TRC105 was provided by TRACON Pharmaceuticals Inc. (San Diego, CA). PD-10 columns were purchased from GE Healthcare (Piscataway, NJ). IR Dye 800CW-NHS (NHS denotes N-hydroxysuccinimide) ester was acquired from LI-COR Biosciences Co. (Lincoln, NE). SCM-PEG5k-Mal was obtained from Creative PEGworks. NOTA-SCN (i.e., 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid) was acquired from Macrocyclics, Inc. (Dallas, TX). NHS-fluorescein, Chelex 100 resin (50–100 mesh), tetraethyl orthosilicate (TEOS), ammonia (NH3·H2O), triethylamine (TEA), 3-aminopropyl)triethoxysilane (APS), dimethyl sulfoxide, cetyltrimethylammonium chloride (CTAC, 25 wt %), and Kaiser test kit were purchased from Sigma-Aldrich (St. Louis, MO). Traut’s reagent (2-Iminothiolane·HCl) and Ellman’s reagent (5,5′-dithiobis(2-nitrobenzoic acid) or DTNB) were purchased from Fisher Scientific. Water and all buffers were of Millipore grade and pretreated with Chelex 100 resin to ensure that the aqueous solution was free of heavy metals. All chemicals were used as received without further purification.
Nota scn
Manufactured by Macrocyclics
NOTA-SCN is a bifunctional chelating agent that can be used for the conjugation of radioisotopes to biological molecules such as antibodies, peptides, and proteins. It contains a NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) chelator and an activated N-succinimidyl ester (SCN) group for covalent attachment to primary amines.
Automatically generated - may contain errors
Lab products found in correlation
Traut s reagent 2 iminothiolane hcl, by Thermo Fisher Scientific (2 mentions)
Scm peg5k mal, by Creative PEGWorks (2 mentions)
Irdye800cw nhs, by LI COR (2 mentions)
Nhs fluorescein, by Merck Group (2 mentions)
Pd 10 column, by GE Healthcare (2 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (2 mentions)
Kaiser test kit, by Merck Group (2 mentions)
3 aminopropyl triethoxysilane aps, by Merck Group (1 mentions)
Chelex 100 resin, by Merck Group (1 mentions)
2 protocols using nota scn
1
Bioconjugation of TRC105 with IR Dye 800CW
2
Bioconjugation of TRC105 with IR Dye
Check if the same lab product or an alternative is used in the 5 most similar protocols
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TRC105 was provided by TRACON Pharmaceuticals
Inc. (San Diego, CA). PD-10 columns were purchased from GE Healthcare
(Piscataway, NJ). IR Dye 800CW-NHS (NHS denotes N-hydroxysuccinimide) ester was acquired from LI-COR Biosciences Co.
(Lincoln, NE). SCM-PEG5k-Mal was obtained from Creative
PEGworks. NOTA-SCN (i.e., 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic
acid) was acquired from Macrocyclics, Inc. (Dallas, TX). NHS-fluorescein,
Chelex 100 resin (50–100 mesh), tetraethyl orthosilicate (TEOS),
ammonia (NH3·H2O), triethylamine (TEA),
3-aminopropyl)triethoxysilane (APS), dimethyl sulfoxide, cetyltrimethylammonium
chloride (CTAC, 25 wt %), and Kaiser test kit were purchased from
Sigma-Aldrich (St. Louis, MO). Traut’s reagent (2-Iminothiolane·HCl)
and Ellman’s reagent (5,5′-dithiobis(2-nitrobenzoic
acid) or DTNB) were purchased from Fisher Scientific. Water and all
buffers were of Millipore grade and pretreated with Chelex 100 resin
to ensure that the aqueous solution was free of heavy metals. All
chemicals were used as received without further purification.
Inc. (San Diego, CA). PD-10 columns were purchased from GE Healthcare
(Piscataway, NJ). IR Dye 800CW-NHS (NHS denotes N-hydroxysuccinimide) ester was acquired from LI-COR Biosciences Co.
(Lincoln, NE). SCM-PEG5k-Mal was obtained from Creative
PEGworks. NOTA-SCN (i.e., 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic
acid) was acquired from Macrocyclics, Inc. (Dallas, TX). NHS-fluorescein,
Chelex 100 resin (50–100 mesh), tetraethyl orthosilicate (TEOS),
ammonia (NH3·H2O), triethylamine (TEA),
3-aminopropyl)triethoxysilane (APS), dimethyl sulfoxide, cetyltrimethylammonium
chloride (CTAC, 25 wt %), and Kaiser test kit were purchased from
Sigma-Aldrich (St. Louis, MO). Traut’s reagent (2-Iminothiolane·HCl)
and Ellman’s reagent (5,5′-dithiobis(2-nitrobenzoic
acid) or DTNB) were purchased from Fisher Scientific. Water and all
buffers were of Millipore grade and pretreated with Chelex 100 resin
to ensure that the aqueous solution was free of heavy metals. All
chemicals were used as received without further purification.
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