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17 aminogeldanamycin

Manufactured by BOC Sciences
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17-aminogeldanamycin is a chemical compound that functions as a heat shock protein 90 (Hsp90) inhibitor. It is a derivative of the natural product geldanamycin, which has been utilized in research studies. 17-aminogeldanamycin can be used as a research tool to investigate the role of Hsp90 in various biological processes.

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Lab products found in correlation

Geldanamycin, by Merck Group (2 mentions) Trametinib, by Selleck Chemicals (1 mentions) Vemurafenib, by Selleck Chemicals (1 mentions)

2 protocols using 17 aminogeldanamycin

1

Synergistic Effect of Targeted Inhibitors

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Vemurafenib and trametinib were purchased from Selleck Chemicals LLC (Houston, TX, USA), geldanamycin from Sigma-Aldrich and 17-aminogeldanamycin from BOC Sciences (Shirley, NY, USA). Chemical formulas of geldanamycin and 17-aminogeldanamycin were prepared using ISIS/Draw (version 2.3). Drug stocks were prepared in DMSO. For experiments, drugs were dissolved in the culture medium to final concentrations as following: 5 μM Vemurafenib (PLX), 50 nM trametinib (TRA), 0,1 and 0,4 μM geldanamycin (GEL) and 17-aminogeldanamycin (AG).
Mielczarek-Lewandowska A., Sztiller-Sikorska M., Osrodek M., Czyz M, & Hartman M.L. (2019). 17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes. Apoptosis, 24(7), 596-611.
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2

Geldanamycin and 17-Aminogeldanamycin Sources

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17-Aminogeldanamycin was purchased from BOC Sciences (Shirley, NY, USA), and geldanamycin was purchased from Sigma-Aldrich (St Louis, MO, USA).
Hartman M.L., Rogut M., Mielczarek-Lewandowska A., Wozniak M, & Czyz M. (2020). 17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-κB) Activity in Patient-Derived Melanoma Cell Lines. International Journal of Molecular Sciences, 21(11), 3749.
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