Diverse small molecule compounds

Manufactured by AstraZeneca

Diverse small-molecule compounds are a collection of chemically diverse molecules that can be used in various laboratory applications. These compounds possess a range of physical and chemical properties, making them suitable for diverse research purposes.

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Lab products found in correlation

Microamp optical 384 well reaction plate, by Thermo Fisher Scientific (1 mentions)

2 protocols using diverse small molecule compounds

Diverse Small-Molecule Compound Library

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A library of 251,328 diverse small-molecule compounds (AstraZeneca) in 0.1% DMSO was arrayed in white 384-well microtiter plates at pre-established amounts or provided solubilized in DMSO at 10 mM. The compounds were selected as a representative subset of the entire corporate screening library to provide maximal chemical diversity, while retaining good physicochemical properties.

Brito H., Marques V., Afonso M.B., Brown D.G., Börjesson U., Selmi N., Smith D.M., Roberts I.O., Fitzek M., Aniceto N., Guedes R.C., Moreira R, & Rodrigues C.M. (2020). Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition. Cell Death Discovery, 6, 6.

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Screening of Diverse Small Molecule Library

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A library of 107 008 diverse small molecule compounds (AstraZeneca) in DMSO was arrayed, in pools of four compounds, in MicroAmp Optical 384-well reaction plates (Applied Biosystems, ThermoFisher Scientific). The compounds were selected as a representative subset of the entire corporate 2.2 million compound screening library to provide maximal chemical diversity, while retaining good physicochemical properties (see https://openinnovation.astrazeneca.com/target-innovation.html#).

Colomba A., Fitzek M., George R., Weitsman G., Roberts S., Zanetti-Domingues L., Hirsch M., Rolfe D.J., Mehmood S., Madin A., Claus J., Kjaer S., Snijders A.P., Ng T., Martin-Fernandez M., Smith D.M, & Parker P.J. (2020). A small molecule inhibitor of HER3: a proof-of-concept study. Biochemical Journal, 477(17), 3329-3347.

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