The granulated EVA copolymer was mixed with 0.4, 0.8, and 1.6 wt% of crosslinking agent, respectively. Then, the mixture was treated by melt compounding in a twin-screw extruder (Thermo minilab II) with a screw speed of 100 rpm at 90 °C for 5 min. Then, the samples were cooled to room temperature.
Minilab 2
Manufactured by Thermo Fisher Scientific
The Minilab II is a compact, benchtop instrument designed for performing high-quality, automated nucleic acid extraction and purification. It utilizes magnetic bead-based separation technology to isolate DNA or RNA from a variety of sample types, including blood, tissue, and cell culture. The Minilab II provides consistent and reliable results, making it a useful tool for a range of applications in life science research and molecular diagnostics.
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Lab products found in correlation
2 protocols using minilab 2
1
Crosslinking of Granulated EVA Copolymer
2
Felodipine-PVP/VA Amorphous Solid Dispersions
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Already prepared amorphous solid dispersions (ASDs) of felodipine (FEL) and polyvinylpyrrolidone/vinyl acetate copolymer (PVP/VA) were provided by the AstraZeneca based co-authors.
Amorphous solid dispersions of FEL-PVP/VA in mass ratios of 30:70 and 50:50 were prepared by hot-melt extrusion (HME). Components were weighed on an analytical balance and added to a small sterilin pot. The API and polymer were then blended in a Turbula blender at 23 rpm for 4 minutes. Extrusion was carried out on a Thermofisher Haake Minilab II hot-melt extruder using a barrel temperature and screw speed of 130 • C and 30 rpm, respectively. The extrudate exited the extruder as long rods approximately 2 mm in diameter, which were cut into smaller sections and milled to form a powder. Each powder was then dried under vacuum and stored at room temperature in a desiccator prior to use.
Amorphous solid dispersions of FEL-PVP/VA in mass ratios of 30:70 and 50:50 were prepared by hot-melt extrusion (HME). Components were weighed on an analytical balance and added to a small sterilin pot. The API and polymer were then blended in a Turbula blender at 23 rpm for 4 minutes. Extrusion was carried out on a Thermofisher Haake Minilab II hot-melt extruder using a barrel temperature and screw speed of 130 • C and 30 rpm, respectively. The extrudate exited the extruder as long rods approximately 2 mm in diameter, which were cut into smaller sections and milled to form a powder. Each powder was then dried under vacuum and stored at room temperature in a desiccator prior to use.
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