Finnigan flash ea 1112

Manufactured by Thermo Fisher Scientific

Sourced in United States

The Finnigan Flash EA 1112 is an elemental analyzer designed for the determination of carbon, hydrogen, nitrogen, and sulfur in a variety of organic and inorganic solid and liquid samples. It utilizes a combustion-based technique to quantify the elemental composition of the sample.

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Lab products found in correlation

Vnmrs 600 mhz spectrometer, by Agilent Technologies (1 mentions) Nicolet is50, by Thermo Fisher Scientific (1 mentions) Spectrum 400 spectrometer, by PerkinElmer (1 mentions) Icap 6300 duo, by Thermo Fisher Scientific (1 mentions)

Spelling variants of this product

Flash EA 1112 (198 citations) Finnigan Flash EA (3 citations) Thermo Finnigan EA 1112 Series Flash Elemental Analyzer (3 citations) Thermo Finnigan EA 1112 Series Flash Elemental Analyser (2 citations)

4 protocols using finnigan flash ea 1112

Nanoparticle Isolation and Characterization

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Nanoparticles were isolated by centrifugation at 15,000×g for 30 min at 15 °C (Hettich Universal 32 R; Tuttlingen, Germany). The pellets obtained after separation were freeze-dried (Genesis SQ freeze-drier; Virtis, USA) and weighed after this process. Production yield was determined according to the following equation (Eq. 1):

Yield (%) = \frac{Freeze - dried nanoparticle weight}{Theoretical total solids weight} \times 100

For elemental analysis, nanoparticles before and after isolation by centrifugation were freeze-dried and analyzed for their content in carbon, oxygen, and nitrogen (Finnigan FLASH EA 1112; Thermo Scientific, Waltham (MA), USA), with the nitrogen being specific for CS and therefore allowing differentiation between both polymers. Solutions of the starting polymers, CS and CMβG, were also freeze-dried and analyzed as controls.

Cordeiro A.S., Farsakoglu Y., Crecente-Campo J., de la Fuente M., González S.F, & Alonso M.J. (2021). Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen delivery. Drug Delivery and Translational Research, 11(4), 1689-1702.

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Chemical Conjugation Analysis of R9G10-GC

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FT-IR spectroscopy was used to confirm the chemical conjugation between the R₉G₁₀ and GC (Nicolet IS50, Thermo Fisher Scientific; Waltham, MA, USA). The GC or R₉G₁₀-GC samples were mixed with dry KBr in a fine powder form, and a disk was prepared through compression. Each disk was scanned over a wavenumber region of 400–2000 cm⁻¹ (resolution, 4 cm⁻¹; scan rate, 4 mm/s). ¹H NMR spectra were recorded using a Varian VNMRS 600 MHz spectrometer. Samples were dissolved in D₂O ([sample] = 10 mg/mL). The degree of substitution of R₉G₁₀ conjugated to GC was calculated from elemental analysis (Thermo Finnigan Flash EA 1112, Bremen, Germany).

Jeong E.J., Lee J., Kim H.S, & Lee K.Y. (2021). In Vitro Cellular Uptake and Transfection of Oligoarginine-Conjugated Glycol Chitosan/siRNA Nanoparticles. Polymers, 13(23), 4219.

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Analytical Characterization of Organic Compounds

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All chemicals are commercially available and used as received. The elemental analyses for C, H, and N were carried out on a Thermo Finnigan Flash EA 1112 (Thermo Scientific, Hudson, NH, USA). The infrared spectra were obtained on a Perkin-Elmer Spectrum 400 spectrometer with samples as KBr pellets in the region 4000–400 cm-1. The UV-vis spectra were obtained using a Shimadzu UV-vis-NIR 1600 spectrophotometer. ¹H-NMR spectra were recorded on a JEOL FT-NMR lambda 400 MHz spectrometer. The solvent was DMSO-d₆. The chemical shifts were reported in ppm using the residual protonated solvent as the reference.

Samie N., Haerian B.S., Muniandy S., Marlina A., Kanthimathi M.S., Abdullah N.B., Ahmadian G, & Aziddin R.E. (2016). Mechanism of Action of the Novel Nickel(II) Complex in Simultaneous Reactivation of the Apoptotic Signaling Networks Against Human Colon Cancer Cells. Frontiers in Pharmacology, 6, 313.

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Quantitative Analysis of Sodium-Titanium Compounds

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Hydrogen and sulphur contents were determined using a “Thermo Finnigan Flash EA 1112” analyser. Sodium was determined via optical emission spectroscopy with an inductively coupled plasma (ICP-OES) using a “Thermo Fisher Scientific iCAP 6300 Duo” evaluating the emission line at 589.5 nm.
The numbers of titanium ions per formula unit (with respect to sodium) were determined via wavelength-dispersive X-ray fluorescence (XRF) measurements on a “PANalytical Axios” spectrometer evaluating the intensities for the Na-K_α and Ti-K_α transitions. Samples were prepared from ca. 100 mg of analyte and 100 mg wax (Hoechst wax) performing uniaxial pressing (PerkinElmer hydraulic hand-press). Intensity ratios and sodium intensities were calibrated against linear regressions for three different mixtures of Na₂S and TiS₂ with R(Na/Ti) = N(Na) ≈ 0.4, 0.7, and 1.0 to account for instability/correlation of the titanium signal.

Wiedemann D., Suard E, & Lerch M. (2019). Structural complexities and sodium-ion diffusion in the intercalates NaxTiS2: move it, change it, re-diffract it. RSC Advances, 9(48), 27780-27788.

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