Architect platform

Manufactured by Abbott

Sourced in United States, Germany, Ireland

The Architect platform is a fully automated, high-throughput, real-time clinical chemistry and immunoassay testing system designed for use in hospital and reference laboratories. It provides efficient and reliable diagnostic testing capabilities across a wide range of clinical chemistry and immunoassay parameters.

Automatically generated - may contain errors

Lab products found in correlation

Cobas analytics immunoanalyzers, by Roche (3 mentions) Anti human lfabp mouse monoclonal antibodies, by Sekisui (2 mentions) Pierce bca protein assay kit, by Thermo Fisher Scientific (2 mentions) Chemiluminescent microparticle immunoassay, by Abbott (2 mentions) Quantikine hs il 6 elisa, by R&D Systems (1 mentions) Acl top 700, by Werfen (1 mentions) Cell dyn sapphire platform, by Abbott (1 mentions) Elisa, by R&D Systems (1 mentions) Modular analytics e170, by Roche (1 mentions) Meso scale discovery platform, by MSD (1 mentions) Meso scale discovery platform, by Mesoscale (1 mentions) Cobas taqman hbv test, by Roche (1 mentions) Cobas taqman hbv test kit, by Roche (1 mentions) Lsm 710 confocal laser scanning microscope, by Zeiss (1 mentions) Advia 120 hematology system, by Siemens (1 mentions) Elisa kit, by R&D Systems (1 mentions) Qiaamp powerfecal dna kit, by Qiagen (1 mentions) Reflotron gpt alt tests, by Roche (1 mentions) Nucleospin tissue dna kit, by Macherey-Nagel (1 mentions) Qiaamp minelute virus spin kit, by Qiagen (1 mentions)

54 protocols using architect platform

Fasting Plasma Lipid Profile

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Samples were collected from overnight fasted participants on the day of elective cardiac catheterization. Plasma aliquots were isolated from whole blood collected into EDTA tubes, maintained at 0 to 4°C immediately following phlebotomy, processed within 4 hours of blood draw, and stored at −80°C until analysis. Plasma levels of total cholesterol, low‐ and high‐density lipoprotein cholesterol, triglycerides, and high‐sensitivity C‐reactive protein were measured on the Architect platform (Abbott Diagnostics).

Hartiala J., Breton C.V., Tang W.H., Lurmann F., Hazen S.L., Gilliland F.D, & Allayee H. (2016). Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 5(8), e003947.

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Acute Biomarker Changes in ACS

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The endpoint for this angiographic and biomarker substudy were the temporal changes in levels of hs-TnT, NT-proBNP, CRP, IL-6, and GDF-15 during the acute phase of ACS and during follow-up. Blood samples in the PLATO trial were collected by direct venepuncture and plasma samples were frozen at −70°C and stored in aliquots in a central repository at Uppsala Biobank until biochemical analyses were performed at the Uppsala Clinical Research Center (UCR) laboratory, Uppsala, Sweden. Blood samples were obtained at baseline (median of about 10 h after admission), at discharge, and at 1- and 6-month post-randomization. Levels of hs-TnT, NT-proBNP, and GDF-15 were analysed with sandwich immunoassays on Cobas Analytics Immunoanalyzers (Roche Diagnostics). C-reactive protein was analysed using the Architect platform (Abbott Diagnostics). IL-6 was measured using Quantikine hs-IL-6 ELISA (R&D Systems Inc). All analyses were performed at UCR Laboratory at Uppsala University, Sweden.

Batra G., Renlund H., Kunadian V., James S.K., Storey R.F., Steg P.G., Katus H.A., Harrington R.A., Gibson C.M., Budaj A., Siegbahn A, & Wallentin L. (2022). Effects of early myocardial reperfusion and perfusion on myocardial necrosis/dysfunction and inflammation in patients with ST-segment and non-ST-segment elevation acute coronary syndrome: results from the PLATelet inhibition and patients Outcomes (PLATO) trial. European Heart Journal. Acute Cardiovascular Care, 11(4), 336-349.

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Evaluation of COVID-19 Patients with Pulmonary Embolism

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Epidemiological, demographic, clinical, and laboratory examinations were collected from all subjects at the time of admission. The data recorded included time from symptom onset to hospital admission and to CTPA, medical treatment during hospitalization, thromboprophylaxis, respiratory support, clinical outcomes (acute respiratory failure, arrhythmia, ICU admission, or death), and strong-moderate PE risk factors. The CURB-65 score was calculated (27 (link)).
Laboratory data included complete blood count (Cell-Dyn Sapphire platform, Abbott Diagnostics, United States), coagulation, and kidney and liver function tests collected upon admission. In addition, baseline, peak, and prior-to-CTPA values of the following biomarkers were analyzed in each patient: fibrinogen, D-dimer (reported as D-dimer units (DDUs), ACL TOP 700, Instrumentation Laboratory), C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), and ferritin. In addition, high sensitive troponin I, interleukin-6 (IL-6), interleukin-10 (IL-10) (ELISA, R&D systems), N-terminal pro hormone B-type natriuretic peptide (NT pro-BNP) (Test 1 THL Module, ALI FAX; Architect platform, Abbott Diagnostics), and fibrinogen were also measured. Blood gas analyses were performed on the GEM 4000 platform (Werfen, Spain). D-dimer-to-ferritin, D-dimer-to-LDH, and D-dimer-to-CRP ratios were calculated.

Suarez Castillejo C., Toledo-Pons N., Calvo N., Ramon-Clar L., Martínez J., Hermoso de Mendoza S., Morell-García D., Bauça J.M., Berga F., Núñez B., Preda L., Sauleda J., Argente Castillo P., Ballesteros A., Martín L., Sala-Llinas E, & Alonso-Fernández A. (2022). A Prospective Study Evaluating Cumulative Incidence and a Specific Prediction Rule in Pulmonary Embolism in COVID-19. Frontiers in Medicine, 9, 936816.

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Subclinical Myocardial Injury Detection

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Hs-cTnI was measured from thawed plasma samples originally collected during the baseline examination from 2000 to 2004. The ARCHITECT platform (Abbott Diagnostics) was used to measure hs-cTnI and can detect concentrations as low as 1.2 ng/L (16 (link)). The coefficient of variation was 10% at a concentration of 3.0 ng/L. Subclinical myocardial injury was defined as hs-cTnI ≥4 and ≥6 ng/L in women and men, respectively, as previously described (5 (link)).

Patel K.V., Simek S., Ayers C., Neeland I.J., deFilippi C., Seliger S.L., Lonergan K., Minniefield N., Mentz R.J., Correa A., Yimer W., Hall M.E., Rodriguez C.J., de Lemos J.A., Berry J.D, & Pandey A. (2021). Physical Activity, Subclinical Myocardial Injury and Risk of Heart Failure Subtypes in Black Adults. JACC. Heart failure, 9(7), 484-493.

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Urine NGAL Measurement Protocol

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Urine samples for uNGAL testing were immediately centrifuged at 1500 rpm for 10 min, and the supernatant was stored at −70 °C for batched analysis. UNGAL was measured by chemiluminescent microparticle assay using an ARCHITECT platform (Abbott Diagnostics Inc., Abbott Park, IL, expressed as ng/mL).

Treeprasertsuk S., Wongkarnjana A., Jaruvongvanich V., Sallapant S., Tiranathanagul K., Komolmit P, & Tangkijvanich P. (2015). Urine neutrophil gelatinase-associated lipocalin: a diagnostic and prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients with AKI-prone conditions. BMC Gastroenterology, 15, 140.

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Biomarker Quantification in Venous Blood

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Venous blood samples were drawn at baseline visit from an antecubital vein into EDTA Vacutainer test tubes. Samples were placed immediately on ice and plasma separation was performed at −4°C. Plasma samples were frozen at −80°C until assay. B‐type natriuretic peptide (BNP) assay was performed on Architect platform (Abbott Diagnostics) and high‐sensitivity troponin T immunoassay was performed on Modular Analytics E170 (Roche Diagnostics).

Dahou A., Toubal O., Clavel M., Beaudoin J., Magne J., Mathieu P., Philippon F., Dumesnil J.G., Puri R., Ribeiro H.B., Larose É., Rodés‐Cabau J, & Pibarot P. (2016). Relationship Between QT Interval and Outcome in Low‐Flow Low‐Gradient Aortic Stenosis With Low Left Ventricular Ejection Fraction. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 5(10), e003980.

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Quantitative Serological Assay for HBV

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All of the serological testing was performed using the carbonylmetalloimmunoassay (CMIA) technique on the Architect platform (Abbott Diagnostics, Wiesbaden, Germany). The system provides standardized quantitative results for the HBsAg and anti-HBsAg, expressed as international units and milliInternational units (IU/mL and mIU/mL), respectively.

Minosse C., Coen S., Visco Comandini U., Lionetti R., Montalbano M., Cerilli S., Vincenti D., Baiocchini A., Capobianchi M.R, & Menzo S. (2016). Simple and Reliable Method to Quantify the Hepatitis B Viral Load and Replicative Capacity in Liver Tissue and Blood Leukocytes. Hepatitis Monthly, 16(10), e28751.

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Biomarker Profiling of MINOCA and MI-CAD

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Plasma was collected by venous puncture at baseline (a median of 15.1 and 8.9 hours from onset of symptoms for patients with MINOCA and MI‐CAD, respectively) and after 1 month in a subset of paired patients and stored in aliquots in −70 °C until analysis. Baseline blood samples were obtained in all patients before coronary angiography. Biomarker concentrations were centrally measured at the Uppsala Clinical Research Center Laboratory (Uppsala, Sweden): hs‐cTnT, NT‐proBNP, and GDF‐15 were analyzed on Cobas Analytics Immunoanalyzers (Roche Diagnostics); and hs‐CRP was analyzed on the Architect platform (Abbott Diagnostics). All analyses were done according to the instructions of the assay manufacturers and have been described in detail previously.²²

Hjort M., Eggers K.M., Lakic T.G., Lindbäck J., Budaj A., Cornel J.H., Giannitsis E., Katus H.A., Siegbahn A., Storey R.F., Becker R.C., Wallentin L, & Lindahl B. (2022). Biomarker Concentrations and Their Temporal Changes in Patients With Myocardial Infarction and Nonobstructive Compared With Obstructive Coronary Arteries: Results From the PLATO Trial. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 12(1), e027466.

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Biomarker Measurement in EDTA Plasma

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Ethylenediaminetetraacetic acid (EDTA) plasma samples were collected at randomization which always took place before invasive procedures. After acquisition, samples were stored in aliquots at -70 °C until analysis which was performed centrally at the Uppsala Clinical Research Center (UCR) Laboratory (Uppsala University, Uppsala, Sweden). Concentrations of hs-cTnT, NT-proBNP and GDF-15 were measured on Cobas Analytics Immunoanalyzers (Roche Diagnostics, Basel, Switzerland). Hs-cTnI and CRP concentrations were measured using the Architect platform (Abbott Diagnostics, Abbott Park, IL, USA).

Eggers K.M., Batra G., Lindahl B., Ghukasyan Lakic T., Lindbäck J., Budaj A., Cornel J.H., Giannitsis E., Katus H.A., Storey R.F., Becker R.C., Siegbahn A, & Wallentin L. (2024). Temporal biomarker concentration patterns during the early course of acute coronary syndrome. Clinical chemistry and laboratory medicine, 62(6).

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Urine Biomarkers for Organ Procurement

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After collection at time of organ procurement, urine samples were centrifuged at 1000×g for 10 minutes at 4°C, separated into 1 ml aliquots, and immediately stored at -80°C until biomarker measurement. The following urine biomarkers were measured: cystatin-C, albumin-to-creatinine ratio (UACR), interferon alpha (IFN), interleukin (IL-) 4, 6, 8, 10,18, kidney injury molecule-1 (KIM-1), liver-type fatty acid-binding protein (LFABP), neutrophil gelatinase associated lipocalin (NGAL), tumor necrosis factor alpha (TNF-α), chitinase-3-like 1 (YKL-40), epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP-1), osteopontin (OPN) and uromodulin (UMOD). NGAL measurement was performed using the Architect platform (Abbott Diagnostics). LFABP was measured using latex-enhanced immunoturbidimetry with anti-human LFABP mouse monoclonal antibodies (Sekisui Medical). All other urine biomarkers were measured using the Meso Scale Discovery platform (MSD, Gaithersburg, MD), which uses electrochemiluminescence detection combined with patterned arrays.

Mansour S.G., Khoury N., Kodali R., Virmani S., Reese P.P., Hall I.E., Jia Y., Yamamoto Y., Thiessen-Philbrook H.R., Obeid W., Doshi M.D., Akalin E., Bromberg J.S., Harhay M.N., Mohan S., Muthukumar T., Singh P., Weng F.L., Moledina D.G., Greenberg J.H., Wilson F.P, & Parikh C.R. (2022). Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLoS ONE, 17(3), e0264329.

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