B6cr 129s4 tnfsf4tm1sug pgn

BALB/cJ, C.129-Il4^tm1Lky/J (4get), C57BL/6J, B6.129P2-Tcrb^tm1Mom/J (Tcrb^−/−), STOCK Tg(Cd4-cre)1Cwi/BfluJ (CD4-Cre), B6.129S7-Il7r^tm1Imx/J (Il7r^−/−), B6Cr.129S4-Tnfsf4^tm1Sug/Pgn (Tnfsf4^−/−), B6.129P2-Icos^tm1Mak/J (Icos^−/−), and B6.129S7-Il1r1^tm1lmx/J (Il1r1^−/−) mice were obtained from Jackson Laboratories (Bar Harbor, ME). The Bcl6^fl/fl mice were previously described.^{14 (link)} The procedures and handling of the mice were reviewed and approved by the Mayo Institutional Animal Care and Use Committee, Mayo Clinic, Rochester, MN.

BALB/c, C57BL/6, C.C3-Tlr4^Lps-d/J (Tlr4^-d), C.129-Il4^tm1Lky/J (4get), Tg(Cd4-cre)1Cwi/BfluJ (Cd4-Cre), B6.129P2-Tcrb^tm1Mom/J (Tcrb^−/−), B6Cr.129S4-Tnfsf4^tm1Sug/Pgn (Tnfsf4^−/−), B6;129S1-Il1rap^tm1Roml/J (Il1rap^−/−), and B6.129S7-Il1r1^tm1Imx/J (Il1r^−/−) mice were obtained from The Jackson Laboratory (Bar Harbor, ME, USA). Il1rap^−/− mice were subsequently backcrossed onto the BALB/c background for 10 generations. Il1rl1^−/− (ST2^−/−) mice and Crlf2^−/− (Tslpr^−/−) mice (both BALB/c background) were kindly provided by Dr. Andrew McKenzie (MRC Laboratory of Molecular Biology, Cambridge, UK) and Dr. Steven F. Ziegler (Benaroya Research Institute, Seattle, WA, USA), respectively, and were bred under specific pathogen-free (SPF) conditions at the Mayo Clinic (Rochester, MN, USA)^{21 (link), 22 (link)}. Bcl6^fl/fl mice were previously described^{23 (link)}. Animals used in this study were female and ranged from 6–12 weeks of age. All protocols and procedures for handling of the mice were reviewed and approved by the Mayo Institutional Animal Care and Use Committee, Mayo Clinic.