Ecat high resolution research tomograph hrrt

Manufactured by Siemens

Sourced in United States

The ECAT High Resolution Research Tomograph (HRRT) is a positron emission tomography (PET) scanner designed for high-resolution brain imaging. The HRRT offers exceptional spatial resolution and high sensitivity, making it a valuable tool for advanced neuroscience research.

Automatically generated - may contain errors

Lab products found in correlation

Ingenia 3.0t, by Philips (2 mentions) Advance tomograph, by GE Healthcare (1 mentions)

Close spelling variants of this product

High Resolution Research Tomograph ECAT HRRT

6 protocols using ecat high resolution research tomograph hrrt

Multimodal Brain Imaging in Neurodegenerative Disorders

Check if the same lab product or an alternative is used in the 5 most similar protocols

Structural T1-weighted brain MRI scan was performed on either a Philips Ingenuity 3.0 T TF PET/MRI (n = 38; Philips Healthcare, Amsterdam, the Netherlands) or a Philips Ingenia 3.0 T (n = 22; Philips Healthcare, Amsterdam, the Netherlands). PET scans were acquired on an ECAT high-resolution research tomograph (HRRT, Siemens Medical Solutions, Knoxville, TN). For amyloid imaging, ¹¹C-PiB scans (n = 60) were acquired 40 to 90 min post injection (mean injected dose 497 (standard deviation (SD) 30) MBq), and for TSPO imaging, dynamic ¹¹C-PK11195 scans (n = 57) were acquired for 60 min post injection (mean injected dose 494 (SD 21) MBq). All images were reconstructed with 3D ordinary Poisson ordered subset expectation maximization algorithm (OP-OSEM3D), and list mode data was histogrammed into 8 (6 × 5 + 2 × 10 min, ¹¹C-PiB) and 17 (2 × 15; 3 × 30; 3 × 60; 7 × 300; 2 × 600 s, ¹¹C-PK11195) time frames.

Snellman A., Ekblad L.L., Tuisku J., Koivumäki M., Ashton N.J., Lantero-Rodriguez J., Karikari T.K., Helin S., Bucci M., Löyttyniemi E., Parkkola R., Karrasch M., Schöll M., Zetterberg H., Blennow K, & Rinne J.O. (2023). APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly. Alzheimer's Research & Therapy, 15, 71.

+ Open protocol

+ Expand

Multimodal Neuroimaging of Alzheimer's Biomarkers

Check if the same lab product or an alternative is used in the 5 most similar protocols

All subjects underwent a structural brain MRI including T1-weighted and T2-FLAIR sequences. Structural brain images were acquired by two different scanners, either with Philips Ingenuity 3.0 T TF PET/MRI (n = 38; Philips Healthcare, Amsterdam, the Netherlands) or Philips Ingenia 3.0 T (n = 22; Philips Healthcare, Amsterdam, the Netherlands).
MRI was used to acquire volumetric variables (hippocampal volume, parahippocampal volume and entorhinal volume), global cortical atrophy score, medial temporal lobe atrophy score, and total volume of white matter hyperintensities. To determine brain Aβ load, [¹¹C]PiB PET scans (n = 60) were acquired from 40 to 90 min post injection (mean injected dose 497 [30 ] MBq) with an ECAT high-resolution research tomograph (HRRT, Siemens Medical Solutions, Knoxville, TN).

Koivumäki M., Ekblad L., Lantero-Rodriguez J., Ashton N.J., Karikari T.K., Helin S., Parkkola R., Lötjönen J., Zetterberg H., Blennow K., Rinne J.O, & Snellman A. (2024). Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly. Alzheimer's Research & Therapy, 16, 112.

+ Open protocol

+ Expand

Quantifying Amyloid-Beta Deposition with FBP-PET

Check if the same lab product or an alternative is used in the 5 most similar protocols

Participants received ¹⁸F‐florbetapir‐PET (FBP) to quantify Aβ on an ECAT High Resolution Research Tomograph (HRRT, CTI/Siemens, Knoxville, TN, USA); 10 mCi of tracer was injected, and four, 5‐min frames were collected from 50 to 70 min post‐injection. Data were reconstructed with attenuation correction, scatter correction, and 2 mm³ Gaussian smoothing. Data were realigned, coregistered to the structural MRI, and normalized by a whole cerebellum reference region to produce standardized uptake value ratio (SUVR) images. Additional smoothing was applied to achieve an effective resolution of 8 mm³. The mean SUVR of a previously validated cortical composite region was quantified (FBP SUVR) and used to determine Aβ‐PET positivity using a threshold of > 1.11 SUVR.²⁶, ²⁷

Adams J.N., Márquez F., Larson M.S., Janecek J.T., Miranda B.A., Noche J.A., Taylor L., Hollearn M.K., McMillan L., Keator D.B., Head E., Rissman R.A, & Yassa M.A. (2023). Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 15(2), e12419.

+ Open protocol

+ Expand

Amyloid PET Imaging Protocol

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

Participants received 18F-florbetapir PET (FBP) at the CCNI with an ECAT High Resolution Research Tomograph (HRRT, CTI/Siemens, Knoxville, TN, USA). Ten mCi of tracer was injected, and four five-minute frames were collected between 50 and 70 min post-injection. FBP data was reconstructed with attenuation correction, scatter correction, and 2 mm³ Gaussian smoothing. Frames were realigned, averaged, coregistered to the T1 MRI, and normalized by a whole cerebellum reference region to compute SUVR images. Additional 6 mm³ smoothing was then applied to achieve an effective resolution of 8 mm³. We calculated a global measure of FBP SUVR across a previously validated cortical composite region^{32 (link)}. Aβ+ status was determined using a threshold of > 1.11 global FBP SUVR^{32 (link)}.

Adams J.N., Chappel-Farley M.G., Yaros J.L., Taylor L., Harris A.L., Mikhail A., McMillan L., Keator D.B, & Yassa M.A. (2023). Functional network structure supports resilience to memory deficits in cognitively normal older adults with amyloid-β pathology. Scientific Reports, 13, 13953.

+ Open protocol

+ Expand

Multimodal PET Imaging of Neurotransmitter Systems

Check if the same lab product or an alternative is used in the 5 most similar protocols

Imaging was carried out using ¹⁸F-6-fluoro-L-dopa (FDOPA, a measure of dopamine synthesis and storage), (+)-¹¹C-dihydrotetrabenazine (DTBZ, marker for the vesicular monoamine transporter type 2), and ¹¹C-raclopride (RAC, marker of dopamine D2/D3 receptors), and ¹¹C-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB, marker of the serotonin transporter). Imaging with dopaminergic tracers was performed on the GE Advance tomograph (4.2 mm resolution FWHM), while DASB scanning took place on the Siemens ECAT high resolution research tomograph (HRRT, 2.3 mm resolution FWHM). Emission data were collected for 60 (DTBZ, RAC), 90 (FDOPA), or 100 minutes (DASB) following bolus injection of the PET tracer. This study was approved by the University of British Columbia Ethics Committee.

Felicio A.C., Dinelle K., Agarwal P.A., McKenzie J., Heffernan N., Road J.D., Appel-Cresswell S., Wszolek Z.K., Farrer M.J., Schulzer M., Sossi V, & Stoessl A.J. (2014). In vivo dopaminergic and serotonergic dysfunction in DCTN1 gene mutation carriers. Movement disorders : official journal of the Movement Disorder Society, 29(9), 1197-1201.

+ Open protocol

+ Expand

PET Imaging of Yohimbine Binding in Parkinson's

Check if the same lab product or an alternative is used in the 5 most similar protocols

Before the PET imaging, subjects paused L-DOPA medication for at least 12 h and paused direct dopamine agonists for more than 24 h. We evaluated the severity of motor symptoms with the Unified Parkinson’s Disease Rating Scale (UPDRS) Part 3 in the “off” state. We used the PET imaging protocol for [¹¹C]yohimbine, described and validated in a previous study from this group [11 (link)]. All participants reclined in the ECAT High Resolution Research Tomograph (HRRT, CTI/Siemens, Knoxville, TN, USA), with their heads immobilized by a custom-built head-holder. We obtained 6 min transmission scans and 90 min dynamic PET scans, consisting of 28 frames with increasing duration (8 × 15 s, 4 × 30 s, 6 × 60 s, 4 × 300 s, 6 × 600 s), the latter recorded in list mode upon administration of a bolus [¹¹C]yohimbine.

Kemp A.F., Kinnerup M., Johnsen B., Jakobsen S., Nahimi A, & Gjedde A. (2024). EEG Frequency Correlates with α2-Receptor Density in Parkinson’s Disease. Biomolecules, 14(2), 209.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!