Fluoxetine

Manufactured by Fujifilm

Sourced in Japan

Fluoxetine is a laboratory analytical instrument used for the detection and quantification of the chemical compound fluoxetine. It is a versatile tool employed in various scientific and research applications.

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5 protocols using fluoxetine

Fluoxetine Affects Rodent Behavior

Cited 2 times

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The selective serotonin reuptake inhibitor (SSRI) fluoxetine was purchased from Wako Pure Chemical Industries, Ltd. A fluoxetine dose of 10 mg/kg was dissolved in 0.2 ml of 0.9% saline and administered intraperitoneally (i.p.) approximately 10 minutes before tests. This dose of fluoxetine was selected due to reports from previous studies finding that fluoxetine administration at this dose causes several behavioral changes in rodents^{55 (link),56 (link)}. As a control treatment, the equivalent volume of saline (SAL) was given to animals.

Lee Y.A, & Goto Y. (2018). The Roles of Serotonin in Decision-making under Social Group Conditions. Scientific Reports, 8, 10704.

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Preparation of Pharmacological Agents

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Decynium‐22 was purchased from Tocris Bioscience, corticosterone was purchased from Sigma‐Aldrich, and fluoxetine was purchased from FUJIFILM Wako Pure Chemical. Stock solution of decynium‐22 and corticosterone was prepared in DMSO at concentration of 1 mM and 10 mM, respectively. Stock solution of 10 mM fluoxetine was prepared in distilled water. These stock solutions were stored at −30℃ and were diluted in Ringer's solution freshly before the experiments.

Sonobe T., Akiyama T., Du C, & Pearson J.T. (2019). Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia‐reperfusion in the rat heart in vivo. Physiological Reports, 7(22), e14297.

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Fluoxetine Exposure in Mice

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Fluoxetine (0.8 mg/mL; Wako Pure Chemical Industries, Osaka, Japan) was supplied to group-housed male mice in drinking water from when the mice were 8-weeks-old until the end of the experiment. Fluoxetine-treated mice were subjected to the behavioural tests (n = 16 cages) described above and gene expression analysis of the hippocampus (n = 8) was performed as described above.

Horii Y., Nagasawa T., Sakakibara H., Takahashi A., Tanave A., Matsumoto Y., Nagayama H., Yoshimi K., Yasuda M.T., Shimoi K, & Koide T. (2017). Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice. Scientific Reports, 7, 6991.

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Chemical Compound Acquisition for Research

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Erythromycin, clarithromycin, roxithromycin, diltiazem, ritonavir, ketoconazole, fluconazole, cimetidine, ticlopidine, omeprazole, fluvoxamine, paroxetine, fluoxetine, quinidine, aflatoxin B1, and sterigmatocystin were obtained from Wako, Japan. Gestodene and mifepristone were obtained from Tokyo Chemical Industry, Japan. G418 was obtained from Funakoshi, Japan. Ethinylestradiol, rifampicin, tienilic acid, terbinafine, hypoxanthine, aminopterin, and thymidine (HAT) and 4,6-diamidino-2-phenylindole (DAPI) were obtained from Sigma Aldrich, USA. All other chemicals were of the highest grade commercially available.

Satoh D., Iwado S., Abe S., Kazuki K., Wakuri S., Oshimura M, & Kazuki Y. (2017). Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies. PLoS ONE, 12(10), e0187072.

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Chemicals and Reagents for Neuroscience Research

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Ethylenediamine-N,N,N',N'-tetraacetic acid (EDTA) was obtained from Dojindo (Kumamoto, Japan). Fluoxetine, imipramine, venlafaxine, bupropion, and other chemicals were obtained from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan).

Kawai H., Iwadate R., Ishibashi T., Kudo N., Kawashima Y, & Mitsumoto A. (2019). Antidepressants with different mechanisms of action show different chronopharmacological profiles in the tail suspension test in mice. Chronobiology international, 36(9).

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