and (RS)-ZPF were synthesized from the laboratory of Prof. S.H. Jung (Chungnam National University, Daejeon, Korea). d -alpha tocopheryl polyethylene glycol 1000 succinate (TPGS) and 2-hydroxypropyl-β-cyclodextrin (HPCD) were purchased from Sigma-Aldrich (Steinheim, Switzerland). Poloxamer 188 and poloxamer 407 were purchased from BASF SE (Ludwigshafen, Germany). Cremophor EL, polyethylene glycol (PEG) 400, PEG 600, Tween 80, and propylene glycol (PG) were purchased from Samchun Chemical Co., Ltd. (Pyungtaek, Korea). HPLC-grade acetonitrile, methanol, n-hexane, and 2-propanol were from JT Baker (Phillipsburg, NJ, USA). Distilled water (DW) was used in this study. All solvents were analytical grade and used without further purification.
3
Tadalafil Formulation Development and Characterization
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Tadalafil was obtained from Korea United Pharm. Inc. (Seoul, Korea). 2-Hydroxypropyl-b-cyclodextrin (HPCD) was purchased from Sigma-Aldrich (Steinheim, Germany). Polyethylene glycol (PEG) 400, tween 80, OA, and triethanolamine were purchased from Samchun chemical Co. Ltd (Pyungtaek, Korea). HPLC grade acetonitrile was from JT Baker (Phillipsburg, NJ). All the solvents were of analytical grade and used without further purification.
4
Formulation and Evaluation of Saquinavir
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Saquinavir was purchased from Vivagen Co., Ltd. (Seongnam, Korea). Capryol™ 90, Labrasol®, propylene glycol, Tween® 80, Labrafac® CM 10, and urethane (ethyl carbamate) were obtained from Daejung Chemicals & Metal Co., Ltd. (Siheung, Korea). Cremophor® ELP, polyvinylpyrrolidone (PVP) K90, PVP K30, hydroxypropyl methylcellulose (HPMC) 2910, poloxamer 407, poloxamer 188, copovidone, and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®) were purchased from BASF (Cleveland, OH, USA). Polyethylene glycol (PEG) 400 was provided by Samchun Pure Chemical (Pyeongtaek, Korea). Transcutol® HP was obtained from Gattefosse (Lyon, France). Male specific pathogen-free/vial antibody-free outbred Sprague-Dawley (SD) rats (275–300 g) were purchased from Orient Bio Inc. (Seongnam, Korea). All solvents used in the experiments were of high-performance liquid chromatography (HPLC) grade.
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