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Decanoylcarnitine

Manufactured by Merck Group
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Decanoylcarnitine is a laboratory reagent used in research and analysis. It is a derivative of the naturally occurring compound carnitine, which plays a role in the transport and metabolism of fatty acids. Decanoylcarnitine can be utilized in various biochemical and analytical applications, but a detailed description of its intended use would require further information to maintain an unbiased and factual approach.

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Lab products found in correlation

Propionylcarnitine, by Merck Group (2 mentions) Acetylcarnitine, by Merck Group (2 mentions) Butyrylcarnitine, by Merck Group (2 mentions) Valerylcarnitine, by Merck Group (2 mentions) Hexanoylcarnitine, by Merck Group (2 mentions) Octanoylcarnitine, by Merck Group (2 mentions) Formic acid, by Merck Group (1 mentions) Hplc grade water, by Thermo Fisher Scientific (1 mentions) Formic acid, by Thermo Fisher Scientific (1 mentions) Methanol, by Thermo Fisher Scientific (1 mentions) Ethyl acetate, by Thermo Fisher Scientific (1 mentions) Optima lc ms grade acetonitrile, by Thermo Fisher Scientific (1 mentions) Glacial acetic acid, by Thermo Fisher Scientific (1 mentions) Acetyl d3 l carnitine hydrochloride, by Merck Group (1 mentions) Hplc grade methanol, by Merck Group (1 mentions) Acetonitrile, by Merck Group (1 mentions) Milli q water purification system, by Merck Group (1 mentions) Palmitoylcarnitine, by Thermo Fisher Scientific (1 mentions) Glycocholic acid, by Merck Group (1 mentions) 5 methylcytidine, by Merck Group (1 mentions)

5 protocols using decanoylcarnitine

1

Lipidomic Analysis of Biological Samples

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LC-MS grade water, methanol and acetonitrile were purchased from J.T. Baker (Center Valley, PA, USA). High-performance liquid chromatography (HPLC)-grade ethanol and acetone were purchased from Merck & Co. (Kenilworth, NJ, USA). Formic Acid was of American Chemical Society (ACS) reagent grade from Sigma-Aldrich (Saint Louis, MO, USA). Decanoylcarnitine, LysoPE(16:0/0:0), LysoPE(18:0/0:0) and PC(16:0/16:0) was purchased from Avanti Polar Lipid (Alabaster, AL, USA). Decanoylcarnitine and l-octanoylcarnitine were purchased from Sigma-Aldrich (Saint Louis, MO, USA).
Lau S.K., Lee K.C., Lo G.C., Ding V.S., Chow W.N., Ke T.Y., Curreem S.O., To K.K., Ho D.T., Sridhar S., Wong S.C., Chan J.F., Hung I.F., Sze K.H., Lam C.W., Yuen K.Y, & Woo P.C. (2016). Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis. International Journal of Molecular Sciences, 17(3), 307.
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2

Carnitine Quantification by LC-MS

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Glacial acetic acid and HPLC grade water were purchased from Fisher Scientific (Agawam, MA, USA). Optima LC-MS grade acetonitrile, methanol, ethyl acetate and formic acid were also purchased from Fisher Scientific. The following unlabeled standards were available and purchased from Sigma (St. Louis, MO, USA): acetylcarnitine (C2:0-CN), propionylcarnitine (C3:0-CN), butyrylcarnitine (C4:0-CN), valerylcarnitine (C5:0-CN), hexanoylcarnitine (C6:0-CN), octanylcarnitine (C8:0-CN) and decanoylcarnitine (C10:0-CN). As shown in Table S1 in the supplementary materials, the following stable isotope standards were available and purchased from Sigma (St. Louis, MO, USA), as well: acetyl-d3-L-carnitine hydrochloride (d3-C2:0-CN), butyryl-L-carnitine-N-methyl-d3 (d3-C4:0-CN), octanoyl-L-carnitine-N-methyl-d3 (d3-C8:0-CN), and decanoyl-L-carnitine-N-methyl-d3 (d3-C10:0-CN).
Vera N.B., Coy S.L., Laiakis E.C., Fornace AJ J.r., Clasquin M., Barker C.A., Pfefferkorn J.A, & Vouros P. (2020). Quantitation of Urinary Acylcarnitines by DMS-MS/MS Uncovers the Effects of Total Body Irradiation in Cancer Patients. Journal of the American Society for Mass Spectrometry, 31(3), 498-507.
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3

Comprehensive Metabolite Profiling Protocol

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HPLC-grade Methanol and acetonitrile (ACN) were purchased from Merk (Darmstadt, Germany). Formic acid was obtained from Fluka (Buchs, Switzerland). 5-Methylcytidine, octanoylcarnitine, glycocholic acid and decanoylcarnitine were purchased from Sigma-Aldrich (St. Louis, MO). Phytosphingosine, sphinganine and palmitoylcarnitine were purchased from Acros Organics (NewJersey, USA). Lysophosphatidylcholine (20:0) and lysophosphatidylcholine (18:2) were purchased from Larodan AB (Malmo, Sweden). Hypoxanthine, inosine, kynurenine, hippuric acid, citric acid, indoleacetic acid and L-2-chlorophenylalanine (internal standard) were obtained from Shanghai Jingchun Reagent Co. Acetyl-N-formyl-5-methoxykynurenamine (AFMK) and indolelactic acid were purchased from Haorui Chemicals and Seebio Biotech (shanghai) Co.,Ltd, respectively. Ultrapure water was prepared with a Milli-Q water purification system (Millipore, Bedford, MA, USA).
Tan G., Wang H., Yuan J., Qin W., Dong X., Wu H, & Meng P. (2017). Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer. Scientific Reports, 7, 46176.
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4

Comprehensive Metabolomic and Lipidomic Analysis

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All chemicals used were of the highest purity, and reagents used were of LC-MS grade. All chemicals for the metabolomics studies (L-phenylalanine, phenylpyruvic acid, xanthurenic acid, decanoylcarnitine, sebacic acid, L-tysorine, L-glutamic acid, taurine, succinic acid, creatinine, L-carnitine, pyroglutamic acid, eicosapentaenoic acid, linoleic acid, arachidonic acid, uric acid and citric acid) were purchased from Sigma-Aldrich® (St. Louis, MO). Sphinganine-1-phosphate was purchased from Avanti® Polar Lipids, Inc. (Alabaster, AL), N-decanoyglycine from Hit2Lead (San Diego, CA) and decanoylcarnitine from Tocris Bioscience (Bristol, UK). Standards for lipidomics have been previously described elsewhere (9 (link), 28 ) and covered all broad lipid classes.
Laiakis E.C., Wang Y.W., Young E.F., Harken A.D., Xu Y., Smilenov L., Garty G.Y., Brenner D.J, & Fornace AJ J.r. (2017). Metabolic Dysregulation after Neutron Exposures Expected from an Improvised Nuclear Device. Radiation research, 188(1), 21-34.
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5

Targeted Metabolomics Workflow for Dried Blood Spots

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Gradient grade water and LC-MS grade methanol for liquid chromatography plus the non LC-MS grade rinsing solvents 2-propanol and acetonitrile as well as formic acid (puriss.) and ammonia fluoride (puriss.) were purchased from Carl Roth (Carl Roth, Rothenfels, Germany). A collection of all l-amino acids and carnitine, acetylcarnitine, propionylcarnitine, butyrylcarnitine, valerylcarnitine, hexanoylcarnitine, octanoylcarnitine, decanoylcarnitine, lauroylcarnitine, myristoylcarnitine, palmitoylcarnitine and stearoylcarnitine, were purchased from Sigma-Aldrich (St. Louis, MO, USA).
The deuterated internal standards (IS) Cortisol 2H4, Progesterone 2H9, 17-Hydroxyprogesterone 2H8, 11-Deoxycortisol 2H5, 21-Deoxycortisol 2H8, Androstenedione 13C3, Corticosterone 2H4, 11-Deoxycorticosterone 13C3 were also products of Sigma-Aldrich (St. Louis, MO, USA). The deuterated amino acids and acylcarnitines were obtained from the MassChrom® Amino Acids and Acylcarnitines from Dried Blood kit from Chromsystems (Munich, Germany). Dried blood spot cards (TFN filter paper) were provided by CAMAG (Muttenz, Switzerland). Fresh whole blood was obtained from the local blood donation center (Basel, Switzerland).
Gaugler S., Rykl J., Wegner I., von Däniken T., Fingerhut R, & Schlotterbeck G. (2017). Extended and Fully Automated Newborn Screening Method for Mass Spectrometry Detection. International Journal of Neonatal Screening, 4(1), 2.
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