Agents: Glycerol monooleate (GMO, DIMODAN®MO/D KOSHER) was a present from Danisco Cultor (Brabrand, Denmark). N-methyl pyrrolidone (NMP) was purchased from Guangfu Smart Chemical Research Institute (Tianjin, China). Medium chain triglyceride (MCT) was purchased from Gracia Chemical Technology Co., Ltd. (Chengdu, China). Metronidazole (MTZ) was obtained from Huanggang SaiKang Pharmacy Co., Ltd. (purity ≥99.0%, Huanggang, China). MTZ tablets were produced by Kangmei Pharmaceutical Co., Ltd. (Jieyang, China). Ligature suture (3–0) was purchased from Johnson & Johnson Medical Ltd. (Shanghai, China). Porphyromonas gingivalis lipopolysaccharide (LPS-PG) and pentobarbital sodium were obtained from Invivogen (San Diego, CA) and Sigma (Shanghai, China), respectively. All other chemicals were of analytical grade and used as received.
Animals: New Zealand rabbits, 10 weeks old, weighing approximately 3.0 kg, were purchased from the Laboratory Animal Center of Sun Yat-sen University (Guangzhou, China). Studies were conducted in accordance with guidelines and procedures approved by the Institutional Authority for Laboratory Animal Care and Ethics Committee of Sun Yat-sen University.
Animals: New Zealand rabbits, 10 weeks old, weighing approximately 3.0 kg, were purchased from the Laboratory Animal Center of Sun Yat-sen University (Guangzhou, China). Studies were conducted in accordance with guidelines and procedures approved by the Institutional Authority for Laboratory Animal Care and Ethics Committee of Sun Yat-sen University.