PiB was synthesized by a simplified radiosynthetic method based on the captive solvent method.43 (link) Prior to acquisition, 15 mCi of high specific activity (~2.1 Ci/μmol at EOS) [11C]PiB was injected intravenously over 20 seconds. A 10–15 minutes windowed transmission scan was acquired for attenuation correction, followed by a 20-minute emission scan (4 × 300 second frames) beginning 50 minutes postinjection. Data were acquired on a Siemens/CTI ECAT HR + scanner (Siemens Medical Solutions, Knoxville, TN) in 3D mode (63 axial imaging planes, FOV 15.2 cm, inplane resolution 4.1 mm full-width at half-maximum at FOV center, axial slice width 2.4 mm). Scanner is equipped with a neuro-insert to reduce scattered photon contribution. PET emission data were reconstructed using filtered back projection correcting for attenuation, scatter, and radionuclide decay.
Cti ecat hr scanner
Manufactured by Siemens
The Siemens/CTI ECAT HR+ scanner is a positron emission tomography (PET) system designed for high-resolution imaging. It provides advanced capabilities for various clinical and research applications.
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8 protocols using cti ecat hr scanner
1
PET Imaging of Amyloid-Beta with [11C]PiB
2
Radiosynthesis and PET Imaging of [11C]PiB
3
Simplified [11C]PiB Radiosynthesis and PET Imaging
4
In Vivo Quantification of Amyloid-Beta Using [11C]PiB PET
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[11C]Pittsburgh compound‐B ([11C]PiB) was synthesized in accordance with previously described methods.
28 (link) PET imaging was performed as described previously.
21 (link) Briefly, PET imaging was performed using a Siemens/CTI ECAT HR+ scanner (Siemens Medical Solutions, Knoxville, TN) operating in three‐dimensional (3D) imaging mode. Subjects were injected intravenously with 15 mCi of high specific activity [11C]PiB (> 2 Ci/μmol at end‐of‐synthesis) before being positioned in the scanner. Following a 10–15 min transmission scan using rotating 68Ge/68Ga rod sources for the purpose of attenuation correction of PET emission data, a 20‐min emission scan was acquired (4 × 5 min frames) beginning 50 min after injection. PET emission data were reconstructed using 3D filtered back projection with Fourier rebinning, and standard corrections for photon attenuation, scatter, and radioactive decay were applied.
28 (link) PET imaging was performed as described previously.
21 (link) Briefly, PET imaging was performed using a Siemens/CTI ECAT HR+ scanner (Siemens Medical Solutions, Knoxville, TN) operating in three‐dimensional (3D) imaging mode. Subjects were injected intravenously with 15 mCi of high specific activity [11C]PiB (> 2 Ci/μmol at end‐of‐synthesis) before being positioned in the scanner. Following a 10–15 min transmission scan using rotating 68Ge/68Ga rod sources for the purpose of attenuation correction of PET emission data, a 20‐min emission scan was acquired (4 × 5 min frames) beginning 50 min after injection. PET emission data were reconstructed using 3D filtered back projection with Fourier rebinning, and standard corrections for photon attenuation, scatter, and radioactive decay were applied.
5
Simplified [11C]PiB Radiosynthesis and PET Imaging
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As detailed in Wilson et al. (48 (link)), [11C]PiB was synthesized by a simplified radiosynthetic method based on the captive solvent method. Fifteen 15 mCi of high-specific activity [11C]PiB (~2.1 Ci/μmol at end-of-synthesis) was injected intravenously over 20 s prior to scan acquisition. In order to correct for attenuation, a 10–15 min windowed transmission scan was acquired, followed by a 20-min emission scan (4 × 300 s frames) beginning 50-min post-injection.
These scans were acquired on a Siemens/CTI ECAT HR+ scanner (Siemens Medical Solutions, Knoxville, TN) in 3D mode [63 axial imaging planes, field-of-view (FOV) 15.2 cm, in-plane resolution 4.1 mm full-width at half-maximum, at FOV center, axial slice width 2.4 mm], which is equipped with a neuro-insert to reduce scattered photon contribution. PET emission data were reconstructed using filtered back projection and included standard corrections for attenuation, scatter, and radionuclide decay. Of note, four memory clinic participants were missing [11C]PiB-PET data, and these participants were excluded only from the analyses that included Aβ load.
These scans were acquired on a Siemens/CTI ECAT HR+ scanner (Siemens Medical Solutions, Knoxville, TN) in 3D mode [63 axial imaging planes, field-of-view (FOV) 15.2 cm, in-plane resolution 4.1 mm full-width at half-maximum, at FOV center, axial slice width 2.4 mm], which is equipped with a neuro-insert to reduce scattered photon contribution. PET emission data were reconstructed using filtered back projection and included standard corrections for attenuation, scatter, and radionuclide decay. Of note, four memory clinic participants were missing [11C]PiB-PET data, and these participants were excluded only from the analyses that included Aβ load.
6
Multimodal PET Imaging of Cerebral Hemodynamics
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The PET data were acquired on a CTI ECAT HR+ scanner (Siemens, Knoxville, TN). A thermoplastic facial mask was used to minimize head motion during scans. The 15O-labeled tracers were produced by an onsite cyclotron (MC-17, Scanditronix Magnet AB, Sweden).
Before the PET scans, an catheter was placed in a radial artery; an antecubital venous catheter was placed in the contralateral forearm. A transmission scan was performed for attenuation correction.
Subsequently, two sessions of 15O PET scans were performed to sequentially quantify PET-based BV, BF and MRO2, with different radiotracers (C15O, H215O, and 15O2). Acquisition parameters details for 15O PET have been described in (Jiang et al., 2021 (link)).
For the 18FDG scans, after bolus intravenous administration of 5mCi±10% FDG, 70 frames of 3D dynamic emission scans were acquired over 70 min (70 frames x 1 min). Sixteen arterial blood samples (about 1.5 mL each) were collected to calculate the arterial input function (6 × 30s, 10 × 10min). After centrifuge, blood serum was extracted to determine the arterial input function.
During scans and arterial blood sample acquisition, subjects laid quietly in a dark room with their eyes closed. PET reconstruction was by filtered back-projection using a 3 mm smoothing kernel, resulting in a voxel size of 2.0 × 2.0 × 2.4 (slice) mm3.
Before the PET scans, an catheter was placed in a radial artery; an antecubital venous catheter was placed in the contralateral forearm. A transmission scan was performed for attenuation correction.
Subsequently, two sessions of 15O PET scans were performed to sequentially quantify PET-based BV, BF and MRO2, with different radiotracers (C15O, H215O, and 15O2). Acquisition parameters details for 15O PET have been described in (Jiang et al., 2021 (link)).
For the 18FDG scans, after bolus intravenous administration of 5mCi±10% FDG, 70 frames of 3D dynamic emission scans were acquired over 70 min (70 frames x 1 min). Sixteen arterial blood samples (about 1.5 mL each) were collected to calculate the arterial input function (6 × 30s, 10 × 10min). After centrifuge, blood serum was extracted to determine the arterial input function.
During scans and arterial blood sample acquisition, subjects laid quietly in a dark room with their eyes closed. PET reconstruction was by filtered back-projection using a 3 mm smoothing kernel, resulting in a voxel size of 2.0 × 2.0 × 2.4 (slice) mm3.
7
Multimodal PET Imaging of Cerebral Hemodynamics
8
PiB-PET and MRI-Guided Amyloid Imaging
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All subjects underwent [C-11]PiB PET and MR imaging prior to death (see Table 1 for imaging details). Subjects received a spoiled gradient recalled MR scan (1.5 T, GE Signa) (n = 8) or a magnetization prepared rapid gradient echo MR scan (3 T, Siemens Tim Trio) (n = 1) for anatomic VOI definition and PVC tissue segmentation guidance. PET data were acquired as previously described (Price et al., 2005 (link); Lopresti et al., 2005 (link)) using a Siemens/CTI ECAT HR+ scanner (3-dimensional mode, 63 image planes, 15.2 cm field of view) following slow bolus injection of 14.9 ± 1.7 kBq of high specific activity (>21.4 GBq/μmol) [C-11]PiB. PET emission data were acquired over 0–90 min (34 frames, n = 7) or 40–70 min (6 frames, n = 2) post injection. PET data were corrected for attenuation, scatter, and radioactivity decay, and reconstructed using the Direct Fourier (DIFT) method, similar to filtered backprojection, with a 3 mm Hann filter into a 128 × 128 × 63 matrix with voxel sizes of 2.06 × 2.06 × 2.43 mm3. The reconstructed PET image resolution was approximately 6 mm FWHM in the transverse and axial planes, measured using a point source phantom imaged in the center of the PET scanner field of view (FOV).
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