Magnetom aera 1.5t system

Seios Intracranianos ► Biomarcadores ► Inflamação using cranial magnetic resonance imaging (MRI) and contrast-enhanced magnetic resonance venography (MRV) at Bezmialem Foundation University's Faculty of Medicine Hospital from January 2014 to January 2022. A total of 40 age-and sex-matched patients who presented with a diagnosis of primary headache and were admitted to the neurology outpatient clinic were included in the sample as the control group. The study was approved by the Clinical Research Ethics Committee of the university (approval number: E-54022451-050.05.04-104344; date: April 5, 2023) and conducted in accordance with the principles of the Declaration of Helsinki.
All cranial MRI and MRV scans were performed on the Magnetom Aera 1.5T system (Siemens Healthineers, Erlangen, Germany) using a 24-channel head coil. The analyzed sequences consisted of 5-mm sections. Patients without MRI and MRV scans at the time of the diagnosis were not included in the study. The other exclusion criteria were defined as follows: arterial stroke, acute myocardial infarction, infection, autoimmune diseases, hematological disorders, liver failure, peripheral vascular diseases, any inflammatory conditions, malignancy, use of anti-inflammatory, antiplatelet, anticoagulant, or lipid-regulating medications, incomplete clinical data, and insufficient imaging data.

All MRI were performed on the Magnetom Aera 1.5T system (Siemens Healthcare, Erlangen, Germany). Brain MRIs were performed with a 24-channel head coil. The sequences analysed consisted of 5-mm sections, and T2W axial images were used for measurements. The left and right ETD (i.e., retina to retina), OTD (i.e., medial orbital wall to lateral orbital wall), and ONSDs were measured by the computer programme on the same MRI (Fig. 1). The measurements were made digitally via PACS. Theoretical and practical orbital anatomy and measurement technique training on MRI were given to the researchers who made the measurements. MRI of patients in the control group and the PTC group were randomly mixed, so the measurements were blinded. The parts of interest of the MRI were enlarged 3-4 times for better measurement. ONSD and OTD measurements were made from 3 mm and 10 mm behind the globe (Fig. 1). The researchers took care to use the same window, brightness, and contrast when taking all measurements. Intra-evaluator and inter-evaluator consistency were analysed statistically by the intraclass correlation coefficients (ICCs) between the two evaluators. The same methodological procedures were applied by both evaluators (A.B. and T.E.) when making measurements. ICP was measured invasively in a neurosurgical intensive care unit with lumbar puncture (LP).