Gt(ROSA)26Sortm1(Notch1)Dam/J (Rosa26-NICD1) mice, B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J (Rosa26-EYFP) mice, B6.129S-Atoh1tm4.1Hzo/J (Math1M1GFP) mice, B6.Cg-Tg(Atoh1-cre)1Bfri/J (Math1-Cre) transgenic mice, and C57BL/6 mice (all from Jackson Laboratory, Bar Harbor, ME), and Tg(Lmx1a-cre)1Kjmi (Lmx1a-Cre) transgenic mice were maintained by breeding with C57BL/6 mice. Experimental procedures on animals housed at Sanford Research were approved by Sanford Research Institutional Animal Care and Use Committee and performed in compliance with national regulatory standards. No statistical method was used to predetermine sample size in animal experiments. The animal experiments were not randomized. The investigators were not blinded to group allocation during experiments and outcome assessment. Experimental animals were administered 100 mg/kg vismodegib (LC laboratories, Woburn, MA, V-4050) or vehicle following two regimens: daily treatment from day E15.5 through E18.5 (Mcre;NICD1 mice: 10 animals for each treatment); or from day E17.5 through day P7 (Lcre;NICD1 mice: 29 animals for vismodegib, 26 animals for vehicle), by gastric gavage of pregnant or nursing females.
Tg lmx1a cre 1kjmi
Manufactured by Jackson ImmunoResearch
Sourced in Montenegro
Tg(Lmx1a-cre)1Kjmi is a transgenic mouse line that expresses Cre recombinase under the control of the Lmx1a promoter. Lmx1a is a transcription factor involved in the development of specific neuronal populations. This mouse line can be used to target and manipulate gene expression in Lmx1a-expressing cells.
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2 protocols using tg lmx1a cre 1kjmi
1
Conditional Notch1 Activation in Mice
2
Conditional Notch1 Activation in Mice
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Gt(ROSA)26Sortm1(Notch1)Dam/J (Rosa26-NICD1) mice, B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J (Rosa26-EYFP) mice, B6.129S-Atoh1tm4.1Hzo/J (Math1M1GFP) mice, B6.Cg-Tg(Atoh1-cre)1Bfri/J (Math1-Cre) transgenic mice, and C57BL/6 mice (all from Jackson Laboratory, Bar Harbor, ME), and Tg(Lmx1a-cre)1Kjmi (Lmx1a-Cre) transgenic mice were maintained by breeding with C57BL/6 mice. Experimental procedures on animals housed at Sanford Research were approved by Sanford Research Institutional Animal Care and Use Committee and performed in compliance with national regulatory standards. No statistical method was used to predetermine sample size in animal experiments. The animal experiments were not randomized. The investigators were not blinded to group allocation during experiments and outcome assessment. Experimental animals were administered 100 mg/kg vismodegib (LC laboratories, Woburn, MA, V-4050) or vehicle following two regimens: daily treatment from day E15.5 through E18.5 (Mcre;NICD1 mice: 10 animals for each treatment); or from day E17.5 through day P7 (Lcre;NICD1 mice: 29 animals for vismodegib, 26 animals for vehicle), by gastric gavage of pregnant or nursing females.
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