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Emcompress

Manufactured by JRS Pharma
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Sourced in Germany

Emcompress® is a direct compression excipient used in the pharmaceutical industry. It is a form of microcrystalline cellulose that provides binding and disintegrating properties in solid dosage forms.

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Lab products found in correlation

Kollidon cl, by BASF (1 mentions) Pluronic f68, by Merck Group (1 mentions) Aerosil r972, by Evonik (1 mentions) Emcompress anhydrous, by JRS Pharma (1 mentions) Avicel ph102, by FMC Biopolymer (1 mentions) Ludipress, by BASF (1 mentions) Peg4000, by Merck Group (1 mentions) Kolliphor p188, by BASF (1 mentions)

4 protocols using emcompress

1

Superdisintegrants Influence on DCP Dissolution

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Sodium starch glycolate (SSG; Primojel, DFE Pharma, Goch, Germany) and crospovidone (XPVP; Kollidon CL, BASF, Ludwigshafen, Germany) were the superdisintegrants employed in this study. Dicalcium phosphate dihydrate (DCP; Emcompress, JRS Pharma, Rosenberg, Germany) was used as the filler. DCP was chosen as it is a commonly used diluent that does not exhibit aqueous solubility or strong wicking, which could be influenced by the disintegration medium temperature and confound the investigation. Magnesium stearate (M-125, Productos Metalest, Zaragoza, Spain) was used as the lubricant.
Zheng A.Y., Heng P.W, & Chan L.W. (2022). Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure. Pharmaceutics, 14(12), 2725.
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2

Formulation Development of Solid Dosage Forms

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Precirol® ATO 5 (Glycerol Distearate) and Compritol® 888 ATO (Glycerol Dibehenate) were obtained as gift samples from Gatefosse (St.Priest, France), Avicel® 102 (Micro-crystalline Cellulose) was obtained from FMC Biopolymer (Philadelphia, PA), Emcompress® (Dicalcium Phosphate Anhydrous, DCPA), from JRS Pharma (Rosenberg, Germany), Ludipress® (composed of Lactose monohydrate, Povidone K30 (Kollidon® 30) and Crospovidone (Kollidon® CL) from BASF Fine chemicals (Switzerland), Pluronic® F68 from Sigma Aldrich (St. Louis, Missouri), Aerosil® R972 from Evonik Industries (Germany), Magnesium Stearate (Mg. Stearate) from Spectrum Chemicals (Gardena, CA). All solvents used for analysis were of analytical grade.
Punyamurthula N.S., Hingorani T., Adelli G., Gul W., ElSohly M.A., Repka M.A, & Majumdar S. (2015). CONTROLLED RELEASE TABLET FORMULATION CONTAINING NATURAL Δ9 TETRAHYDROCANNABINOL. Drug development and industrial pharmacy, 42(7), 1158-1164.
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3

Formulation and Characterization of Oral Solid Dosage Forms

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Microcrystalline cellulose (MCC; Avicel PH102, FMC Biopolymer, Philadelphia, PA), lactose monohydrate (LM; #316 Fastflo® NF, Foremost Farms, Clayton, WI), mannitol (Mann; Pearlitol® 200SD, Roquette America Inc., Keokuk, IA), dicalcium phosphate anhydrate (DCPA; Anhydrous Emcompress®, JRS Pharma, Patterson, NY), dicalcium phosphate dihydrate (DCPD; Emcompress®, JRS Pharma, Patterson, NY), ibuprofen (IBN; Sigma Aldrich, St. Louis, MO), celecoxib (CEL; Aarti Drugs Pvt Ltd., Mumbai, India), hydroxypropyl cellulose (HPC; Klucel EF-PHARM, Ashland, Wilmington DE), and magnesium stearate (MgSt; non-bovine, HyQual™, Mallinckrodt, St. Louis, MO) were used as received.
Vreeman G, & Sun C.C. (2021). Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter. International Journal of Pharmaceutics: X, 3, 100094.
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4

Development of Co-Processed Excipients

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α-lactose monohydrate (LMH, Sigma Aldrich, St. Louis, MO, USA), polyethylene glycol 4000 (PEG 4000, Sigma Aldrich, St. Louis, MO, USA), poloxamer 188 (P188, Kolliphor® P188, BASF, Ludwigshafen, Germany), glyceryl palmitostearate (GPS, Precirol® ATO 5, Gattefossé, Saint-Priest, France), croscarmellose sodium (Primellose®, DFE Pharma, Goch, Germany), calcium dihydrogen phosphate dihydrate (Emcompress®, JRS Pharma, Rosenberg, Germany) have been used for the preparation of co-processed excipients. Commercially available co-processed excipient Ludipress® (BASF, Ludwigshafen, Germany) has been used for comparison with the prepared co-processed mixtures.
Medarević D., Djuriš J., Krkobabić M, & Ibrić S. (2021). Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing. Pharmaceutics, 13(12), 2165.
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